Global health-related quality of life in schizophrenia: systematic review and meta-analysis

Abstract

Background and aimSigns and symptoms of schizophrenia may have serious impacts on patients’ quality of life leading to concern about different aspects of their lives. This study presents a systematic review and meta-analysis of the studies examining the quality of life among patients with schizophrenia and its relationship with patients’ characteristics.Materials and methodsA total of 40 studies were extracted from searching of relevant databases published between 2000 and 2020. Descriptive data and correlation coefficients between patient’s characteristics and quality of life were extracted and the results were reported according to Preferred Reporting Items for Systematic Reviews and Meta-analyses standards and meta-analysis of pooled studies.ResultsIn total, 8363 patients with schizophrenia participated in 40 studies which used Schizophrenia Quality of Life Scale revision 4. The total score of quality of life (QOL) in the study subjects was reported to be 40.66. Weighted effect size analyses revealed a significant relationship between QOL and variables including patients’ age and duration of the disease. Furthermore, the highest (the worst) score of QOL in schizophrenia patients was observed in Europe 47.04 (95% CI 41.26 to 52.82) and the Euro region 47.05 (95% CI 41.18 to 52.92).ConclusionOverall, the QOL among patients with schizophrenia was in a good status, which could be improved through considering different life aspects of people living in various contexts. In fact, clarifying the determinants of QOL would be a key step in the provision of future treatment efforts.

The relationship between psychopathology, occupational balance, and quality of life among people with schizophrenia

“…Previous studies reported that individuals with severe mental disorders had difficulties participating in basic daily living tasks because of more preoccupation with the symptoms of illness, and severe psychiatric symptoms contribute to the decrease in QoL (De Pinho et al, 2018; Doroud et al, 2015; Hoseinipalangi et al, 2022). Therefore, disease symptoms are among the most important determinants that impair the QoL of people with schizophrenia, as stated in the literature.…”

“…Research evidence suggests that the QoL of individuals with mental illness was lower than that of physically ill or healthy individuals (Berghöfer et al, 2020; Ginieri‐Coccossis et al, 2009). It has been reported in the literature that many factors such as social and economic difficulties, severe psychiatric symptoms, duration of mental illness, non‐adherence to treatment, frequent hospitalisations, lack of social support, unemployment and stigma contribute to the decrease in QoL in people with schizophrenia (De Pinho et al, 2018; Desalegn et al, 2020; Hoseinipalangi et al, 2022; Rocca et al, 2016). In addition, recent studies have shown the relationship between symptoms of the disease (negative and positive symptoms) and poor QoL as well as general psychopathology (e.g.…”

Correlation of health literacy, health management self‐efficacy, and attitude in elderly patients with schizophrenia: A cross‐sectional study

“…These studies suggest that schizophrenia can have a negative impact on the physical health and functioning of older patients, which in turn affects their quality of life. (Dong et al, 2019;Hoseinipalangi et al, 2022;Solomon et al, 2021). Therefore, focusing on patients' physiological functions, early detection of health problems, and physical health maintenance is imperative.…”