volume 8, issue 9, P2232-2252 2016
DOI: 10.18632/aging.101056
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Abstract: ObjectiveRecent studies implicate cardiolipin oxidation in several age-related diseases. Atp8b1 encoding Type 4 P-type ATPases is a cardiolipin transporter. Mutation in Atp8b1 gene or inflammation of the lungs impairs the capacity of Atp8b1 to clear cardiolipin from lung fluid. However, the link between Atp8b1 mutation and age-related gene alteration is unknown. Therefore, we investigated how Atp8b1 mutation alters age-related genes.MethodsWe performed Affymetrix gene profiling of lungs isolated from young (7-…

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