Global Lung Initiative 2012 spirometry reference values in a large Asian cohort of Malay, Chinese and Indian ancestry

Abdullah, Nor Azizan; Borhanuddin, Boekhtiar; Shah, Shamsul Azhar; Hassan, Tidi; Jamal, Rahman

doi:10.1111/resp.13330

Cited by 19 publications

(27 citation statements)

References 24 publications

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“…Studies validating the GLI 2012 SRE have made varying conclusions, with some indicating a poor fit for local populations [10,15]. However, the FEV 1 /FVC ratio has consistently demonstrated a better fit across populations than other lung function measurements [10,[15][16][17]. Potential reasons for poor fit of SRE include sampling which is unrepresentative of the population, potential mis-specification of the prediction equations, and environmental factors such as exposure to indoor and/or ambient air pollution, malnutrition, and low socioeconomic status (SES), which may result in lower lung volumes on a population level, leading to erroneous estimations [18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Validation of the global lung initiative 2012 multi-ethnic spirometric reference equations in healthy urban Zimbabwean 7–13 year-old school children: a cross-sectional observational study

et al. 2020

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Background: The 2012 Global Lung Function Initiative (GLI 2012) provide multi-ethnic spirometric reference equations (SRE) for the 3-95 year-old age range, but Sub-Saharan African populations are not represented. This study aimed to evaluate the fit of the African-American GLI 2012 SRE to a population of healthy urban and peri-urban Zimbabwean school-going children (7-13 years). Methods: Spirometry and anthropometry were performed on black-Zimbabwean children recruited from three primary schools in urban and peri-urban Harare, with informed consent and assent. Individuals with a history or current symptoms of respiratory disease or with a body mass index-z score (BMI) < − 2 were excluded. Spirometry z-scores were generated from African-American GLI 2012 SRE, which adjust for age, sex, ethnicity and height, after considering all GLI 2012 modules. Anthropometry z-scores were generated using the British (1990) reference equations which adjust for age and sex. The African-American GLI 2012 z-score distribution for the four spirometry measurements (FVC, FEV 1 , FEV 1 / FVC and MMEF) were evaluated across age, height, BMI and school (as a proxy for socioeconomic status) to assess for bias. Comparisons between the African-American GLI 2012 SRE and Polgar equations (currently adopted in Zimbabwe) on the percent-predicted derived values were also performed. Results: The validation dataset contained acceptable spirometry data from 712 children (344 girls, mean age: 10.5 years (SD 1.81)). The spirometry z-scores were reasonably normally distributed, with all means lower than zero but within the range of ±0.5, indicating a good fit to the African-American GLI 2012 SRE. The African-American GLI 2012 SRE produced z-scores closest to a normal distribution. Z-scores of girls deviated more than boys. Weak correlations (Pearson's correlation coefficient < 0.2) were observed between spirometry and anthropometry z-scores, and scatterplots demonstrated no systematic bias associated with age, height, BMI or socioeconomic status. The African-American GLI 2012 SRE provided a better fit for Zimbabwean paediatric spirometry data than Polgar equations. Conclusion: The use of African-American GLI 2012 SRE in this population could help in the interpretation of pulmonary function tests.

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Section: Introductionmentioning

confidence: 99%

Validation of the global lung initiative 2012 multi-ethnic spirometric reference equations in healthy urban Zimbabwean 7–13 year-old school children: a cross-sectional observational study

et al. 2020

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“…The work of Abdullah et al ., recently published in Respirology , accepted the call from the GLI network to assess the broader global generalizability of the GLI spirometry equations . The authors obtained spirometry in over 30 000 healthy adults (aged 35–70 years) of Malay, Chinese and Indian ancestries and compared their data with that of the GLI Other equation.…”

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confidence: 60%

“…To date, many of the studies that have assessed the validity of the GLI equations have confirmed that FEV 1 /FVC is independent of ethnicity with a very close match to the GLI equations. This did not occur in the study by Abdullah et al ., in which the mean FEV 1 /FVC z‐scores ranged between 1.1 and 1.6 across the three ethnic groups assessed. These differences are not easily explained and may be influenced by unknown methodological factors or may represent true differences of the proportional distribution of flows and volumes in spirometry outcomes.…”

mentioning

confidence: 99%

“…6 The work of Abdullah et al, recently published in Respirology, accepted the call from the GLI network to assess the broader global generalizability of the GLI spirometry equations. 7 The authors obtained spirometry in over 30 000 healthy adults (aged 35-70 years) of Malay, Chinese and Indian ancestries and compared their data with that of the GLI Other equation. This study reports significant and clinically relevant differences in forced expiratory volume in 1 s (FEV 1 ), forced vital capacity (FVC) and FEV 1 /FVC in all ethnic subgroups, with mean lung function being as low as −2.8 z-scores below predicted.…”

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confidence: 99%

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Increasing diversity within the Global Lung Function Initiative

Hall

Cooper

2018

Respirology

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“…The records for 50 consecutive admissions with acute exacerbation of COPD were reviewed. The inclusion criteria included a definite history of smoking and a diagnosis of COPD based on spirometric evidence of obstruction according to European Respiratory Society criteria [8]. Exclusion criteria included a clinical diagnosis only for COPD, without any spirometric evidence, and admission to the ICU for any cause other than acute exacerbation of COPD, such as pneumonia.…”

Section: Methodsmentioning

confidence: 99%

Factors Predicting Treatment Outcome in Hospitalized Patients with Acute Exacerbation of COPD (AECOPD)

Uppe¹

2018

AJIM

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Objective: The aim of our study was to study the COPD phenotypes, comorbidities and factors predicting treatment outcomes in patients with acute exacerbations of COPD admitted in hospital. Methodology: A retrospective study of fifty patients with acute exacerbation of COPD admitted in a tertiary care hospital during July 2015 to August 2016 was done. Results: It was observed that the mean duration of hospital stay was 8 ± 7 days with 44% of the patient discharged in less than 7 days (short stay) and 56% of patients in more than 7 days (long stay). The factors favouring longer stay in hospital include history of current smoking, hypoxia and CO 2 retention while patients on active COPD treatment and cessation of smoking leads to shorter hospital stay. Conclusion: For patients with acute exacerbations of COPD requiring hospitalization, history of current smoking with hypoxia and CO 2 retention are associated with longer stay in hospital while patients on active COPD treatment and cessation of smoking leads to shorter hospital stay.

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Global Lung Initiative 2012 spirometry reference values in a large Asian cohort of Malay, Chinese and Indian ancestry

Abstract: This present and large multi-ethnic Asian-based study demonstrates clinically significant deviation from ERS/GLI 2012 equations for spirometry. It highlights the importance of validating predicted equations for spirometry in local populations.

Cited by 19 publications

References 24 publications

Validation of the global lung initiative 2012 multi-ethnic spirometric reference equations in healthy urban Zimbabwean 7–13 year-old school children: a cross-sectional observational study

Validation of the global lung initiative 2012 multi-ethnic spirometric reference equations in healthy urban Zimbabwean 7–13 year-old school children: a cross-sectional observational study

Increasing diversity within the Global Lung Function Initiative

Factors Predicting Treatment Outcome in Hospitalized Patients with Acute Exacerbation of COPD (AECOPD)

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