2020
DOI: 10.1101/2020.03.20.000968
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Abstract: Dietary intervention has received considerable attention as an approach to extend lifespan and improve aging. However, questions remain regarding optimal dietary regime and underlying mechanism of lifespan extension. Here, we asked how glucose-enriched food extends the lifespan of Drosophila. We showed that glucose-dependent lifespan extension is independent of caloric restriction, or insulin activity, two established mechanisms of lifespan extension. Instead, we found that flies raised on glucoseenriched food… Show more

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Cited by 2 publications
(1 citation statement)
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“…Our results also show that intake of a sugar-rich blood meal increases the survival of L . longipalpis , a phenomenon that has already been reported for Drosophila [ 46 ]. Dietary glucose additionally enhanced immunity against enteric infections with the Gram-negative Vibrio cholerae bacteria in adult Drosophila [ 47 ].…”
Section: Discussionmentioning
confidence: 73%
“…Our results also show that intake of a sugar-rich blood meal increases the survival of L . longipalpis , a phenomenon that has already been reported for Drosophila [ 46 ]. Dietary glucose additionally enhanced immunity against enteric infections with the Gram-negative Vibrio cholerae bacteria in adult Drosophila [ 47 ].…”
Section: Discussionmentioning
confidence: 73%