Ginseng (Panax ginseng) leaf extract modulates the expression of heme oxygenase-1 to attenuate osteoclast differentiation

Lee, Hyuk Gyoon; Hur, Jinwoo; Won, Jun Pil; Seo, Han Geuk

doi:10.1016/j.fitote.2024.105831

Fitoterapia

2024

DOI: 10.1016/j.fitote.2024.105831

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Ginseng (Panax ginseng) leaf extract modulates the expression of heme oxygenase-1 to attenuate osteoclast differentiation

Hyuk Gyoon Lee,

Jinwoo Hur,

Jun Pil Won

et al.

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2024

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Cited by 2 publications

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New potential selective estrogen receptor modulators in traditional Chinese medicine for treating menopausal syndrome

Song,

Shen,

Contreras

et al. 2024

Phytotherapy Research

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Women go through several predictable conditions and symptoms during menopause that are caused by age, changes in sex hormone levels, and other factors. Conventional menopause hormone therapy has raised serious concerns about the increased risks of cancers, blood clots, depression, etc. Selective estrogen receptor modulators (SERMs) that can be both agonists and antagonists of estrogen receptors in a tissue‐specific manner are being developed to reduce the health concerns associated with menopause hormone therapy. Here, we have searched the Chinese national traditional Chinese medicine (TCM) patent database to identify potential SERM‐like compounds with reduced health risks. TCM has been widely used for treating complex symptoms associated with menopause syndrome and thus can be a particularly rich source for pharmaceutical alternatives with SERM properties. After extensive literature review and molecular simulation, we conclude that protopanaxatriol, paeoniflorin, astragalin, catalpol, and hyperoside among others may be particularly promising as SERM‐like compounds in treating the menopausal syndrome. Compounds in TCM hold promise in yielding comparable outcomes to hormone therapy but with reduced associated risks, thus presenting promising avenues for their clinical applications.

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New potential selective estrogen receptor modulators in traditional Chinese medicine for treating menopausal syndrome

Song,

Shen,

Contreras

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

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Oxidation of hydrogen peroxide by tungstate ion: formation and decay of a long-lived intermediate

Perez-Benito,

Salido-Pons

2024

Reac Kinet Mech Cat

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Ginseng (Panax ginseng) leaf extract modulates the expression of heme oxygenase-1 to attenuate osteoclast differentiation

Cited by 2 publications

References 45 publications

New potential selective estrogen receptor modulators in traditional Chinese medicine for treating menopausal syndrome

New potential selective estrogen receptor modulators in traditional Chinese medicine for treating menopausal syndrome

Oxidation of hydrogen peroxide by tungstate ion: formation and decay of a long-lived intermediate

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