Global distribution of peste des petits ruminants virus and prospects for improved diagnosis and control

Banyard, Ashley C.; Parida, Satya; Batten, Carrie; Oura, C.A.L.; Kwiatek, Olivier; Libeau, Geneviève

doi:10.1099/vir.0.025841-0

Cited by 377 publications

(453 citation statements)

References 80 publications

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“…PPR is caused by peste des petits ruminants virus (PPRV), a highly contagious virus that gives rise to disease in sheep, goats, and camels and has also been reported in wild ruminants [6]. Clinical signs of PPR include pyrexia (40–41°C), ocular and nasal discharges, lesions in the oral and nasal mucus membranes, dyspnoea, cough, pneumonia, diarrhoea, and severe dehydration [7].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence and risk factors for peste des petits ruminants and selected differential diagnosis in sheep and goats in Tanzania

Torsson

Berg

Misinzo

et al. 2017

Infection Ecology & Epidemiology

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Introduction: Livestock husbandry is critical for food security and poverty reduction in a low-income country like Tanzania. Infectious disease is one of the major constraints reducing the productivity in this sector. Peste des petits ruminants (PPR) is one of the most important diseases affecting small ruminants, but other infectious diseases may also be present. Objective: The objective of this study was to determine the seroprevalence and risk factors for exposure to PPR, contagious caprine pleuropneumonia (CCPP), foot-and-mouth disease (FMD), bluetongue (BT), and bovine viral diarrhoea (BVD) in sheep and goats in Tanzania. Methods: Serum samples were collected in 2014 and 2015, and analysed using enzyme-linked immunosorbent assays to detect antibodies to the five pathogens. Results and discussion: This is the first description of seroprevalence of FMD and BT among small ruminants in Tanzania. Risk factor analysis identified sex (female) (OR for 2014: PPR: 2.49, CCPP: 3.11, FMD: 2.98, BT: 12.4, OR for 2015: PPR: 14.1, CCPP: 1.10, FMD: 2.67, BT: 1.90, BVD: 4.73) and increasing age (>2 years) (OR for 2014: PPR: 14.9, CCPP: 2.34, FMD: 7.52, BT: 126, OR for 2015: PPR: 8.13, CCPP: 1.11, FMD: 2.98, BT: 7.83, BVD: 4.74) as risk factors for exposure to these diseases.

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Section: Introductionmentioning

confidence: 99%

Seroprevalence and risk factors for peste des petits ruminants and selected differential diagnosis in sheep and goats in Tanzania

Torsson

Berg

Misinzo

et al. 2017

Infection Ecology & Epidemiology

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“…PPRV virology has been extensively reviewed elsewhere [2,3,11,12]; however, the salient points are that this virus is a highly infectious pathogen causing an acute febrile illness within susceptible sheep and goat populations. The associated disease has high morbidity, with mortality rates approaching 50 to 80 % [1]. There is no known arthropod vector, and transmission is thought to be via aerosol or contaminated fomites [12].…”

Section: Pprvmentioning

confidence: 99%

“…Peste des petits ruminants (PPR) represents one of the most important challenges to sustainable small-scale agriculture, particularly sheep and goat farming, in the developing world [1]. High mortality epidemics of PPR, combined with longterm endemicity, threaten the livelihoods of subsistence farmers and undermine the fragile economies that this industry supports [2,3].…”

Section: Introductionmentioning

confidence: 99%

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication

Baron

Diop

Njeumi

et al. 2017

Journal of General Virology

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Peste des petits ruminants virus (PPRV) is a significant pathogen of small ruminants and is prevalent in much of Africa, the Near and Middle East and Asia. Despite the availability of an efficacious and cheap live-attenuated vaccine, the virus has continued to spread, with its range stretching from Morocco in the west to China and Mongolia in the east. Some of the world's poorest communities rely on small ruminant farming for subsistence and the continued endemicity of PPRV is a constant threat to their livelihoods. Moreover, PPRV's effects on the world's population are felt broadly across many economic, agricultural and social situations. This far-reaching impact has prompted the Food and Agriculture Organization of the United Nations (FAO) and the World Organisation for Animal Health (OIE) to develop a global strategy for the eradication of this virus and its disease. PPRV is a morbillivirus and, given the experience of these organizations in eradicating the related rinderpest virus, the eradication of PPRV should be feasible. However, there are many critical areas where basic and applied virological research concerning PPRV is lacking. The purpose of this review is to highlight areas where new research could be performed in order to guide and facilitate the eradication programme. These areas include studies on disease transmission and epidemiology, the existence of wildlife reservoirs and the development of next-generation vaccines and diagnostics. With the support of the international virology community, the successful eradication of PPRV can be achieved.

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“…This transboundary nature of the disease is one of the main constraints in augmenting the productivity of small ruminants in enzootic regions including the parts of Africa, the Middle East and the parts of Asia. Recent developments in the diagnosis of PPR, prospects for improved diagnosis and vaccine development for disease control have been reviewed earlier [17,43,45,125]. However, the present review article comprehend the current scenario of PPR diagnosis and control with advancement of research areas that have taken place in the recent years particularly on diagnostic approaches and control measures with economic impact and future perspectives.…”

Section: Introductionmentioning

confidence: 99%

“…PPR was first reported in the Ivory Coast, West Africa [56], and later from other parts of the world namely sub-Saharan Africa, the Middle East and Indian subcontinent [128,130]. Spread of disease to a number of new countries in Africa and Asia with involvement of various lineage of PPRV is a cause of global concern especially recent introduction of Asian lineage in some African countries and presence of PPR in Europe through Western Turkey [1,17,77,102]. This transboundary nature of the disease is one of the main constraints in augmenting the productivity of small ruminants in enzootic regions including the parts of Africa, the Middle East and the parts of Asia.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis and control of peste des petits ruminants: a comprehensive review

Balamurugan¹,

Hemadri²,

Gajendragad³

et al. 2013

VirusDis.

130

118

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Peste des petits ruminants (PPR) is an acute, highly contagious, world organization for animal health (OIE) notifiable and economically important transboundary viral disease of sheep and goats associated with high morbidity and mortality and caused by PPR virus. PPR is considered as one of the main constraints in augmenting the productivity of small ruminants in developing countries and particularly severely affects poor farmer's economy. The disease is clinically manifested by pyrexia, oculo-nasal discharges, necrotizing and erosive stomatitis, gastroenteritis, diarrhoea and bronchopneumonia. The disease can be diagnosed from its clinical signs, pathological lesions, and specific detection of virus antigen/antibodies/genome in the clinical samples by various serological tests and molecular assays. PPR is the one of the priority animal diseases whose control is considered important for poverty alleviation in enzootic countries. Availability of effective and safe live attenuated cell culture PPR vaccines and diagnostics have boosted the recently launched centrally sponsored control programme in India and also in other countries. This review article primarily focus on the current scenario of PPR diagnosis and its control programme with advancement of research areas that have taken place in the recent years with future perspectives.

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Global distribution of peste des petits ruminants virus and prospects for improved diagnosis and control

Cited by 377 publications

References 80 publications

Seroprevalence and risk factors for peste des petits ruminants and selected differential diagnosis in sheep and goats in Tanzania

Seroprevalence and risk factors for peste des petits ruminants and selected differential diagnosis in sheep and goats in Tanzania

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication

Diagnosis and control of peste des petits ruminants: a comprehensive review

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