Cell Reports volume 5, issue 2, P357-366 2013 DOI: 10.1016/j.celrep.2013.09.016 View full text
Sho Ohta, Eisuke Nishida, Shinya Yamanaka, Takuya Yamamoto

Abstract: Alternative splicing generates multiple transcripts from a single gene, and cell-type-specific splicing profiles are important for the properties and functions of the cells. Recently, somatic cells have been shown to undergo dedifferentiation after the forced expression of transcription factors. However, it remains unclear whether somatic cell splicing is reorganized during reprogramming. Here, by combining deep sequencing with high-throughput absolute qRT-PCR, we show that somatic splicing profiles revert to …

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