Gluten-free diet and reintroduction of gluten in dermatitis herpetiformis

Failure of Added Dietary Gluten to Induce Small Intestinal Histopathological Changes in Patients with Watery Diarrhea and Lymphocytic Colitis

“…Small bowel biopsy changes were also described in patients challenged with 10 g of gluten/day for an average of 11.9 weeks to demonstrate the gluten-dependent nature of the skin rash in dermatitis herpetiformis (25). These findings confirmed earlier observations (26). In another report (27), asymptomatic relatives of patients with celiac disease showed small intestinal crypt lengthening after their normal diet was supplemented with 40 g of gluten/day for six weeks.…”

The small intestine in dermatitis herpetiformis

“…The enteropathy in these patients is similar to that found in adult coeliac disease since it responds to a glutenfree diet (Fry, McMinn, Cowan, Hoffbrand, 1968Shuster, Watson, and Marks, 1968;Marks and Whittle, 1969), and relapses on the re-introduction of gluten (Fry et al, 1969). Recently, Gebhard, Katz, the characteristic response of the rash to dapsone are not in themselves diagnostic.…”

“…This suggestion is supported by the finding of a low incidence of clinical and laboratory evidence of malabsorption (Fry et al, 1967;Shuster et al, 1968;Marks and Whittle, 1969). It is now well established, however, that the enteropathy, although mild, is due to gluten sensitivity (Fry et al, 1968(Fry et al, , 1969Shuster et al, 1968;Weinstein, Brow, Parker, and Rubin, 1971).…”

Persistent Skin Symptoms after Diagnosis and on a Long-term Gluten-free Diet in Dermatitis Herpetiformis

“…The earlier diagnostic period was linked to the prolongation of cutaneous symptoms in DH in this study. During the earliest diagnostic period (1970–1984), even though the awareness of GFD as the main treatment for DH was increasing ( 5 , 6 , 34 ), the importance of strict adherence to a GFD was less obvious and, furthermore, the availability and selection of gluten-free products was not as good as during the later years. Thus, poorer adherence to a GFD after diagnosis might explain at least partly the prolongation of skin symptoms among those diagnosed during the earlier diagnostic period in the current study.…”