Glomerular diseases in a Hispanic population: review of a regional renal biopsy database

Abstract

CONTEXT AND OBJECTIVE: Epidemiological data provide useful information for clinical practice and investigations. This study aimed to determine glomerular disease frequencies in a region of Colombia and it represents the basis for future studies. DESIGN AND SETTING:Single-center retrospective analysis at the University of Antioquia, Colombia. METHODS:All native renal biopsies (July 1998 to December 2007) were reviewed, but only glomerular diseases were analyzed. The diagnosis of each case was based on histological, immunopathological and clinical features.RESULTS: A total of 1,040 biopsies were included. In 302 cases (29.0%), the patient's age was ≤ 15 years. Primary glomerular diseases were diagnosed in 828 biopsies (79.6%) and secondary in 212 (20.4%). The most common primary diseases were focal and segmental glomerulosclerosis (FSGS) (34.8%), immunoglobulin A (IgA) nephropathy (IgAN) (11.8%), membranous glomerulonephritis (MGN) (10.6%), minimal change disease (MCD) (10.6%), crescentic glomerulonephritis (GN) (5.6%), and non-IgA mesangial proliferative GN (5.6%). Postinfectious GN represented 10.7% of the diagnoses if included as primary GN. Lupus nephritis corresponded to 17.8% of the entire series. In adults, the order of the most frequent primary diseases was: FSGS, IgAN, MGN, crescentic GN and MCD. In children (≤ 15 years), the most frequent were: FSGS, postinfectious GN, MCD, non-IgA mesangial proliferative GN, endocapillary diffuse GN and IgAN.CONCLUSIONS: As among Afro-Americans, FSGS is the most frequent type of glomerulopathy in our population, but in our group, there are more cases of IgAN. The reasons for these findings are unclear. This information is an important contribution towards understanding the prevalence of renal diseases in Latin America.

Comparative analysis of primary and secondary glomerulopathies in the northeast of Brazil: data from the Pernambuco Registry of Glomerulopathies - REPEG

“…Several studies of biopsy registries, especially in Latin America, have demonstrated a predominance of FSGS, ranging from 25% to 35%. 2,5,7,15,19 A high prevalence such as found in REPEG (43%), although unusual, was also observed in Mexico, and represented 47% of the biopsies.…”

A Systematic Review and Meta-analysis of Prevalence of Biopsy-Proven Lupus Nephritis

“…These 19 articles were published between 1994 and 2012, and included patients from 14 different countries. The included studies covered three study fields: five articles 9-13 described the prevalence rate of BPLN among patients with SLE (Table 1); nine articles [14][15][16][17][18][19][20][21][22] described the prevalence rate of BPLN among patients with SGD that were included in a renal biopsy database (Table 2); and six articles 13,[23][24][25][26][27] examined the prognosis of patients with BPLN, and investigated the factors associated with prognosis (Table 3). Two articles 15,19 were serial studies carried out from January 1990 to January 2002 and from January 2003 to October 2006, respectively, and were based on the same renal biopsy database in Bahrain; therefore, the data in these two studies were combined for the purposes of this analysis.…”

“…Similarly, the pooled prevalence rate of LN among patients with SLE in Europe and the USA was 31% (95% CI: 23-38%, I 2 = 93.8%, p<0.001), significantly lower than the single rate Table 1. Main characteristics of studies reporting on incidence of biopsy-proven lupus nephritis among patients with systemic lupus erythematosus Eight studies [14][15][16][17][18][19][20][21][22] reported the prevalence rate of BPLN among patients with SGD, corresponding to a total of 3,731 patients with LN among 5,979 patients with SGD in eight renal biopsy databases ( Table 2). The pooled rate of BPLN among patients with SGD was 60% (95% CI: 45-74%, I 2 = 99.3%, p<0.001) (Figure 2b).…”

“…These eight studies [14][15][16][17][18][19][20][21][22] were of patients from eight different countries: seven were conducted in Asia and Latin America, and one in Europe (Poland). The pooled rate of BPLN among patients with SGD in Asia and Latin America was 63% (95% CI: 48-79%, I 2 = 99.4%, p<0.001); this was significantly higher than the single rate of 34% (95% CI: 27-42%) in Poland, but not significantly different from the pooled rate of all eight countries, based on comparisons of 95% CIs (Figure 2b).…”

“…The sex distribution in patients with BPLN was reported by 11 studies, 11,[13][14][15]19,20,[22][23][24][25][26][27] with the percentage of females ranging from 51.4% to 92.5% (Tables 1, 2, and 3). The pooled prevalence of BPLN in female based on a randomeffects model was 85% (95% CI: 0.79 to 91%; I 2 = 81.37, p<0.001) (Figure 2c).…”