Glucocorticoid response to exercise as measured by serum and salivary cortisol

Stupnicki, Romuald; Obmiński, Zbigniew

doi:10.1007/bf00602363

Cited by 48 publications

(30 citation statements)

References 9 publications

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“…The collection procedure is easy, non-invasive, stress free, and it can be applied under a variety of field settings. Salivary levels accurately reflect the unbound, biologically active, hormonal fraction in the general circulation (Riad-Fahmy et al 1987;Vining et al 1983); pertinently, an excellent correlation was found between serum and salivary levels of cortisol as a response to an acute bout of maximal exercise (O'Connor and Corrigan 1987;Port 1991;Stupnicki and Obminski 1992;Thuma et al 1995).…”

Section: Introductionmentioning

confidence: 93%

Differential responses of serum and salivary interleukin-6 to acute strenuous exercise

et al. 2004

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Physical exercise is associated with elevation of serum levels of interleukin-6 (IL-6) because of its production in the muscles. The use of IL-6 measurements in saliva has been proposed in the field of immunopathology, mainly involving salivary gland disease. We evaluated the responses of serum and salivary IL-6 in two different groups of athletes submitted to different types of controlled strenuous exercise (spinning activity and maximal isokinetic test). Serum and salivary samples for IL-6 measurements, and serum samples for lactate and myoglobin determination before and after exercise, were obtained. Salivary IL-6 was measured by ELISA after dilution experiments and compared with results obtained by immunoradiometric assay. Spinning activity elicited significant increases in all the variables, and no correlation was found among the respective variations. A significant response to the isokinetic exercise was observed for serum IL-6, lactate and myoglobin only; no correlation was found between serum and salivary IL-6. Our study demonstrated that serum and salivary IL-6 responses to exercise are dissociated, possibly in relation to the lack of relationships between the systemic/muscular and the salivary routes of IL-6 production. Analytical issues that concern IL-6 measurement in saliva deserve attention, notably regarding the collection method used to absorb saliva. Concomitant monitoring of serum markers of inflammation, muscle metabolism and damage can provide information about muscle function properties and adaptations to physical effort in different types of athletes.

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Section: Introductionmentioning

confidence: 93%

Differential responses of serum and salivary interleukin-6 to acute strenuous exercise

et al. 2004

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“…Despite these associations, we are aware of few investigations directly comparing plasma and salivary IL-6 concentrations (Minetto et al 2005;Minetto et al 2007). If salivary IL-6 concentrations provide a valid representation of plasma IL-6, in the same way that salivary cortisol is accepted as reXecting free (unbound) plasma cortisol concentrations (Stupnicki and Obminski 1992), then this would oVer an alternative to the invasive collection procedures currently required for monitoring IL-6 responses to exercise. Minetto et al (2005) examined plasma and salivary IL-6 concentrations in a small sample (n = 7) of athletes from varying sports.…”

Section: Introductionmentioning

confidence: 99%

Resting plasma and salivary IL-6 concentrations are not correlated in distance runners

Cox

Pyne

Gleson³

et al. 2008

Eur J Appl Physiol

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Measurement of IL-6 has been widely undertaken to examine inflammatory and immune responses to exercise. Use of salivary IL-6 offers an alternative to the invasive collection procedures required for IL-6 measurement in plasma samples. Rarely, however, has the degree of association between plasma and salivary IL-6 been reported. The aim of the current study was to investigate the relationship between resting salivary and plasma IL-6 concentrations in 45 trained distance runners (36 males, 9 females; age: 35.1 +/- 8.0 y, mean +/- SD). Plasma and saliva samples were collected from athletes under resting conditions. Plasma IL-6 concentrations were determined using a Bioplex suspension array system and commercially available reagents. Salivary IL-6 concentrations were determined using a commercially available high-sensitivity ELISA kit. At rest, the mean (+/- SD) plasma IL-6 concentration was 3.43 +/- 3.75 pg mL(-1) compared to a mean salivary IL-6 concentration of 1.80 +/- 4.25 pg mL(-1). IL-6 concentrations in plasma and saliva samples were not correlated (r = -0.031, p = 0.85). At rest, salivary IL-6 concentrations do not reflect plasma IL-6 concentrations. The potential for salivary IL-6 to act as a surrogate marker for plasma IL-6 responses when examining inflammatory and immune responses to exercise, therefore, appears unlikely.

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“…While this seems a robust finding in individuals with established CFS, without prospective studies of individuals at high risk of developing CFS it is difficult to tell whether such changes play a causal role, or are a result of downstream factors such as sleep, deconditioning or circadian rhythm disruption (Spath Schwalde et al 1992;Stupnicki & Obminski, 1992 ;Leese et al 1996).…”

Section: Introductionmentioning

confidence: 99%

Predictors of fatigue following the onset of infectious mononucleosis

et al. 2003

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Background. Infectious mononucleosis (IM) is a risk factor for chronic fatigue. Reduced activity is the most consistent factor found to be associated with poor outcome following the onset of infectious mononucleosis. However, little is known about the biological mechanisms involved in the pathogenesis of chronic fatigue following IM and no study, so far, has examined the relation between certain illness beliefs and poor outcome. This study explored immunological, endocrine, behavioural and cognitive responses to the acute illness and assessed which components of these groups of risk factors predicted a chronic course.

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Glucocorticoid response to exercise as measured by serum and salivary cortisol

Cited by 48 publications

References 9 publications

Differential responses of serum and salivary interleukin-6 to acute strenuous exercise

Differential responses of serum and salivary interleukin-6 to acute strenuous exercise

Resting plasma and salivary IL-6 concentrations are not correlated in distance runners

Predictors of fatigue following the onset of infectious mononucleosis

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