2004
DOI: 10.1001/archderm.140.8.971
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Glomuvenous Malformation (Glomangioma) and Venous Malformation

Abstract: To develop clinical criteria that permit clinical distinction between inherited glomuvenous malformation (GVM), known as glomangioma, and inherited cutaneomucosal venous malformation and to test these criteria on sporadic lesions.Design: Clinical data were compiled for 1685 patients with inherited or sporadic cutaneous venous anomalies. Based on a cohort of patients with a mutation in the TIE2 or glomulin gene or a histologic diagnosis, we defined clinical criteria for inherited GVM and cutaneomucosal venous m… Show more

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Cited by 280 publications
(250 citation statements)
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“…Additional parameters showed marked improvements across patients (Table 3 and Supplemental Table 3), albeit statistically inconclusive due to the limited sample size. Biological parameters were as follows: D-dimer levels dropped (from 6,723.5 [1,110] ng/ml to 1,085.0 [884-1,441] ng/ ml) between the initiation of therapy (start) and the 12-month time point (Table 3 and Figure 8). Fibrinogen levels normalized in the 1 patient in whom they were abnormal and increased in all patients except patient 4 (from 265.5 [205-371] mg/dl to 340.0 [260.5-397.5] mg/dl) over the same time period.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Additional parameters showed marked improvements across patients (Table 3 and Supplemental Table 3), albeit statistically inconclusive due to the limited sample size. Biological parameters were as follows: D-dimer levels dropped (from 6,723.5 [1,110] ng/ml to 1,085.0 [884-1,441] ng/ ml) between the initiation of therapy (start) and the 12-month time point (Table 3 and Figure 8). Fibrinogen levels normalized in the 1 patient in whom they were abnormal and increased in all patients except patient 4 (from 265.5 [205-371] mg/dl to 340.0 [260.5-397.5] mg/dl) over the same time period.…”
Section: Discussionmentioning
confidence: 99%
“…Venous malformations (VMs) are composed of ectatic and distorted veins surrounded by sparse and irregularly distributed smooth muscle cells (1,2). VMs form compressible bluish lesions that are usually present at birth and continue to grow with the child.…”
Section: Introductionmentioning
confidence: 99%
“…Approximately 93 % of VMs progress over lifetime with pain and swelling being the most common symptoms [2]. Lesions can be multifocal, but the singular spongiform type is the most common type [24]. Treatment of spongiform VMs with sclerotherapy technically has a success rate of close to 100 % [25].…”
Section: Discussionmentioning
confidence: 99%
“…Las lesiones pueden ser localizadas, diseminadas o metaméricas y se manifiestan como lesiones nodulares o en forma de placas, rosadas o azul oscuras, con una apariencia en empedrado y a veces áreas hiperqueratósicas. Clínicamente se diferencian de las malformaciones venosas porque las glomuvenosas se encuentran limitadas a la piel y al tejido celular subcutáneo, nunca son infiltrantes, no son compresibles, no se vacían levantándolas por encima del corazón, no tienen flebolitos y no asocian alteraciones de la coagulación 14 . De hecho, hoy en día la tendencia es a clasificarlas como un grupo diferente a las malformaciones venosas.…”
Section: Cuadros Con Entidad Propiaunclassified