Glucose biosensing based on a hydrogel optical fiber immobilized with glucose oxidase

Bian, Zhenglan; Yue, Qi; Li, Xue; Hu, Anduo; Yang, Hui; Chu, Fenghong

doi:10.1016/j.ijleo.2022.168655

Cited by 7 publications

(5 citation statements)

References 21 publications

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“…While designing the fluorescent‐based sensing chemistry for glucose, we defined the requirements relevant to our application. In particular, compared to the example fibers available in the literature aiming to improve the detection sensitivity, [ 36 ] we focused more on designing a method characterized by a good signal variation in response to the glucose concentration aiming to improve the robustness of the quantification. This choice was possible considering that the sensitivity required for wound application is in the m m range (0–10 m m ); moreover, compared to the sophisticated fabricating procedures proposed in the literature, [ 37 ] we intended to keep the synthetic procedure simple to ensure the cost‐efficacy of the sensing fiber.…”

Section: Resultsmentioning

confidence: 99%

Lab‐on‐a‐Fiber Wearable Multi‐Sensor for Monitoring Wound Healing

Giovannini,

Sharma,

Boesel

et al. 2023

Adv Healthcare Materials

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Chronic wounds are regarded as a silent epidemic, affecting 1–2% of the population and representing 2–4% of healthcare expenses. The current methods used to assess the wound healing process are based on the visual evaluation of physical parameters. This work aims to design a wearable non‐invasive device capable of evaluating three parameters simultaneously: the pH and the levels of glucose and matrix metalloproteinase (MMP) present in the wound exudate. The device is composed of three independent polymer optical fibers functionalized with fluorescent‐based sensing chemistries specific to the targeted analytes. Each fiber is characterized in terms of detection sensitivity and selectivity confirming their suitability for monitoring the targeted parameters in ranges relevant to the wound environment. The selectivity and robustness of the multi‐sensing device are confirmed with analyses using complex solutions with different pH levels (5, 6, and 7), different concentrations of glucose (1.25, 2.5, and 5 mm), and MMP (1.25, 2.5, and 5 µg mL−1). Given the simple set‐up, the affordability of the materials used and the possibility of detecting additional parameters relevant to wound healing, such multi‐sensing fiber‐based devices could pave the way for novel non‐invasive wearable tools enabling the assessment of wound healing from the molecular perspective.

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Section: Resultsmentioning

confidence: 99%

Lab‐on‐a‐Fiber Wearable Multi‐Sensor for Monitoring Wound Healing

Giovannini,

Sharma,

Boesel

et al. 2023

Adv Healthcare Materials

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“…Owing to their flexibility, lightweight, and resistance to electromagnetic interference, OGFs are widely used in sensitive, rapid responsible, and high-capacity communication networks. [264][265][266] They are particularly useful in shortdistance biomedical engineering such as health care services and medical implants. 267 Recently, Wang et al 268 presented a design strategy to prepare an exceptional electrical, optical, and mechanical self-healing poly(PDES) optical fiber (CPOF) with core-cladding structure and achieve continuous spinning via enhancing density of reversible non-covalent bond and polymer segmental mobility of poly(deep eutectic solvent polymerizable) (PDES) (Figure 13A).…”

Section: Optical Gel Fibersmentioning

confidence: 99%

“…Therefore, there is a need for biopolymer‐based optical fibers that incorporate nontoxic luminescent nanomaterials as well as environmentally friendly and efficient extrusion methods. Owing to their flexibility, lightweight, and resistance to electromagnetic interference, OGFs are widely used in sensitive, rapid responsible, and high‐capacity communication networks 264–266 . They are particularly useful in short‐distance biomedical engineering such as health care services and medical implants 267 .…”

Section: Functionalities and Applications Of Gel Fibersmentioning

confidence: 99%

Innovations in spider silk‐inspired artificial gel fibers: Methods, properties, strengthening, functionality, and challenges

Khan,

Guo,

et al. 2024

SusMat

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Spider silk, possessing exceptional combination properties, is classified as a bio‐gel fiber. Thereby, it serves as a valuable origin of inspiration for the advancement of various artificial gel fiber materials with distinct functionalities. Gel fibers exhibit promising potential for utilization in diverse fields, including smart textiles, artificial muscle, tissue engineering, and strain sensing. However, there are still numerous challenges in improving the performance and functionalizing applications of spider silk‐inspired artificial gel fibers. Thus, to gain a penetrating insight into bioinspired artificial gel fibers, this review provided a comprehensive overview encompassing three key aspects: the fundamental design concepts and implementing strategies of gel fibers, the properties and strengthening strategies of gel fibers, and the functionalities and application prospects of gel fibers. In particular, multiple strengthening and toughening mechanisms were introduced at micro, nano, and molecular‐level structures of gel fibers. Additionally, the existing challenges of gel fibers are summarized. This review aims to offer significant guidance for the development and application of artificial gel fibers and inspire further research in the field of high‐performance gel fibers.

