Global cerebral blood flow, blood volume, and oxygen metabolism in patients with migraine headache

Bednarczyk, Edward M.; Remler, Bernd F.; Weikart, C. L.; Nelson, Ashley D.; Reed, Ronald C.

doi:10.1212/wnl.50.6.1736

Cited by 79 publications

(65 citation statements)

References 1 publication

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These include reduced blood flow, blood volume, 435 and oligemia, especially the posterior circulation. 436 Another mechanism that links migraine and stroke in young adults is paradoxical embolism via a PFO.…”

Section: Migrainementioning

confidence: 99%

Primary Prevention of Ischemic Stroke

Goldstein¹,

Adams²,

Alberts

et al. 2006

Stroke

1,081

285

View full text Add to dashboard Cite

Background and Purpose-This guideline provides an overview of the evidence on various established and potential stroke risk factors and provides recommendations for the reduction of stroke risk. Methods-Writing group members were nominated by the committee chair on the basis of each writer's previous work in relevant topic areas and were approved by the American Heart Association Stroke Council's Scientific Statement Oversight Committee. The writers used systematic literature reviews (covering the time period since the last review published in 2001 up to January 2005), reference to previously published guidelines, personal files, and expert opinion to summarize existing evidence, indicate gaps in current knowledge, and when appropriate, formulate recommendations based on standard American Heart Association criteria. All members of the writing group had numerous opportunities to comment in writing on the recommendations and approved the final version of this document. The guideline underwent extensive peer review before consideration and approval by the AHA Science Advisory and Coordinating Committee. Results-Schemes for assessing a person's risk of a first stroke were evaluated. Risk factors or risk markers for a first stroke were classified according to their potential for modification (nonmodifiable, modifiable, or potentially modifiable) and strength of evidence (well documented or less well documented). Nonmodifiable risk factors include age, sex, low birth weight, race/ethnicity, and genetic factors. Well-documented and modifiable risk factors include hypertension, exposure to cigarette smoke, diabetes, atrial fibrillation and certain other cardiac conditions, dyslipidemia, carotid artery stenosis, sickle cell disease, postmenopausal hormone therapy, poor diet, physical inactivity, and obesity and body fat distribution. Less well-documented or potentially modifiable risk factors include the metabolic syndrome, alcohol abuse, drug abuse, oral contraceptive use, sleep-disordered breathing, migraine headache, hyperhomocysteinemia, elevated lipoprotein(a), elevated lipoprotein-associated phospholipase, hypercoagulability, inflammation, and infection. Data on the use of aspirin for primary stroke prevention are reviewed.

show abstract

Section: Migrainementioning

confidence: 99%

Primary Prevention of Ischemic Stroke

Goldstein¹,

Adams²,

Alberts

et al. 2006

Stroke

1,081

285

View full text Add to dashboard Cite

show abstract

“…Repeated or prolonged reduced perfusion has been described in migraine attacks, although not specifically in the pons. 11 There is evidence for impaired adaptive cerebral hemodynamic mechanisms in the posterior circulation of migraine patients. 12 We are not aware of reports on PHLs in migraine.…”

Section: Discussionmentioning

confidence: 99%

Brain Stem and Cerebellar Hyperintense Lesions in Migraine

Kruit¹,

Launer²,

Ferrari³

et al. 2006

Stroke

146

112

View full text Add to dashboard Cite

show abstract

“…Furthermore, reduction in cerebral blood flow of up to 50% has been reported in migraine patients with visual aura [30]. Repeated or prolonged episodes of oligemia during migraine attacks may selectively affect the deep and periventricular white matter, a region that is supplied by deep penetrating arterioles and potentially vulnerable to prolonged states of hypoperfusion [31,32]. In addition, matrix metalloproteinases, which are activated during cortical spreading depression in animals, cleave intercellular proteins thereby altering the extracellular matrix, leading to transient breaches of the blood-brain barrier, which may lead to ischemic brain injury [33].…”

Section: Etiology Of White Matter Lesions In Migraineursmentioning

confidence: 99%

Migraine and white matter hyperintensities

Porter¹,

Gladstone

Dodick³

2005

Current Science Inc

View full text Add to dashboard Cite

Patients with migraine are at increased risk for white matter hyperintensities detected on magnetic resonance imaging. The presence of nonspecific white matter hyperintensities may cause uncertainty for physicians and anxiety for patients. The pathophysiology and long-term consequences of these lesions are unknown. Occasionally, white matter lesions in a migraineur may indicate an underlying disease such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS), or central nervous system vasculitis. The ability to distinguish between nonspecific and disease-specific patterns of white matter hyperintensities in migraine sufferers is important for the practicing clinician.

show abstract

Global cerebral blood flow, blood volume, and oxygen metabolism in patients with migraine headache

Abstract: In patients experiencing migraine without aura, CBF and CBV are reduced during the headache phase. Cerebral oxygen metabolism and oxygen extraction are not significantly affected.

Cited by 79 publications

References 1 publication

Primary Prevention of Ischemic Stroke

Primary Prevention of Ischemic Stroke

Brain Stem and Cerebellar Hyperintense Lesions in Migraine

Migraine and white matter hyperintensities

Contact Info

Product

Resources

About