Global patterns and trends in incidence and mortality of thyroid cancer in children and adolescents: a population-based study

Vaccarella, Salvatore; Lortet‐Tieulent, Joannie; Colombet, Murielle; Davies, Louise; Stiller, Charles; Schüz, Joachim; Togawa, Kayo; Bray, Freddie; Franceschi, Silvia; Maso, Luigino Dal; Steliarova‐Foucher, Eva; contributors, Iicc

doi:10.1016/s2213-8587(20)30401-0

Cited by 105 publications

(103 citation statements)

References 39 publications

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…In the analysis of distribution of incidence (Figure1), we found that the trends reported for overall incidence were largely driven by "15-19 years" group, "Female" group, "White" group, "Localized" group, "Regional" group and DTC types (papillary TC, 87%). Physiologically, this can be explained by differences in developmental status, hormone levels and race [16,17]. However, we observed that the annual increase rates of distant TC are lower than those observed for localized or regionally, which contradicted the ndings of a previous study [2].…”

Section: Discussioncontrasting

confidence: 95%

“…The signi cant annual increases in the rates of small size tumor (<4cm) and local stage TC in children suggests that we might not be able to rule out a contribution of over detection to rising pediatric DTC rates. A global study [17] shows that there is over-diagnosis among childhood TC, too. Because patients undergoing detection are younger and healthier and are diagnosed with lower-risk TC, they are less likely to die [18].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Incidence and Prognosis of Thyroid Cancer in Children: Based on the SEER Database

Zhang¹,

Wu²,

Shang³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Studying the incidence trend and prognosis factors of childhood Thyroid cancer (TC) may better reflect the prevalence of this disease. Objectives: To explore the trends in the incidence of childhood thyroid cancer and the prognosis.Material and Methods: Join-point regression model was used to analyze incidence trend of TC. Cox regression model was applied to explore the survival situation and prognostic factors.Results: The incidence rate of childhood TC increased between 1975 and 2016 from 3.8/million (95%CI: 2.6-5.5) to 11.5/million (95%CI: 9.2-14.1), AAPC = 2.38 (95%CI: 1.98-9.65)) and could be divided into two stages of increasing trends. The incidence rate of Trend1 (1975-2005) increased slowly but Trend2 (2005-2016) increased dramatically. And annual rates of small size tumor (<4cm) and local stage TC in children increased significantly. The overall cumulative survival rate for childhood TC was high up to 97%-99%. Males, the black people, MTC type, distant metastasis, tumor size >= 4 cm, non-primary cancer were the independent risk factors of prognosis of childhood TC.Conclusions and Significance: A contribution of over detection to rising pediatric TC rates might not be able to rule out. Over-treatment to small size and local stage TC in children should be avoided.

show abstract

Section: Discussioncontrasting

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Incidence and Prognosis of Thyroid Cancer in Children: Based on the SEER Database

Zhang¹,

Wu²,

Shang³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Differentiated thyroid cancer (DTC) is the most common paediatric endocrine cancer and accounts for 3% of all paediatric cases of malignant neoplasms 1‐4 . Although disease‐specific survival rate exceeds 99% at 30 years in paediatric DTC, 4,5 cancer recurrence and persistence remain a concern for paediatric patients, their parents and physicians. The literature on paediatric DTC indicates an incidence of recurrent and persistent diseases ranging from 11% to 42% 6‐14 .…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of lymph node ratio in children and adolescents with papillary thyroid cancer

Wang

Zhang

et al. 2021

Clinical Endocrinology

View full text Add to dashboard Cite

Objective Neck lymph node (LN) metastasis is a common feature of paediatric papillary thyroid cancer, and LN ratio (LNR) is defined as the ratio of the number of positive LNs excised to the total number of removed. Unlike in adults, few data are available regarding the clinical implication of LNR in the paediatric population. Our purpose was to investigate the association of LNR with clinical outcomes in paediatric papillary thyroid cancer. Design & Methods The study retrospectively reviewed 136 consecutive children and adolescents with papillary thyroid cancer and LN involvement but no initial distant metastasis. Initial treatment, included in all patients a total thyroidectomy with central and/or lateral neck dissection followed by radioactive iodine ablation. Within the neck dissections, total number of LNs removed, total positive LNs and LN ratios were determined. The effect of clinicopathologic characteristics and intraoperative findings on persistent and recurrent diseases were analysed by univariate and multivariate analyses. Results Median number of positive LNs was 9, and median LNR was 0.4. During a median follow‐up of 49 months (range, 12.0‐139 months), persistent disease occurred in 43 (31.6%) patients. The multivariable analysis showed that age and LNR were the independent factors predictive of persistent disease. Patients with a LNR >0.34 exhibited a threefold higher risk of persistent disease after initial therapy than the counterparts (P = .02). Conclusion Our findings suggest that LNR was an independent determinant predictive of persistent disease after initial therapy in children and adolescents with papillary thyroid cancer.

show abstract

“…In 2020, liver cancer ranks the fifth in cancer incidence and the third in tumor related mortality worldwide (21). Sorafenib is the first target drug approved for the treatment of hepatocellular carcinoma (HCC), a major type of liver cancer, which can prolong the overall survival time with a response rate of only 2% (22,23).…”

Section: Introductionmentioning

confidence: 99%

Integrative Pan-Cancer Analysis Reveals Decreased Melatonergic Gene Expression in Carcinogenesis and RORA as a Prognostic Marker for Hepatocellular Carcinoma

et al. 2021

View full text Add to dashboard Cite

BackgroundMelatonin has been shown to play a protective role in the development and progression of cancer. However, the relationship between alterations in the melatonergic microenvironment and cancer development has remained unclear.MethodsWe performed a comprehensive investigation on 12 melatonergic genes and their relevance to cancer occurrence, progression and survival by integrating multi-omics data from microarray analysis and RNA sequencing across 11 cancer types. Specifically, the 12 melatonergic genes that we investigated, which reflect the melatonergic microenvironment, included three membrane receptor genes, three nuclear receptor genes, two intracellular receptor genes, one synthetic gene, and three metabolic genes.ResultsWidely coherent underexpression of nuclear receptor genes, intracellular receptor genes, and metabolic genes was observed in cancerous samples from multiple cancer types compared to that in normal samples. Furthermore, genomic and/or epigenetic alterations partially contributed to these abnormal expression patterns in cancerous samples. Moreover, the majority of melatonergic genes had significant prognostic effects in predicting overall survival. Nevertheless, few corresponding alterations in expression were observed during cancer progression, and alterations in expression patterns varied greatly across cancer types. However, the association of melatonergic genes with one specific cancer type, hepatocellular carcinoma, identified RORA as a tumor suppressor and a prognostic marker for patients with hepatocellular carcinoma.ConclusionsOverall, our study revealed decreased melatonergic gene expression in various cancers, which may help to better elucidate the relationship between melatonin and cancer development. Taken together, our findings highlight the potential prognostic significance of melatonergic genes in various cancers.

show abstract

Global patterns and trends in incidence and mortality of thyroid cancer in children and adolescents: a population-based study

Cited by 105 publications

References 39 publications

Incidence and Prognosis of Thyroid Cancer in Children: Based on the SEER Database

Incidence and Prognosis of Thyroid Cancer in Children: Based on the SEER Database

Prognostic value of lymph node ratio in children and adolescents with papillary thyroid cancer

Integrative Pan-Cancer Analysis Reveals Decreased Melatonergic Gene Expression in Carcinogenesis and RORA as a Prognostic Marker for Hepatocellular Carcinoma

Contact Info

Product

Resources

About