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“…However, expensive costs and complex operational procedures of these instruments restrict practical applications. Consequently, various chemical substances that could bind with 1, 2- cis -diol groups of glucose in solution were reported, including glucose oxidase (GOx), , concanavalin A (Con A), − and phenylboronic acid (PBA), − and some chemical sensors based on these substances have been reported, such as fluorescence sensors, − electrochemical sensors, − gels, − and photonic crystals. − In the past few decades, blood glucose meters based on an electrochemistry method and glucose oxidase have been widely commercialized, but this does not mean that this analysis method is perfect. First, the characteristic of inactivation of the glucose oxidase makes the accuracy of blood glucose meters to be influenced by environmental factors such as temperature, humidity, and altitude .…”

Section: Introductionmentioning

confidence: 99%

One-Dimensional Responsive Photonic Crystals Assembled by Polymer Nanogels and TiO₂ Nanoparticles for Rapid Detection of Glucose

Shi,

Kou,

Gao

et al. 2024

ACS Appl. Nano Mater.

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Diabetes, characterized by chronic hyperglycemia, has become a major threat to human health. A noninvasive, continuous, and rapid visual detection of glucose is still a challenge in application. In this study, one-dimensional photonic crystals (1DPCs) prepared via layer-by-layer assembling of glucose-responsive poly(acrylamide-N,N'-methylenebis(acrylamide)-3acrylamide phenylboronic acid) (P(AM-MBA-AAPBA)) nanogels and TiO 2 nanoparticles are first confirmed for rapid and continuous colorimetric detection of glucose in physiological conditions. A two-step swelling mechanism of PCs was designed to speed up glucose diffusion and recognition. In detection, the PC sensor with a thickness of about 200 nm can rapidly imbue the polymer layer with water, causing the polymer layer to swiftly swell and create a pathway for mass transfer. Then, glucose molecules permeate in PC's channels and bind to phenylboronic acid (PBA) sites, prompting secondary expansion. Due to the inherent hydrophilicity of the polymer and the nanoporous structure of the TiO 2 layer, PC sensors exhibit exceptional responsiveness, reaching sensing equilibrium in glucose solution within 40 s and quickly reverting to their initial state within 1 s after adding diluted hydrochloric acid. The PC sensor effectively generates optical signals across a broad glucose concentration range of 0−100 mM and realizes continuous glucose detection. Notably, they can indicate the risk of diabetes with artificial urine, which provides a strategy for noninvasive glucose detection. In addition, the adsorption and desorption processes of glucose on PC are monitored with a quartz crystal microbalance with dissipation, and the reversible swelling of the nanogel layer is revealed, which provides valuable references for the mechanism study of PC glucose sensors.

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Glucose biosensing based on a hydrogel optical fiber immobilized with glucose oxidase

Cited by 7 publications

References 21 publications

Lab‐on‐a‐Fiber Wearable Multi‐Sensor for Monitoring Wound Healing

Lab‐on‐a‐Fiber Wearable Multi‐Sensor for Monitoring Wound Healing

Innovations in spider silk‐inspired artificial gel fibers: Methods, properties, strengthening, functionality, and challenges

One-Dimensional Responsive Photonic Crystals Assembled by Polymer Nanogels and TiO₂ Nanoparticles for Rapid Detection of Glucose

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Glucose biosensing based on a hydrogel optical fiber immobilized with glucose oxidase

Cited by 7 publications

References 21 publications

Lab‐on‐a‐Fiber Wearable Multi‐Sensor for Monitoring Wound Healing

Lab‐on‐a‐Fiber Wearable Multi‐Sensor for Monitoring Wound Healing

Innovations in spider silk‐inspired artificial gel fibers: Methods, properties, strengthening, functionality, and challenges

One-Dimensional Responsive Photonic Crystals Assembled by Polymer Nanogels and TiO2 Nanoparticles for Rapid Detection of Glucose

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Product

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One-Dimensional Responsive Photonic Crystals Assembled by Polymer Nanogels and TiO₂ Nanoparticles for Rapid Detection of Glucose