Biochemical Pharmacology volume 76, issue 12, P1705-1715 2008 DOI: 10.1016/j.bcp.2008.09.009 View full text
Xia Qian, Jing Li, Jianhua Ding, Zhiyuan Wang, Lei Duan, Gang Hu

Abstract: Glibenclamide, a blocker of ATP-sensitive potassium (K(ATP)) channels, can suppress progression of many cancers, but the involved mechanism is unclear. Herein we reported that MGC-803 cells expressed the K(ATP) channels composed of Kir6.2 and SUR1 subunits. Glibenclamide induced cellular viability decline, coupled with cell apoptosis and reactive oxygen species (ROS) generation in MGC-803 cells. Meanwhile, glibenclamide increased NADPH oxidase catalytic subunit gp91(phox) expression and superoxide anion (O2-) …

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