2011
DOI: 10.1371/journal.pone.0018617
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Abstract: Staphylococcus aureus is a leading cause of bloodstream infections worldwide. In the United States, many of these infections are caused by a strain known as USA300. Although progress has been made, our understanding of the S. aureus molecules that promote survival in human blood and ultimately facilitate metastases is incomplete. To that end, we analyzed the USA300 transcriptome during culture in human blood, human serum, and trypticase soy broth (TSB), a standard laboratory culture media. Notably, genes encod… Show more

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Cited by 204 publications
(229 citation statements)
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References 46 publications
(62 reference statements)
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“…Staphylococcus aureus is a leading cause of bloodstream infections (BSIs) worldwide (Malachowa et al, 2011). The 2008 Mohnarin Report from China showed that S. aureus (729/10519, 6.9%) is the 3rd most common cause of BSIs in China .…”
Section: Introductionmentioning
confidence: 99%
“…Staphylococcus aureus is a leading cause of bloodstream infections (BSIs) worldwide (Malachowa et al, 2011). The 2008 Mohnarin Report from China showed that S. aureus (729/10519, 6.9%) is the 3rd most common cause of BSIs in China .…”
Section: Introductionmentioning
confidence: 99%
“…Additives such as sheep blood and calf serum cannot increase the growth rate (5,14,15). The results showed that the addition of 5% sheep blood in BHI broth could not reduce the generation time of S. aureus or increase growth rate of this bacteria, yet this enrichment compound could enhance expression of virulence genes of S. aureus.…”
Section: Discussionmentioning
confidence: 98%
“…Malachowa et al (2011) reported that expression of gamma-hemolysin gene and Pantone Valentin gene in three media cultures BHI, TSB, and CCY is different: Pantone Valentin gene was more expressed in CCY than the other two media cultures and gamma hemolysin gene showed greater expression in BHI. It is interesting that Pantone Valentin gene expression in CCY is much higher in the stationary phase than the exponential phase, while this gene is expressed more in TSB during the exponential phase, and is almost the same in BHI (14).…”
Section: Discussionmentioning
confidence: 99%
“…Most other Isd genes were also up-regulated under the conditions of this study. Furthermore, Malachowa et al (42) showed that isdA-I were all highly up-regulated (in some cases up to 200-fold) in S. aureus strain USA300 when grown in human blood or serum compared with standard media and that SAUSA300_2319 (the USA300 gene orthologous to SACOL2369) was also up-regulated in serum and blood, although not nearly to the same extent.…”
Section: Identification Of Nwmn2274 As a Putative Electron Donor Tomentioning
confidence: 99%