2006
DOI: 10.1517/13543776.16.4.431
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GlutathioneS-transferase (GST) inhibitors

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Cited by 35 publications
(26 citation statements)
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“…c, 36, 52 However, the peptidic character of the GSH derivatives limits their application in vivo, as they are sensitive to biological degradation by peptidases, such as γ‐glutamyl transpeptidase 52b. 53…”
Section: Resultsmentioning
confidence: 99%
“…c, 36, 52 However, the peptidic character of the GSH derivatives limits their application in vivo, as they are sensitive to biological degradation by peptidases, such as γ‐glutamyl transpeptidase 52b. 53…”
Section: Resultsmentioning
confidence: 99%
“…Glutathione‐ S ‐transferases (GSTs) are a family of dimeric multifunctional enzymes that play an important role in metabolism and detoxification of numerous xenobiotics, electrophilic chemicals (including drugs), environmental carcinogens, and products of oxidative stress in living organisms 1. Aside from their detoxifying reaction (typically a conjugation reaction), GSTs catalyze many other types of reaction, such as isomerization and reduction involved in many biological processes, e.g., steroid and prostaglandin biosynthesis, tyrosine catabolism, and cell apoptosis 2…”
Section: Introductionmentioning
confidence: 99%
“…GSTs are a family of phase II detoxification enzymes that catalyze the conjugation of GSH to a wide variety of electrophilic compounds. GSTs catalyze the conjugation of the reduced form of glutathione (GSH) to electrophilic centers of endogenous and exogenous hydrophobic compounds 1. For GST‐mediated catalytic reactions, the activation of the sulfur atom of the G‐site‐bound glutathione (GSH) to the thiolate anion (GS − , a strong nucleophile) is required to generate a GS–substrate conjugate by attack of the electrophilic center of substrates bound to the H‐site.…”
Section: Introductionmentioning
confidence: 99%
“…The GST superfamily is composed of at least 6 classes of isozymes: Alpha (α or A), Mu (μ, or M), Pi (π, or P), Omega (ω, or O), Theta (θ, or T), and Zeta (ζ, or Z)8, 9. In recent years, specific GST isoforms have been implicated in the clearance of drugs and environmental toxicants, such as carcinogens and pesticides, as well as in the metabolism of endogenously produced compounds such as lipid peroxidation by-products916. A number of polymorphisms in the genes encoding GSTs have been described and associated with altered enzyme expression and/or activity6, 7.…”
Section: Introductionmentioning
confidence: 99%