Glutathione antioxidant system as a marker of oxidative stress in chronic renal failure

Ceballos-Picot, Irène; Witko‐Sarsat, Véronique; Merad-Boudia, Mansouria; Nguyen, Anh Thu; Thévenin, M.; Jaudon, M C; Zingraff, J.; Verger, Christian; Jingers, Paul; Descamps‐Latscha, Béatrice

doi:10.1016/0891-5849(96)00233-x

Cited by 343 publications

(267 citation statements)

References 41 publications

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“…In human patients with kidney disease, plasma selenium concentrations decrease as the disease progresses 3, 10, 20. The decrease in selenium concentrations is ascribed to low protein intake and increased protein loss attributable to proteinuria, which develops over the course of the disease 30.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported decreased activity of plasma GPx in human chronic kidney disease patients, regardless of the stage of the disease 3, 11, 13, 14. Decreased GPx activity may be because of an increased rate of lipid peroxidation, a decrease in functional renal mass,3, 14, 20 the interference of uremic toxins,14, 20 plasma GPx consumption and inactivation by biochemical modification, or an abnormality in the hexose monophosphate pathway 20.…”

Section: Discussionmentioning

confidence: 99%

“…It is characterized by progressive loss of kidney function, which results in renal fibrosis, uremia, and death 2. In human uremic patients, a state of imbalance between pro‐oxidative and antioxidative processes has been established, and defined as oxidative stress with increased amounts of reactive oxygen species (ROS) present 3, 4, 5. ROS are involved in cell signaling and cause activation of proinflammatory and mitogenic cellular pathways, which enhance the progression of renal fibrosis and cause a progressive decline in renal function 5, 6, 7.…”

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confidence: 99%

“…The activity of GPx is decreased in human CKD patients. Plasma GPx activity therefore is an important diagnostic and prognostic factor of CKD in humans 3, 10, 11…”

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confidence: 99%

“…Some studies report that erythrocyte GPx activity is significantly increased early in the development of CKD, but remains stable until progression to end‐stage kidney disease 3. Other studies showed no significant differences in erythrocyte GPx activities between CKD patients and healthy controls 10, 13.…”

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confidence: 99%

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Plasma and Erythrocyte Glutathione Peroxidase Activity, Serum Selenium Concentration, and Plasma Total Antioxidant Capacity in Cats with IRIS Stages I–IV Chronic Kidney Disease

Žel

Tozon

Svete

2013

Veterinary Internal Medicne

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BackgroundSerum selenium concentrations and the activity of plasma glutathione peroxidase (GPx) decrease with the progression of chronic kidney disease (CKD) in human patients. Selenium is considered a limiting factor for plasma GPx synthesis. Plasma total antioxidant capacity (TAC) is decreased in CKD cats in comparison to healthy cats.HypothesisSerum selenium concentrations and plasma and erythrocyte GPx activity in cats with CKD are lower than in healthy cats. Serum selenium concentrations, the activity of enzymes, and plasma TAC progressively decrease with the progression of kidney disease according to IRIS (International Renal Interest Society) classification.AnimalsTwenty‐six client‐owned cats in IRIS stages I–IV of CKD were compared with 19 client‐owned healthy cats.MethodsA CBC, serum biochemical profile, urinalysis, plasma and erythrocyte GPx activity, serum selenium concentration, and plasma TAC were measured in each cat.ResultsCats in IRIS stage IV CKD had a significantly higher (P = .025) activity of plasma GPx (23.44 ± 6.28 U/mL) than cats in the control group (17.51 ± 3.75 U/mL). There were no significant differences in erythrocyte GPx, serum selenium concentration, and plasma TAC, either among IRIS stages I–IV CKD cats or between CKD cats and healthy cats.Conclusions and Clinical ImportanceErythrocyte GPx activity, serum selenium concentration, and plasma TAC do not change in CKD cats compared with healthy cats. Selenium is not a limiting factor in feline CKD. Increased plasma GPx activity in cats with stage IV CKD suggests induction of antioxidant defense mechanisms. Antioxidant defense systems might not be exhausted in CKD in cats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

