Gingivitis and lifestyle influences on high‐sensitivity C‐reactive protein and interleukin 6 in adolescents

Pitchika, Vinay; Thiering, Elisabeth; Metz, Isabel; Rothmaier, Katrin; Willenberg, Anja; Hickel, Reinhard; Standl, Marie; Kocher, Thomas; Heinrich, Joachim; Kühnisch, Jan

doi:10.1111/jcpe.12690

Cited by 21 publications

(17 citation statements)

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“…Shojaee et al () reported a significant difference and positive correlation between salivary CRP concentrations and periodontitis disease status among healthy subjects. Many studies investigating CRP levels in the serum and GCF found similar results (George & Janam, ; Kanaparthy, Kanaparthy, & Mahendra, ; Pitchika et al, ; Pitiphat, Savetsilp, & Wara‐Aswapati, ). Our study is one of the few studies that compared salivary CRP concentrations of healthy subjects and patients with gingivitis and periodontitis.…”

Section: Discussionmentioning

confidence: 59%

Salivary fetuin‐A, S100A12, and high‐sensitivity C‐reactive protein levels in periodontal diseases

et al. 2018

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Section: Discussionmentioning

confidence: 59%

Salivary fetuin‐A, S100A12, and high‐sensitivity C‐reactive protein levels in periodontal diseases

et al. 2018

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“…Second, control of potential confounders through adequate statistical analyses (e.g., multivariate models) was applied only in some studies. 187,188 Overall, the above mentioned findings seem to demonstrate that the inflammation of marginal gingival tissues determines an increase in systemic inflammation, assessed in terms of CRP levels. However, other studies have failed to demonstrate potentially relevant systemic effects during gingivitis development.…”

Section: Systemic Inflammation Markers (Crp)mentioning

confidence: 78%

“…First, criteria for GC definition varied greatly among studies. Second, control of potential confounders through adequate statistical analyses (e.g., multivariate models) was applied only in some studies . Overall, the above mentioned findings seem to demonstrate that the inflammation of marginal gingival tissues determines an increase in systemic inflammation, assessed in terms of CRP levels.…”

Section: Methodsmentioning

confidence: 99%

“…While in some studies CRP levels were found to be significantly positively correlated with papillary bleeding index 186 or GI, 184 other authors failed to find an association between CRP levels and GI, 185 BOP, 185,187 or the number of sextants with at least one BOP+ site. 188 Certain factors may have contributed to the heterogeneity among these findings. First, criteria for GC definition varied greatly among studies.…”

Section: Systemic Inflammation Markers (Crp)mentioning

confidence: 99%

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Plaque‐induced gingivitis: Case definition and diagnostic considerations

Trombelli

Farina

Silva

et al. 2018

J Clinic Periodontology

260

212

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Based on available methods to assess gingival inflammation, GC could be simply, objectively and accurately identified and graded using bleeding on probing score (BOP%) CONCLUSIONS: A patient with intact periodontium would be diagnosed as a GC according to a BOP score ≥ 10%, further classified as localized (BOP score ≥ 10% and ≤30%) or generalized (BOP score > 30%). The proposed classification may also apply to patients with a reduced periodontium, where a GC would characterize a patient with attachment loss and BOP score ≥ 10%, but without BOP in any site probing ≥4 mm in depth.

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“…Children born in the Munich centre who had available dental examination data and dietary information were included in this study. Details concerning the study's background, representative recruitment strategy, inclusion and exclusion criteria have been described elsewhere [15][16][17]. In this study, a total of 915 (GINIplus: 557; LISAplus: 358) and 996 (GINIplus: 652; LISAplus: 344) participants were included from the 10-and 15-year follow-ups, respectively.…”

Section: Study Populationmentioning

confidence: 99%

Association of sugar-sweetened drinks with caries in 10- and 15-year-olds

et al. 2020

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Background: Sugar-sweetened drinks (SSDs) are known to be cariogenic, but this association has not been well investigated in population-based repeated cross-sectional studies in recent years. Therefore, this study examined whether SSD intake is associated with higher caries experience in 10-and 15-year-olds. Methods: The study sample included participants from the Munich study centre of two birth cohorts with data on non-cavitated caries lesions (NCCL/S), caries experience (DMF/S index), overall caries burden (DMF + NCCL/S) and SSD intake. In total, 915 and 996 children were included from the 10-and 15-year follow-ups, respectively. Intake (g/day) of SSDs, comprising cola, lemonade, ice-tea, sport/energy drinks, fruit squashes and nectars, was calculated from food frequency questionnaires. For analyses, the SSD intake was converted into portions (250 ml/day). Multiple logistic regression and prospective analysis models were performed to test associations between SSD intake and various definitions of caries, adjusting for sex, parental education, body mass index (BMI) categories, study cohort, plaque-affected sextants, mode of SSD consumption, energy content of SSDs, and total energy intake. Results: The mean overall caries burden at 10 and 15 years of age was 1.81 (SD: 2.71) and 6.04 (SD: 8.13), respectively. The average consumption of SSDs at the 10-and 15-year follow-ups was 0.48 (SD: 0.85) and 0.83 (SD 1.40) portions/day, respectively. After adjusting for confounders, in 10-year-olds, SSD intake was significantly associated with higher caries experience based on the indices DMF/S (adjusted odds ratio: 1.29; 95% CI: 1.06-1.57), NCCL/S (1.24; 1.03-1.49) and DMF + NCCL/S (1.27; 1.05-1.55). At the 15-year follow-up, SSD consumption was significantly associated with increased DMF/S index (1.12; 1.01-1.25) only. Prospective model associating 10-year SSD intake with 15-year caries experience was not significant. Conclusions: SSD intake significantly increases the caries burden in 10-year-olds, with attenuated effects in 15-year-olds. To prevent caries, SSD consumption should be reduced, especially in children and adolescents.

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Gingivitis and lifestyle influences on high‐sensitivity C‐reactive protein and interleukin 6 in adolescents

Abstract: In this study, hs-CRP was positively associated with gingivitis, smoking daily and overweight/obesity among 15-year-olds.

Cited by 21 publications

References 50 publications

Salivary fetuin‐A, S100A12, and high‐sensitivity C‐reactive protein levels in periodontal diseases

Salivary fetuin‐A, S100A12, and high‐sensitivity C‐reactive protein levels in periodontal diseases

Plaque‐induced gingivitis: Case definition and diagnostic considerations

Association of sugar-sweetened drinks with caries in 10- and 15-year-olds

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