2010
DOI: 10.1158/1535-7163.mct-09-0734
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Glioblastoma multiforme (GBM) is a lethal cancer that responds poorly to radiotherapy and chemotherapy. Glioma cancer-initiating cells have been shown to recapitulate the characteristic features of GBM and mediate chemotherapy and radiation resistance. However, it is unknown whether the cancer-initiating cells contribute to the profound immune suppression in GBM patients. Recent studies have found that the activated form of signal transducer and activator of transcription 3 (STAT3) is a key mediator in GBM imm… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

3
206
1
5

Year Published

2010
2010
2023
2023

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 248 publications
(215 citation statements)
references
References 62 publications
3
206
1
5
Order By: Relevance
“…Recent reports have defined an immuneinhibitory phenotype specifically of GIC (Di Tomaso et al, 2010;Wei et al, 2010a;Wei et al, 2010b). Here, we define a possible role of the atypical HLA molecule,…”
Section: Discussionmentioning
confidence: 88%
See 1 more Smart Citation
“…Recent reports have defined an immuneinhibitory phenotype specifically of GIC (Di Tomaso et al, 2010;Wei et al, 2010a;Wei et al, 2010b). Here, we define a possible role of the atypical HLA molecule,…”
Section: Discussionmentioning
confidence: 88%
“…These immunosuppressive functions of GIC seem to depend on the constitutive activation of the STAT-3 pathway, a potent anti-inflammatory regulatory pathway (Wei et al, 2010a). Moreover, a defective antigen processing machinery in GIC underscores their ability to evade a T cell-mediated immune response (Di Tomaso et al, 2010).…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, glioma-associated CSCs/CICs have been reported to be related to immunosuppression through B7-H1 and soluble Galectin-3 and STAT3 signaling (49,50). These observations suggest that CSCs/CICs might suppress the CTL induction phase but might not affect the CTL effector phase.…”
Section: Discussionmentioning
confidence: 99%
“…Targeting these pathways inhibits STAT3 activation, and cell growth and self-renewal in GSCs (Cao et al, 2010;Wang et al, 2009). Interestingly, STAT3 also contributes to the immune regulation by GSCs (Wei et al, 2010). Because STAT3 is involved in many cellular activities in a wide range of cell types including normal stem cells, STAT3 may not be a specific target for GSCs, although STAT3 inhibitors are undergoing clinical development.…”
Section: Stat3 Signalingmentioning
confidence: 99%