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Cited by 42 publications
(31 citation statements)
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“…But at present, the underlying mechanism of IDH mutations in tumorigenesis and their prognostic significance is still not clear (39). Further research should be undertaken to open entire new horizon of potential individualized treatment tailored to gene expression profiling and clinical trials for glioma (40).…”
Section: Log-rankmentioning
confidence: 99%
“…But at present, the underlying mechanism of IDH mutations in tumorigenesis and their prognostic significance is still not clear (39). Further research should be undertaken to open entire new horizon of potential individualized treatment tailored to gene expression profiling and clinical trials for glioma (40).…”
Section: Log-rankmentioning
confidence: 99%
“…A recent cancer genome-sequencing project revealed that the gene encoding isocitrate dehydrogenases 1 (IDH1) was somatically mutated predominantly in secondary GBM (Fu et al 2010;Zhao et al 2009). However, the frequency of IDH2 mutation in these gliomas was low.…”
Section: Introductionmentioning
confidence: 99%
“…This aspect of the activity of NADPH-producing dehydrogenases warrants further study. The IDH1 and IDH2 gene mutations are linked with gliomagenesis, acute myeloid leukemia, and thyroid cancer because of 2-hydroxyglutarate production, which is considered an oncometabolite (Dang et al 2009;Ward et al 2010;Fu et al 2010;Gross et al 2010). However, it was recently found that glioblastoma cells expressing mutant IDH1 show reduced growth when α-ketoglutarate production via glutaminase is inhibited as well (Seltzer et al 2010), indicating that not only production of the oncometabolite is involved in gliomagenesis but also reduced production of α-ketoglutarate and/or NADPH.…”
Section: Discussionmentioning
confidence: 99%