2014
DOI: 10.1002/stem.1605
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Abstract: Background: Translational medicine aims at transferring advances in basic science research into new approaches for diagnosis and treatment of diseases. Low-grade gliomas (LGG) have a heterogeneous clinical behavior that can be only partially predicted employing current state-of-theart markers, hindering the decision-making process. To deepen our comprehension on tumor heterogeneity, we dissected the mechanism of interaction between tumor cells and relevant components of the neoplastic environment, isolating, f… Show more

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Cited by 80 publications
(91 citation statements)
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References 63 publications
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“…Functional assays on exosomes-exposed cell cultures A172 cell cultures are known to show higher motility rates upon exposure to GASC extracted exosomes [23]. We wanted to verify whether the preferential uptake of GASC exosomal fractions extracted with EQ was able to trigger a more prominent response compared to UC extractions.…”
Section: Cellular Uptake Of Exosomal Fractions With Different Size DImentioning
confidence: 99%
See 1 more Smart Citation
“…Functional assays on exosomes-exposed cell cultures A172 cell cultures are known to show higher motility rates upon exposure to GASC extracted exosomes [23]. We wanted to verify whether the preferential uptake of GASC exosomal fractions extracted with EQ was able to trigger a more prominent response compared to UC extractions.…”
Section: Cellular Uptake Of Exosomal Fractions With Different Size DImentioning
confidence: 99%
“…Apart from their potential use as therapeutics, exosomes could be used as predictors of disease status [22]. For example, Glioma-Associated Stem Cells (GASC), a population of stem cells isolated from the glioma microenvironment and endowed with a significant prognostic potential, exert their tumour supporting activity through the release of exosomes [23]. Also in this context, besides the already well-studied molecular profiles, a better understanding of the physical properties of exosomes might be informative and useful to predict the clinical outcome of diseases [24].…”
Section: Introductionmentioning
confidence: 99%
“…These non-tumorigenic cells were named to be glioma associated stem cells (GASC) (Bourkoula et al 2013), tumor associated mesenchymal stromal cells (TAMSC) (Hossain et al 2011), brain tumor derived-mesenchymal stem cell (BTD-MSC) (Behnan et al 2014) and tumor mesenchymal stem like cells (tMSLCs) (Kim et al 2011Kwak et al 2013;Lim et al 2013). It is reported that GASC plays a role to predict the progression of the low grade glioma (Bourkoula et al 2013), BTD-MSC is relevant to tumor progression (Behnan et al 2014) and MSCL is associated with the increase in angiogenesis (Shin et al Fig.…”
Section: Non-tumorigenic Stromal Cells In Gbmmentioning
confidence: 99%
“…It is reported that GASC plays a role to predict the progression of the low grade glioma (Bourkoula et al 2013), BTD-MSC is relevant to tumor progression (Behnan et al 2014) and MSCL is associated with the increase in angiogenesis (Shin et al Fig. 1 One example of our GBM TS data set.…”
Section: Non-tumorigenic Stromal Cells In Gbmmentioning
confidence: 99%
“…Using the CGGA mRNA microarray database, 27 LVCGs and 16 NLVCGs were compared for the expression of stemness genes, including CD34, CD44, vimentin, N-cadherin, Nanog, CD133, Sry-box 2, Oct-4, and CD117 [21,22]. Cluster and Pearson correlation analyses showed that the expression of these genes did not correlate with LVC (Fig.…”
Section: Expression Profiles Of Lvcgs and Nlvcgsmentioning
confidence: 99%