Glomerular diseases in Iranian children: clinico-pathological correlations

Abstract

Glomerular disease constitutes an important part of renal disease. The purpose of this study was to describe and correlate the types of glomerular diseases reported in native kidney biopsy specimens and their clinical presentations in Iranian children. The medical records and pathological diagnoses of patients with glomerular disease whose native kidney biopsy specimens were received by our hospital during a 10-year period were reviewed. In each patient, pathological diagnosis, clinical presentation, age at onset of disease, gender, and presence of nephrotic proteinuria, hematuria, and hypertension, were determined. Minimal-change disease was the most frequent glomerular disease and nephrotic syndrome was the most frequent clinical presentation encountered. For each disease, correlations between the clinical presentation and pathological diagnosis were made. This study describes various glomerular diseases encountered in Iranian children, with their respective clinical presentations.

Relationship between Fractional Excretion of Magnesium and Renal Histology in Glomerulonephritis

“…Disease incidence was similar to the study by Madani A et al [7] (66.26%) and Al-Rasheed et al [14] (77%). In this study FEMg was normal in MCD (1.81±0.34%).…”

“…In children the most common presentation of glomerulonephritis is nephrotic syndrome [7]. Histologically minimal change disease (MCD) is the commonest 76.4%, other histological pattern are mesangial proliferative glomerulonephritis (MesPGN) 2.3%, membranoproliferative glomerulo nephritis (MPGN)7.5%, focal segmental glomerulosclerosis (FSGS) 6.9%, membranous nephropathy(MN) 1.5%.…”

Histopathological spectrum of childhood nephrotic syndrome in Pakistan

“…Kari [15], in a study from western Saudi Arabia, reported declining incidence of MCD and concomitant rise in the prevalence of FSGS [15]. Madani et al [16] observed MCD in 27.2% of biopsies from Iranian children.…”

“…These early studies showed that FSGS was a rare cause of INS in children, found in only 5-7% of biopsies [3][4][5][6]. Recent reports from many parts of the world, particularly the USA, suggest that the incidence of FSGS is on the rise in both adults and children [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. On the other hand, there is no information in international literature on the accurate pathology of childhood INS in Pakistan, particularly involving the use of IF and EM study of renal biopsies.…”

Natural History and Prognostic Factors of IgA Nephropathy Presented with Isolated Microscopic Hematuria in Chinese Patients

“…Nearly 70% of IgAN patients have no clinical symptoms except mild hematuria and/or proteinuria [7, 8]. In several Asian countries, application of renal biopsy is common, so IMH is frequently observed in IgANpatients [9,10,11].…”