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Cited by 47 publications
(25 citation statements)
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“…Reduced levels of α-KG and Fe 2+ in mutant IDH cells may therefore promote cellular accumulation of HIF-1α. Activation of this pathway leads to the induction of HIF-1 target genes that affect angiogenesis, metabolism, growth and differentiation, apoptosis and autophagy, as well as cell motility [51]. Zhao et al .…”
Section: Idh Mutations and The Hypoxia Pathwaymentioning
confidence: 99%
“…Reduced levels of α-KG and Fe 2+ in mutant IDH cells may therefore promote cellular accumulation of HIF-1α. Activation of this pathway leads to the induction of HIF-1 target genes that affect angiogenesis, metabolism, growth and differentiation, apoptosis and autophagy, as well as cell motility [51]. Zhao et al .…”
Section: Idh Mutations and The Hypoxia Pathwaymentioning
confidence: 99%
“…One major issue is to understand the mechanism of reduced invasiveness with IDH mutations. Studies of glioma cells with IDH-2 mutation show upregulation of hypoxia-inducible factor-1a and b-catenin (33), which leads to increased secretion of metalloproteinases (34). This promotes glioma cell invasion, without the need for hypoxia to induce these hypoxia-inducible factor-1a mechanisms.…”
Section: Minimal Invasive Phenotype Detection Of Idh-1 R132h Mutationmentioning
confidence: 99%
“…Jing et al [19] found that hypoxia-induced invasion and metastasis of esophageal carcinoma was attributed to the distinctive capacity of HIF-1α in inhibiting E-cadherin and promoting matrix metalloproteinase-2 expression. The vascular endothelial growth factor, cyclooxygenase-2 and isocitrate dehydrogenase-2 were also found to be involved in the regulation of HIF-1α signaling pathway for cancer angiogenesis, invasiveness and metastasis [2022]. …”
Section: Discussionmentioning
confidence: 99%