Abstract:Weak nonspecific immunological stimuli can irritate the glomerular mesangium as observed following administration of insulin preparations of varying degrees of purity. In the present study further substances were investigated with regard to this effect. We wished to examine which substances obtained during purification of insulin are mainly responsible for the antigenicity, and whether porcine and bovine MC insulin have the same antigenic properties. Rabbits were treated for up to 90 days with bovine MC insuli… Show more
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