Biochemical Pharmacology volume 82, issue 2, P148-155 2011 DOI: 10.1016/j.bcp.2011.04.001 View full text
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Tao-Hua Lan, Zhi-Wei Xu, Zhi Wang, Yi-Ling Wu, Wei-Kang Wu, Hong-Mei Tan

Abstract: Hyperhomocysteinemia (HHcy), a risk factor for cardiovascular disease, is associated with endothelial dysfunction. Ginsenoside Rb1, the major active constituent of ginseng, potently attenuates homocysteine (Hcy)-induced endothelial damage. However, the underlying mechanism remains unknown. In this study, we have investigated the effect of Ginsenoside Rb1 on Hcy-induced endothelial dysfunction and its underlying signal pathway in vivo and in vitro. Ginsenosides prevented Hcy-induced impairment of endothelium-de…

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