2016
DOI: 10.1523/jneurosci.0587-16.2016
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: The blood-brain barrier is a highly selective anatomical and functional interface allowing a unique environment for neuro-glia networks. Blood-brain barrier dysfunction is common in most brain disorders and is associated with disease course and delayed complications. However, the mechanisms underlying blood-brain barrier opening are poorly understood. Here we demonstrate the role of the neurotransmitter glutamate in modulating early barrier permeability in vivo. Using intravital microscopy, we show that recurr… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

5
108
0
2

Year Published

2017
2017
2022
2022

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 134 publications
(115 citation statements)
references
References 68 publications
5
108
0
2
Order By: Relevance
“…The observation of BBBD in dogs with recurrent seizures over several years may suggest the existence of enduring vascular abnormality, which may continue to support epileptogenesis. Alternatively, or additionally, BBBD during the interictal period may result from recurrent subclinical seizures and glutamate spillover . Interestingly, analysis of nine brain regions separately revealed a significant difference in BBBD score between IE and control dogs only in the piriform lobe, similarly to what has been described in SE‐induced rats .…”
Section: Discussionsupporting
confidence: 63%
“…The observation of BBBD in dogs with recurrent seizures over several years may suggest the existence of enduring vascular abnormality, which may continue to support epileptogenesis. Alternatively, or additionally, BBBD during the interictal period may result from recurrent subclinical seizures and glutamate spillover . Interestingly, analysis of nine brain regions separately revealed a significant difference in BBBD score between IE and control dogs only in the piriform lobe, similarly to what has been described in SE‐induced rats .…”
Section: Discussionsupporting
confidence: 63%
“…ATP-binding cassette (ABC) transporters expressed at the luminal side of the BBB prevent brain accumulation of drugs, xenobiotic agents and drug conjugates, via active efflux from endothelium into blood 6,17 . CMT facilitates CNS-to-blood clearance of excitatory amino acids (such as glutamate and aspartate) 18 , whereas RMT clearance of amyloid-β (Aβ, some forms of which are associated with AD) 6,1925 across the BBB keeps brain levels of these potentially toxic substances low (FIG. 2).…”
Section: The Bbb Molecular Architecturementioning
confidence: 99%
“…Brain disorders such as depression, anxiety, and dementia are eight times more common in epilepsy patients than in the general population . With growing evidence of microvascular dysfunction in epileptic tissue, the role of blood–brain barrier (BBB) injury in seizure disorders is gaining particular interest . BBB dysfunction and subsequent infiltration of serum albumin into the brain were shown to initiate epileptogenic alterations such as astrocytic transformation, neuroinflammation, excitatory synaptogenesis, and pathological plasticity .…”
Section: Introductionmentioning
confidence: 99%