Global distribution of animal sporotrichosis: A systematic review of Sporothrix sp. identified using molecular tools

Morgado, Débora Salgado; Castro, Rodolfo; Ribeiro-Alves, Marcelo; Corrêa‐Moreira, Danielly; Castro-Alves, Júlio; Pereira, Sandro Antônio; Menezes, Rodrigo Caldas; Oliveira, Manoel Marques Evangelista

doi:10.1016/j.crmicr.2022.100140

Cited by 9 publications

(12 citation statements)

References 35 publications

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“…Furthermore, the Rosmarinus extract was able to inhibit both Candida strains, further showing its antifungal action [ 74 ]. Sporotrichosis is a subcutaneous fungal infection caused by fungi of the genus Sporothrix , increasingly affecting humans and cats [ 75 ]. Despite the limited experimental data on the effects of rosemary essential oil on the treatment of sporotrichosis, studies in the current literature confirm its antifungal activity against Sporothrix schenckii [ 76 ] and itraconazole-resistant Sporothrix brasiliensis [ 76 , 77 ].…”

Section: Resultsmentioning

confidence: 99%

Rosmarinus officinalis and Skin: Antioxidant Activity and Possible Therapeutical Role in Cutaneous Diseases

et al. 2023

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The rosemary plant, Rosmarinus officinalis L., one of the main members of the Lamiaceae family, is currently one of the most promising herbal medicines due to its pharmaceutical properties. This research aimed to evaluate the antioxidant role of Rosmarinus officinalis and its bioactive compounds on the skin, with a focus on the newly emerging molecular mechanisms involved, providing extensive scientific evidence of its anti-inflammatory, antimicrobial, wound-healing and anticancer activity in dermatological practice. The search was conducted on articles concerning in vitro and in vivo studies in both animals and humans. The results obtained confirm the antioxidant role of R. officinalis. This assumption derives the possibility of using R. officinalis or its bioactive elements for the treatment of inflammatory and infectious skin pathologies. However, although the use of rosemary in the treatment of skin diseases represents a fascinating line of research, future perspectives still require large and controlled clinical trials in order to definitively elucidate the real impact of this plant and its components in clinical practice.

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Section: Resultsmentioning

confidence: 99%

Rosmarinus officinalis and Skin: Antioxidant Activity and Possible Therapeutical Role in Cutaneous Diseases

et al. 2023

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“…Currently, the phenotypic characteristic alone is not sufficient to identify species of the genus Sporothrix spp., due to the uncertainty of the tests involved. Thus, the use of molecular methodologies is required [ 37 , 46 , 55 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 83 , 84 ]; among them, the sequencing of the ITS region of the rDNA is one of the most used [ 19 , 72 ].…”

Section: Discussionmentioning

confidence: 99%

“…A recently published study by Morgado et al [ 46 ] mentions that South America is the continent with the highest animal sporotrichosis prevalence (81%), followed by Asia and Europe [ 47 ], while North America and Africa report the same proportion. In South America, most of the isolates are concentrated in Brazil [ 48 ] and then in Argentina [ 38 ] and occur mainly in cats, followed by dogs [ 49 , 50 , 51 ].…”

Section: Introductionmentioning

confidence: 99%

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Sporotrichosis Outbreak Due to Sporothrix brasiliensis in Domestic Cats in Magallanes, Chile: A One-Health-Approach Study

Thomson

González

Blank³

et al. 2023

JoF

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Sporotrichosis is an implantation mycosis with subcutaneo-lymphatic or, more rarely, a viscerally disseminated affection; it can be acquired through traumatic percutaneous inoculation of the fungus present in soil or plant matter, or by feline scratching. Among the causative agents, Sporothrix brasiliensis is considered the most virulent species with a high prevalence in Brazil and recently in Argentina. Objective: Describe a S. brasiliensis outbreak in domestic and feral cats detected in the Magallanes region of southern Chile. Materials and Methods: Between the months of July and September 2022, three cats presented with suppurative subcutaneous lesions located mainly on the head and thoracic limbs. The cytology revealed the presence of yeasts with morphological characteristics suggestive of Sporothrix spp. The histopathology confirmed pyogranulomatous subcutaneous lesions associated with the presence of the same yeasts. The fungal culture followed by the partial gene sequence and analysis of the ITS region confirmed the diagnosis of the S. brasiliensis as the causative agent. The cats were treated with itraconazole associated in one case with potassium iodide. The evolution of the patients was favorable in all cases. Conclusions: An outbreak caused by S. brasiliensis was detected in domestic and feral felines in austral Chile. The correct identification of this fungus and antifungigram is essential for treatment decisions and for designing dissemination control and prevention programs under a one health approach that consider the health of people, animals, and the environment.

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“…However, this number is likely underestimated because sporotrichosis incidence is a mandatory notification only in a few states of Brazil (18).…”

Section: Introductionmentioning

confidence: 99%

Milteforan, a promising veterinary commercial product against feline sporotrichosis

García Carnero,

dos Reis,

Diehl

et al. 2024

Preprint

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Sporotrichosis, the cutaneous mycosis most commonly reported in Latin America, is caused by theSporothrixclinical clade species, includingSporothrix brasiliensisandSporothrix schenckiisensu stricto. In Brazil,S. brasiliensisrepresents a vital health threat to humans and domestic animals due to its zoonotic transmission. Itraconazole, terbinafine, and amphotericin B are the most used antifungals for treating sporotrichosis. However, many strains ofS. brasiliensisandS. schenckiihave shown resistance to these agents, highlighting the importance of finding new therapeutic options. Here, we demonstrate that milteforan, a commercial veterinary product against dog leishmaniasis whose active principle is miltefosine, is a possible therapeutic alternative for the treatment of sporotrichosis, as observed by its fungicidal activity in vitro against different strains ofS. brasiliensisandS. schenckii, and by its antifungal activity when used to treat infected epithelial cells and macrophages. Our results suggest milteforan as a possible alternative to treat feline sporotrichosis.

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Global distribution of animal sporotrichosis: A systematic review of Sporothrix sp. identified using molecular tools

Cited by 9 publications

References 35 publications

Rosmarinus officinalis and Skin: Antioxidant Activity and Possible Therapeutical Role in Cutaneous Diseases

Rosmarinus officinalis and Skin: Antioxidant Activity and Possible Therapeutical Role in Cutaneous Diseases

Sporotrichosis Outbreak Due to Sporothrix brasiliensis in Domestic Cats in Magallanes, Chile: A One-Health-Approach Study

Milteforan, a promising veterinary commercial product against feline sporotrichosis

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