Glucocorticoids and circadian clock control of cell proliferation: At the interface between three dynamic systems

Dickmeis, Thomas; Foulkes, Nicholas S.

doi:10.1016/j.mce.2010.09.001

Cited by 44 publications

(33 citation statements)

References 178 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glucocorticoids promote synaptic development, neuronal plasticity (Liston and Gan 2011), and cell proliferation, and themselves have the capacity for resetting circadian oscillators in peripheral tissues (Balsalobre et al 2000a;Dickmeis and Foulkes 2011). Diurnal release of glucocorticoids occurs in synchrony with the animal's activity cycle (Dickmeis and Foulkes 2011).…”

Section: Mechanisms Linking the Circadian Clock And Memorymentioning

confidence: 99%

See 1 more Smart Citation

Synchrony and desynchrony in circadian clocks: impacts on learning and memory

Krishnan

Lyons

2015

Learn. Mem.

View full text Add to dashboard Cite

Circadian clocks evolved under conditions of environmental variation, primarily alternating light dark cycles, to enable organisms to anticipate daily environmental events and coordinate metabolic, physiological, and behavioral activities. However, modern lifestyle and advances in technology have increased the percentage of individuals working in phases misaligned with natural circadian activity rhythms. Endogenous circadian oscillators modulate alertness, the acquisition of learning, memory formation, and the recall of memory with examples of circadian modulation of memory observed across phyla from invertebrates to humans. Cognitive performance and memory are significantly diminished when occurring out of phase with natural circadian rhythms. Disruptions in circadian regulation can lead to impairment in the formation of memories and manifestation of other cognitive deficits. This review explores the types of interactions through which the circadian clock modulates cognition, highlights recent progress in identifying mechanistic interactions between the circadian system and the processes involved in memory formation, and outlines methods used to remediate circadian perturbations and reinforce circadian adaptation.Circadian clocks permit organisms to anticipate recurring daily environmental events through the coordination of metabolic, physiological, and behavioral rhythms. Conservation of the core principles through which circadian oscillators are organized across eukaryotic phyla suggests strong selective pressures for both circadian clocks and the mechanisms through which circadian oscillators operate. Intracellularly, transcription/translation feedback loops involving core circadian components set the stage for transcriptional regulation of thousands of genes in individual cells and tissues (Balsalobre et al.

show abstract

Section: Mechanisms Linking the Circadian Clock And Memorymentioning

confidence: 99%

“…Diurnal release of glucocorticoids occurs in synchrony with the animal's activity cycle (Dickmeis and Foulkes 2011). In mice, training during peak glucocorticoid levels increases learning-induced spine formation, while training during the circadian trough does not (Liston et al 2013).…”

Section: Mechanisms Linking the Circadian Clock And Memorymentioning

confidence: 99%

Synchrony and desynchrony in circadian clocks: impacts on learning and memory

Krishnan

Lyons

2015

Learn. Mem.

View full text Add to dashboard Cite

show abstract

“…RORa is a nuclear receptor involved in both lipogenesis and lipid storage, which can activate Bmal1 transcription (26). Glucocorticoids (GC) and its receptor (GR) have also been identified as an important link between circadian clocks and nutrients (27). Studies have shown that liver-specific GR mutation display accelerated phase shifting in response to restricted feeding schedule in daytime (28), while injection of corticosterone do not cause the phase shifting induced by restricted feeding (29).…”