“…The activity of GPx is decreased in human CKD patients. Plasma GPx activity therefore is an important diagnostic and prognostic factor of CKD in humans 3, 10, 11…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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Plasma and Erythrocyte Glutathione Peroxidase Activity, Serum Selenium Concentration, and Plasma Total Antioxidant Capacity in Cats with IRIS Stages I–IV Chronic Kidney Disease

Žel

Tozon

Svete

2013

Veterinary Internal Medicne

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Proteome Analysis of Oxidative Stress: Glutathionyl Hemoglobin in Diabetic and Uremic Patients

Niwa

2006

Redox Proteomics

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Ligand reaction‐based fluorescent peptide probes for the detection of Cu²⁺ and glutathione

Zhou,

Hao,

Wang

et al. 2024

Luminescence

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Copper is a critical element in both human and animal metabolic processes. Its role includes supporting connective tissue cross‐linking, as well as iron and lipid metabolism; at the same time, copper is also a toxic heavy metal that can cause harm to both the environment and human health. Glutathione (GSH) is a tripeptide composed of glutamic acid, cysteine, and glycine combined with sulfhydryl groups. Its properties include acting as an antioxidant and facilitating integrative detoxification. GSH is present in both plant and animal cells and has a fundamental role in maintaining living organisms. GSH is the most abundant thiol antioxidant in the human body. It exists in reduced and oxidized forms within cells and provides significant biochemical functions, such as regulating vitamins such as vitamins D, E, and C, and facilitating detoxification. A fluorescent probe has been developed to detect copper ions selectively, sensitively, and rapidly. This report outlines the successful work on creating a peptide probe, TGN (TPE‐Trp‐Pro‐Gly‐Cln‐His‐NH2), with specific Cu2+ detection capabilities, and a significant fluorescence recovery occurred with the addition of GSH. This indicates that the probe can detect Cu2+ and GSH concurrently. The detection limit for Cu2+ in the buffer solution was 264 nM (R2 = 0.9992), and the detection limit for GSH using the TGN‐Cu2+ complex was 919 nM (R2 = 0.9917). The probe exhibits high cell permeability and low biotoxicity that make it ideal for live cell imaging in biological conditions. This peptide probe has the capability to detect Cu2+ and GSH in biological cells.

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Glutathione antioxidant system as a marker of oxidative stress in chronic renal failure

Cited by 343 publications

References 41 publications

Plasma and Erythrocyte Glutathione Peroxidase Activity, Serum Selenium Concentration, and Plasma Total Antioxidant Capacity in Cats with IRIS Stages I–IV Chronic Kidney Disease

Plasma and Erythrocyte Glutathione Peroxidase Activity, Serum Selenium Concentration, and Plasma Total Antioxidant Capacity in Cats with IRIS Stages I–IV Chronic Kidney Disease

Proteome Analysis of Oxidative Stress: Glutathionyl Hemoglobin in Diabetic and Uremic Patients

Ligand reaction‐based fluorescent peptide probes for the detection of Cu²⁺ and glutathione

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Glutathione antioxidant system as a marker of oxidative stress in chronic renal failure

Cited by 343 publications

References 41 publications

Plasma and Erythrocyte Glutathione Peroxidase Activity, Serum Selenium Concentration, and Plasma Total Antioxidant Capacity in Cats with IRIS Stages I–IV Chronic Kidney Disease

Plasma and Erythrocyte Glutathione Peroxidase Activity, Serum Selenium Concentration, and Plasma Total Antioxidant Capacity in Cats with IRIS Stages I–IV Chronic Kidney Disease

Proteome Analysis of Oxidative Stress: Glutathionyl Hemoglobin in Diabetic and Uremic Patients

Ligand reaction‐based fluorescent peptide probes for the detection of Cu2+ and glutathione

Contact Info

Product

Resources

About

Ligand reaction‐based fluorescent peptide probes for the detection of Cu²⁺ and glutathione