2015
DOI: 10.1002/art.39069
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Abstract: Objective Mesenchymal stem cells (MSCs) are potent immunosuppressive cells that have shown promise in the treatment of rheumatoid arthritis (RA). Deciphering the intrinsic characteristics of MSCs that correlate with their biologic activity will facilitate their clinical use. Recently, the role of glucocorticoid‐induced leucine zipper (GILZ) in the development of RA has been documented. The aim of this study was to evaluate whether GILZ expression by MSCs may contribute to their therapeutic effect. Methods MSCs… Show more

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Cited by 39 publications
(40 citation statements)
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“…In contrast, PPARβ/δ −/− MSCs significantly reduced the clinical signs of arthritis of the injected mice compared with mice of the control group (CIA) or the group treated with PPARβ/δ +/+ MSCs (figure 2A). In the same experiment, we observed that MSCs isolated from C57BL/6 mice were able to decrease the clinical score of arthritis as previously reported (figure 2A) 17 29. As expected on the basis of the clinical score, histological analysis of the synovial membrane, bone and cartilage revealed the presence of large amounts of inflammatory cells and areas of bone erosion in control and PPARβ/δ +/+ MSCs-treated mice and not in C57BL/6 and PPARβ/δ −/− MSCs-treated mice (figure 2B).…”
Section: Resultssupporting
confidence: 87%
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“…In contrast, PPARβ/δ −/− MSCs significantly reduced the clinical signs of arthritis of the injected mice compared with mice of the control group (CIA) or the group treated with PPARβ/δ +/+ MSCs (figure 2A). In the same experiment, we observed that MSCs isolated from C57BL/6 mice were able to decrease the clinical score of arthritis as previously reported (figure 2A) 17 29. As expected on the basis of the clinical score, histological analysis of the synovial membrane, bone and cartilage revealed the presence of large amounts of inflammatory cells and areas of bone erosion in control and PPARβ/δ +/+ MSCs-treated mice and not in C57BL/6 and PPARβ/δ −/− MSCs-treated mice (figure 2B).…”
Section: Resultssupporting
confidence: 87%
“…The frequency of Th1 cells was significantly lower only in the blood of mice treated with PPARβ/δ −/− MSCs as compared with the three other groups of mice. Since pathogenic Th17 cells are also characterised by their capacity to produce granulocyte-macrophage colony-stimulating factor (GM-CSF),29 33 we quantified GM-CSF in the supernatant of bCII-stimulated dLN cells isolated from untreated CIA control mice or mice treated with MSCs. The cells from the dLNs of mice treated with either PPARβ/δ +/+ - GSK3787 MSCs or PPARβ/δ −/− MSCs produced significantly lower levels of GM-CSF than those of CIA mice or mice treated with PPARβ/δ +/+ MSCs (figure 3C).…”
Section: Resultsmentioning
confidence: 99%
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“…It also remains possible that GILZ deficiency induces autoimmunity via effects on cells additional to B cells, as exemplified by recently reported T cell intrinsic effects of GILZ on Th17 differentiation and on mesenchymal stem cell regulation of the same pathway 70 71. However, here we have uncovered an essential, B cell-intrinsic role for GILZ in preventing B cell-mediated autoimmunity.…”
Section: Discussionmentioning
confidence: 49%