Section: The Connection Between Nutrients and Circadian Rhythmsmentioning

confidence: 99%

Nutrients and Circadian Rhythms in Mammals

Yao

Huang

et al. 2015

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

In mammals, the approximate 24-h rhythm in behavior and physiology is generally existed, such as wake/ sleep cycle, blood pressure, body temperature and concentration of melatonin. The circadian rhythms result from the cell-autonomous and self-sustained oscillators (circadian clocks), which rely on interlocking transcription/translational feedback loops involving a series of clock genes (Clock, Bmal1, Per, Cry, Dec etc.) and their proteins (1). The mammalian circadian clocks are composed of a master clock located in the hypothalamic suprachiasmatic nucleus (SCN), and of many peripheral clocks in tissues and extra-SCN brain regions (2). The master clock is mainly entrained by the light cue, while the peripheral clocks are not only affected by the SCN clock but also entrained by the food cue (3). Moreover, feeding could take over part of the SCN signaling, and affect internal synchrony between the master clock and the peripheral clocks. Nutrient Components and Circadian RhythmsNutrient components have been identified as important factors to entrain the peripheral circadian clocks (4).Glucose is a particularly potent entraining factor for peripheral clocks (5). Min-Dian Li et al. found that high concentration of glucose increased the transcription levels of Bmal1 and Cry1 genes without the alteration of the phase of Bmal1 cycling, and low concentration of glucose delayed the phase of BMAL1 protein accumulation via western blot (6). How could glucose influence the circadian clock and further affect the following metabolic process aroused extensive attention. Some researchers revealed that cellular nutrient sensors such as nuclear receptors were proposed as candidates for the circadian clock entrainment by nutrient components (7,8). A recent study showed that the O-GlcNAc signaling entrained the circadian clock by inhibiting BMAL1/ CLOCK ubiquitination, which may be the molecular mechanism underlying the glucose entrainment of the circadian clock (6).Intraperitoneal injection of amino acids combined with glucose delayed the phase of the liver clock as similar as the effect of delayed feeding (9). l-carnosine is a dipeptide of the amino acids b-alanine and l-histidine, which is identified to be related with various physiological alterations (including blood glucose, blood pressure etc.) through the autonomic nerves. Bilateral lesions of the SCN in rat results in destructive effects on the carnosine induced physiological alterations mentioned above (10). In our study, we found that l-carnosine administration could accelerate the resetting rate of peripheral clock genes in the hearts, which is regulated by the autonomic nervous system (11).Alcohol is another entraining factor for circadian clocks. Chronic alcohol administration induced the hepatic steatosis and disturbed the circadian clocks in the liver (12). Studies in human indicated that the expression level of clock genes in leukocytes of male alcoholic patients were lower than the healthy men (13). Timed Nutrients and Circadian RhythmsTimed nutrients are as impor...

show abstract

“…Glucocorticoids (GCs) are steroid hormones derived from the adrenal gland which function in a wide array of physiological processes, including inflammation, glucose homeostasis, and cell proliferation [68]. Their anti-inflammatory effects are exploited pharmaceutically to combat pain, allergies, arthritis as well as lymphomas and leukemia.…”

Section: Glucocorticoidsmentioning

confidence: 99%

“…The outcome of GC signaling is tissue-specific and likewise the effect of GC signaling in cancerous cells depends on the type; pro-apoptotic in certain cancers, but pro-survival and promoting resistance to cell death in others [68,74]. In obesity, GCs also have pleiotropic effects but generally promote fat deposition.…”

Section: Glucocorticoidsmentioning

confidence: 99%

Relevance of Circadian Rhythm in Cancer

DiTacchio

Panda

2015

Energy Balance and Cancer

View full text Add to dashboard Cite

Circadian rhythms are patterns of behavior, physiology, and metabolism that occur within a period of approximately 24 h. These rhythms are generated endogenously, but synchronize to external cues, thus enabling organisms to beneficially align physiological processes to the inherently dynamic, yet predictable, seasonal changes in the day-night cycle. The cell autonomous circadian oscillator temporally coordinates cellular processes, including metabolism, proliferation, cell signaling, organelle function, proteostasis, and DNA damage repair to sustain cellular homeostasis. It is hypothesized that the circadian oscillators evolved as a "flight from light" mechanism to minimize UV damage to single stranded DNA by restricting DNA replication to the nighttime. Support for this hypothesis is accumulating with the recent observation that the circadian rhythm and cell cycle are intimately coupled to each other, so that specific phases of cell cycle occur at a defined phase of the circadian oscillator at single-cell level [1]. Furthermore, chronic circadian disruption perturbs cellular homeostasis and predisposes to cancer. Conversely, numerous cancer cell lines display severe circadian alterations, which likely contribute to aggressive proliferation of the tumor. Hence, it is becoming increasingly important to understand the relevance of circadian rhythm for optimizing fitness

show abstract

Glucocorticoids and circadian clock control of cell proliferation: At the interface between three dynamic systems

Cited by 44 publications

References 178 publications

Synchrony and desynchrony in circadian clocks: impacts on learning and memory

Synchrony and desynchrony in circadian clocks: impacts on learning and memory

Nutrients and Circadian Rhythms in Mammals

Relevance of Circadian Rhythm in Cancer

Contact Info

Product

Resources

About