Global trends in incidence and mortality of nasopharyngeal carcinoma

Tang, Linlin; Chen, Wan Qing; Xue, Wen; He, Yong; Zheng, Rong; Zeng, Yi Xin; Jia, Wei Hua

doi:10.1016/j.canlet.2016.01.040

Cited by 341 publications

(283 citation statements)

References 33 publications

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“…Various studies have confirmed its association with NPC, 23,24 and its relationship with the high prevalence of NPC in Hong Kong and neighbouring regions in the 20th century. 6 N-nitrosamine found in the preserved salted fish is believed to be the carcinogen concerned. 25 Other factors such as the use of Chinese medicinal herbs and high consumption of fermented food were also suggested, but the associations were often inconsistent among studies.…”

Section: Environmental Factorsmentioning

confidence: 99%

“…4 The global data from GLOBOCAN in 2012 showed that 38% of all new cases of NPC were registered in China. 5 While Hong Kong is one of the regions that experience the most NPC, 6 it has also become a centre for NPC research. Indeed, many important and landmark studies in NPC were performed in Hong Kong, where local experts have been responsible for developing practice guidelines with regard to the diagnosis, management, and follow-up of NPC.…”

Section: Introductionmentioning

confidence: 99%

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Beating 'Guangdong cancer': a review and update on nasopharyngeal cancer

2017

Hong Kong Med J

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Section: Environmental Factorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Beating 'Guangdong cancer': a review and update on nasopharyngeal cancer

2017

Hong Kong Med J

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“…It has been reported that NPC distribution exhibits geographical characteristics, with presence mainly in Eastern and Southeastern Asia, and Northern Africa [2,3]. Epidemiological investigations have revealed that men are more susceptible to NPC than women [2]. The pathological causes of NPC are complex, and include Epstein Barr virus (EBV), smoking and hereditary factors [4].…”

Section: Introductionmentioning

confidence: 99%

“…The pathological causes of NPC are complex, and include Epstein Barr virus (EBV), smoking and hereditary factors [4]. In recent times, great progress has been made in the diagnosis and treatment of NPC, due to radiotherapy and chemotherapy [2,4]. However, NPC cells have become increasingly insensitive to radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Radio-sensitizing effect of ethyl caffeate on nasopharyngeal carcinoma CNE-2 cell line

Hai¹,

Han²,

Zhang³

2017

Trop. J. Pharm Res

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Purpose: To investigate the radio-sensitizing effect of ethyl caffeate (ETF) on naso-pharyngeal carcinoma. Methods: MTT (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) assay was used to evaluate the cell viability of CNE-2 cells, while their levels of caspase-3 and caspase-9 were determined by enzyme-linked immunosorbent assay (ELISA). In addition, a xenograft model was established in nude mice. The model was treated with ETF (40 mg/kg) and subjected to β-irradiation (10 Gy) for 28 days, during which tumor volume was determined at 4-day intervals. Expressions of caspase-3, caspase-9 and

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“…Although NPC is rare worldwide [3], this malignancy remains highly prevalent in endemic regions, notably in southern China [4]. Currently, radiotherapy remains the treatment of choice for NPC, and concomitant chemoradiotherapy has been proved to increase the survival [5,6].…”

Section: Introductionmentioning

confidence: 99%

Overexpression of β-Catenin Decreases the Radiosensitivity of Human Nasopharyngeal Carcinoma CNE-2 Cells

Kang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Nasopharyngeal carcinoma (NPC) is rare worldwide but remains highly prevalent in endemic regions, notably in southern China. Radiotherapy remains the treatment of choice for NPC, but radioresistance has been identified as a major cause of therapeutic failure. The Wnt/β-catenin signaling has been found to be involved in NPC radioresistance; however, the effect of β-catenin overexpression on radioresistance remains unknown in NPC until now. This study aimed to examine the impact of β-catenin overexpression on the radiosensitivity of human NPC CNE-2 cells. Methods: Immunohistochemistry was performed to detect the β-catenin expression in normal nasopharyngeal specimens and NPC specimens. The human NPC CNE-2 cell line overexpressing β-catenin was modeled by transfection with the pcDNA3.1/Hygro(+)/β-catenin recombinant vector (transfection group), while cells transfected with the pcDNA3.1/Hygro(+) vector served as negative controls and non-transfected cells served as blank controls. The expression of key molecules of the Wnt/β-catenin signaling pathway was determined using Western blotting and qPCR assays, and the changes of radiation sensitivity were measured with a colony-formation assay. Cell viability was measured by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5 -diphenyltetrazolium bromide) assay. In addition, the cell cycle and apoptosis was detected using flow cytometry and the TCF/LEF transcriptional activity was measured with a Dual Luciferase Reporter Assay System. Results: Immunohistochemical staining showed high β-catenin expression in radioresistant NPC specimens, and low expression in radiosensitive NPC specimens and normal nasopharyngeal specimens. Western blotting and qPCR assays detected higher β-catenin expression in the transfection group than in the negative and blank controls (P < 0.01). Down-regulation of GSK-3β expression (P < 0.05) and up-regulation of Cyclin D1 expression (P < 0.01) was detected in β-catenin overexpressing NPC cells exposed to X-ray radiation relative to negative and blank controls. Colony-formation assay revealed higher D₀, D_q and SF in the transfection group than in the negative and blank control groups post-radiation, and the SER in the transfection group was 0.75-fold and 0.68-fold greater than that in the blank and negative control groups, respectively. MTT assay revealed that the viability of CNE-2 cells was significantly higher in the transfection group (96% ± 8.72%) than in the negative control group (74.67 ± 7.05%) and the blank control group (75.33% ± 7.02%) 24 h post-exposure to 6 Gy X-ray radiation (P < 0.05). X-ray radiation led to a lower proportion of CNE-2 cells at the G2/M phase and a lower apoptotic rate in the transfection group than in the negative and blank control groups (P < 0.05). In addition, the TCF/LEF transcriptional activity was higher in the transfection group than in the negative and blank control groups (P < 0.01), and 6 Gy X-ray radiation elevated the TCF/LEF transcriptional activity relative to 0 Gy radiation ...

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Global trends in incidence and mortality of nasopharyngeal carcinoma

Cited by 341 publications

References 33 publications

Beating 'Guangdong cancer': a review and update on nasopharyngeal cancer

Beating 'Guangdong cancer': a review and update on nasopharyngeal cancer

Radio-sensitizing effect of ethyl caffeate on nasopharyngeal carcinoma CNE-2 cell line

Overexpression of β-Catenin Decreases the Radiosensitivity of Human Nasopharyngeal Carcinoma CNE-2 Cells

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