Glomus caroticum tumors: A case report of an operated giant carotid body tumor with a review of our experience in 47 patients

Talay, Süreyya; Abanoz, Mustafa; Kayğın, Mehmet Ali; Dağ, Özgür; Halıcı, Ümit; Ay, Derih; Yücel, Semih Murat; Kabalar, Mehmet Eşref; Tasmacioglu, Buket; Erkut, Bilgehan

doi:10.2478/s11536-010-0015-8

Cited by 5 publications

(3 citation statements)

References 16 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Paragangliomas located at the carotid bifurcation are known as carotid body tumors, and are extremely rare with a reported incidence of 1-2/100,000. They account for 0.012% of all body tumors and 0.5% of head and neck tumors [12][13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Carotid body paraganglioma metastatic to spine causing cord compression: a case report

et al. 2023

View full text Add to dashboard Cite

Background Carotid body tumors (CBTs) are rare neuroendocrine neoplasms arising near the carotid bifurcation with a reported incidence of 1 to 2 cases in 100,000 patients. Most CBTs are sporadic, benign, slow-growing, and non-secreting, but untreated CBTs can grow locally to compress the nearby blood vessels, esophagus, and airway. Regional metastases can occur in 5% to 10% of cases, but distant metastases are exceedingly rare, occurring in roughly 1–2% of cases. As such, the optimal treatment for metastatic CBTs is not well-defined. We report a rare case of a patient with CBT distant metastases causing spinal cord compression. Case presentation A 40-year-old African American female presented with a right neck mass, headaches, vertigo, tinnitus, hoarseness, and dysphagia. Imaging demonstrated a Shamblin II right neck mass; subsequent transcervical resection and pathology showed a carotid body paraganglioma. The patient recurred locally near the carotid bifurcation, so she underwent Stereotactic Body Radiation Therapy to the recurrent right neck disease. She later re-presented with new onset bilateral lower extremity weakness, dysmetria, and numbness. She was found to have metastatic disease to the thoracic spine causing spinal cord compression. She underwent laminectomy, tumor resection, and posterior fixation followed by adjuvant radiation therapy. She was started on systemic therapy with sunitinib. She eventually progressed with metastatic disease to the right iliac bone, which was treated with palliative radiotherapy. Second line systemic therapy with capecitabine and temozolomide was started. At last follow up, the patient was asymptomatic with stable persistent disease. Conclusions Paragangliomas often exhibit a prolonged interval to the development of progression; locoregional recurrences or rare distant metastases have been reported to occur as many as 20 years from diagnosis. The natural course of CBTs in other cases as well as the present case call into question the idea that CBTs are truly benign; instead CBTs may be indolent tumors with metastatic potential. Treatment choices for CBTs include surgical resection, radiation therapy, and systemic therapy, though the optimal treatment regimen for metastatic CBTs is not well-defined. A more advanced understanding of CBT pathophysiology, disease classification, risk stratification, and treatment options is needed to improve outcomes for patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Carotid body paraganglioma metastatic to spine causing cord compression: a case report

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The series conducted by Talay et al (15), including 47 cases, is the most comprehensive series with results on glomus tumors that has been published in our country. Although our cases were type 3 according to Shamblin's classification, tumoral mass resection could be performed through the surgical technique that we administered without the need for graft interposition.…”

Section: Discussionmentioning

confidence: 99%

Protective Surgical Procedures for Carotid Body Tumors: A Case Series

Toktaş¹,

Yümün²,

Gücü³

et al. 2014

Erciyes Med J

View full text Add to dashboard Cite

Glomus tumors are benign tumors that originate from neural non-chromaffin cells. Its symptoms usually depend on the mass effect. The tumor can be treated with embolization, excision, and radiotherapy. The most important complications of surgery are hemiplegia and nerve injury at the surgical site. In this article, we report four cases of carotid body tumor. Four female patients presented with neck swelling and/or hypertension, and the diagnosis was made with the aid of ultrasonography, angiography, and computed tomography. These cases were classified as type 3 according to Shamblin's classification, and surgical resection was performed under local anesthesia without the need for graft interposition. These tumors were excised with the carotid artery adventitia. No complication associated with the surgery was observed in any patient.

show abstract

“…Carotid body tumors (CBTs), also known as chemodectoma or carotid glomus tumors, are rare neuroendocrine neoplasms with a reported incidence of 1–2/100000 and account for 0.012% of all body tumors and 0.5% of head and neck tumors 1–5 . CBTs are derived from paraganglionic tissue, composed of chromaffin‐negative glomus cells originating from the neural crest.…”

Section: Introductionmentioning

confidence: 99%

Current trends in carotid body tumors: Comprehensive review

et al. 2022

View full text Add to dashboard Cite

Background: Carotid body tumor (CBT) is a rare neoplasm that has been increasingly studied during the last decades; nevertheless, it continues to be a topic of controversy. This review aims to provide an update on the general features of CBT and particularly review different treatment strategies and primary outcomes. Methods: Data for this literature review were identified by PubMed, Scopus, and Medline. 93 articles from the initial search were included, as well as 28 relevant studies utilizing the snowballing method; totaling 121 articles about CBT. Results: Main features such as anatomy, embryology, genetics, clinical presentation, and diagnosis of CBT are presented, followed by evidence of different treatment strategies such as radiotherapy, preoperative embolization, vascular resection, and vascular reconstruction. Main complications are also discussed. Conclusion:This review summarizes the most critical aspects regarding CBT. Future studies should compare different treatments to attain the best surgical results with lower morbidity rates.

show abstract

Glomus caroticum tumors: A case report of an operated giant carotid body tumor with a review of our experience in 47 patients

Cited by 5 publications

References 16 publications

Carotid body paraganglioma metastatic to spine causing cord compression: a case report

Carotid body paraganglioma metastatic to spine causing cord compression: a case report

Protective Surgical Procedures for Carotid Body Tumors: A Case Series

Current trends in carotid body tumors: Comprehensive review

Contact Info

Product

Resources

About