Global Ethanol-Induced Enhancements of Monoaminergic Neurotransmission: A Meta-Analysis Study

Brand, Ines; Fliegel, Sarah; Spanagel, Rainer; Noori, Hamid

doi:10.1111/acer.12207

Cited by 31 publications

(32 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The range of concentrations observed in our SR seems to be larger than the range described in, for example, a narrative review of acetylcholine (Pepeu and Giovannini ) and a SR of noradrenaline, serotonin and dopamine (Brand et al . ), both restricted to a subset of studies with more comparable experimental designs. Most reviews on microdialysis do not describe baseline levels.…”

Section: Discussionmentioning

confidence: 99%

Intracerebral microdialysis of adenosine and adenosine monophosphate – a systematic review and meta‐regression analysis of baseline concentrations

Mierden

Savelyev²,

IntHout

et al. 2018

Journal of Neurochemistry

View full text Add to dashboard Cite

Microdialysis is a method to study the extracellular space in vivo, based on the principle of diffusion. It can be used to measure various small molecules including the neuroregulator adenosine. Baseline levels of the compounds measured with microdialysis vary over studies. We systematically reviewed the literature to investigate the full range of reported baseline concentrations of adenosine and adenosine monophosphate in microdialysates. We performed a meta‐regression analysis to study the influence of flow rate, probe membrane surface area, species, brain area and anaesthesia versus freely behaving, on the adenosine concentration. Baseline adenosine concentrations in microdialysates ranged from 0.8 to 2100 nM. There was limited evidence on baseline adenosine monophosphate concentrations in microdialysates. Across studies, we found effects of flow rate and anaesthesia versus freely behaving on dialysate adenosine concentrations (p ≤ 0.001), but not of probe membrane surface, species, or brain area (p ≥ 0.14). With increasing flow rate, adenosine concentrations decreased. With anaesthesia, adenosine concentrations increased. The effect of other predictor variables on baseline adenosine concentrations, for example, post‐surgical recovery time, could not be analysed because of a lack of reported data. This study shows that meta‐regression can be used as an alternative to new animal experiments to answer research questions in the field of neurochemistry. However, current levels of reporting of primary studies are insufficient to reach the full potential of this approach; 63 out of 133 studies could not be included in the analysis because of insufficient reporting, and several potentially relevant factors had to be excluded from the analyses. The level of reporting of experimental detail needs to improve.

show abstract

Section: Discussionmentioning

confidence: 99%

Intracerebral microdialysis of adenosine and adenosine monophosphate – a systematic review and meta‐regression analysis of baseline concentrations

Mierden

Savelyev²,

IntHout

et al. 2018

Journal of Neurochemistry

View full text Add to dashboard Cite

show abstract

“…We thus hope to inspire chronobiologists to use more systematised review strategies. We highly encourage anyone performing a meta-analysis on microdialysis data to address the effects of variations in experimental design, as done, for example, in [205152]. …”

Section: Discussionmentioning

confidence: 99%

A Systematic Search and Mapping Review of Studies on Intracerebral Microdialysis of Amino Acids, and Systematized Review of Studies on Circadian Rhythms

Leenaars

Freymann

Jakobs

et al. 2018

J Circadian Rhythms

View full text Add to dashboard Cite

Background:Microdialysis can be used to measure amino acids in the extracellular space in vivo, based on the principle of diffusion. Variations in experimental set-up result in variations in baseline levels of the compounds measured. Variations may also be due to circadian rhythms.Method:We systematically searched and mapped the literature on all studies reporting baseline microdialysis measurements of histamine and the amino acids asparagine, aspartate, GABA, glutamate, glutamine, glycine, proline and taurine. We fully reviewed the studies describing circadian rhythms for histamine and the selected amino acids.Results:We retrieved 2331 papers describing baseline measurements of one or more of the compounds of interest. We provide a numerical summary and lists of the publications by compound. We retrieved 11 references describing studies on the circadian rhythms of the compounds of interest. Aspartate, glutamate and histamine are generally higher during the dark than during the light phase in nocturnal rodents. For glutamine, no rhythmicity was observed. For GABA, the results were too inconsistent to generalise. For asparagine, glycine, proline and taurine, insufficient data are available.Conclusion:The literature on intracerebral microdialysis measurements of the amino acids is vast, but certain primary studies are still warranted. Future systematic reviews on the individual compounds can shed light on the effects of experimental variations on baseline concentrations.

show abstract

“…A previously reported (Noori, et al, 2012a; Brand, et al, ; Fliegel, et al, ; Hirth, et al, ; Fritze, et al, ; Noori, et al, ), we have established a robust pipeline for standardized data mining, database creation and integrative analysis of pre‐clinical neuropsychopharmacology experiments. This approach allows accurate extraction of maximum amount of data with a minimized chance for missing critical information and was therefore applied here to characterize basal dopamine concentrations as well as overlapping and distinct features of striatal dopaminergic response to systemically administered drugs of abuse in female rats.…”

Section: Methodsmentioning

confidence: 99%

“…A previously reported (Noori, et al, 2012a; Brand, et al, ; Fliegel, et al, ; Hirth, et al, ; Fritze, et al, ; Noori, et al, ), three categories (i.e. biological, experimental procedure and outcome) of study variables and parameters were extracted using a structured template.…”

Section: Methodsmentioning

confidence: 99%

No basal or drug‐induced sex differences in striatal dopaminergic levels: a cluster and meta‐analysis of rat microdialysis studies

Egenrieder

Mitricheva

Spanagel

et al. 2019

Journal of Neurochemistry

Self Cite

View full text Add to dashboard Cite

Sex differences in behavioural patterns of drug abuse and dependence have been hypothesized to be a consequence of sexual dimorphisms in brain pathways, particularly within the dopaminergic reward circuitry. Yet, how potential sex differences are manifested at a neurochemical level remains unclear. Here, we use a meta‐analysis approach to investigate whether animal studies robustly indicate a different regulation of striatal dopamine transmission in males and females. Data from 39 microdialysis experiments on female rats (n = 676) were extracted and statistically compared with data from 1523 male rats. All drugs of abuse, independent of their molecular mechanisms of action, notably increase extracellular dopamine concentrations in the nucleus accumbens (NAc) and caudate putamen (CPu). No significant sex differences in basal levels or in dopaminergic response to drugs of abuse were found. However, basal dopamine levels in CPu (but not NAc) were significantly altered by ovariectomy. In conclusion, there are no sex‐dependent differences in basal dopamine levels within the NAc and CPu. Previously reported sex differences in the CPu seem to be a result of ovariectomy and may only to a lesser, non‐significant degree be attributed to a sexual duality.

show abstract

Global Ethanol-Induced Enhancements of Monoaminergic Neurotransmission: A Meta-Analysis Study

Abstract: Our results provide a universal database and framework for the optimal design of future in vivo microdialysis and in silico experiments in neurochemistry and pharmacology.

Cited by 31 publications

References 38 publications

Intracerebral microdialysis of adenosine and adenosine monophosphate – a systematic review and meta‐regression analysis of baseline concentrations

Intracerebral microdialysis of adenosine and adenosine monophosphate – a systematic review and meta‐regression analysis of baseline concentrations

A Systematic Search and Mapping Review of Studies on Intracerebral Microdialysis of Amino Acids, and Systematized Review of Studies on Circadian Rhythms

No basal or drug‐induced sex differences in striatal dopaminergic levels: a cluster and meta‐analysis of rat microdialysis studies

Contact Info

Product

Resources

About