Gingival sequestration of nifedipine in nifedipine-induced gingival overgrowth

Ellis, J. S.; Seymour, R. A.; Monkman, S. C.; Idle, J R

doi:10.1016/0140-6736(92)91199-i

Cited by 49 publications

(25 citation statements)

References 8 publications

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“…Nifedipine is found in significantly higher levels in gingival crevicular fluid in nifedipine induced-gingival lesions (18,19), and we have previously demonstrated that nifedipine stimulates cell proliferation in human gingival fibroblasts, particularly those from nifedipine responders (2).…”

Section: Discussionmentioning

confidence: 99%

“…IL-1α predominates (16) in gingival crevicular fluid and a greater amount of nifedipine is found in gingival crevicular fluid in the patients with periodontal disease (19,20). The aim of this study was thus to investigate the simultaneous effect of nifedipine and IL-1α on cell proliferation and DNA synthesis of gingival fibroblasts from nifedipine responders and non-responders.…”

Section: Introductionmentioning

confidence: 99%

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The effect of IL-l.ALPHA. and nifedipine of cell proliferation and DNA synthesis in cultured human gingival fibroblasts

et al. 2005

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The effect of nifedipine and interleukin-α (IL-1α) on the cell proliferation and DNA synthesis was studied in human gingival fibroblasts derived from 5 patients who developed gingival overgrowth (nifedipine responders) and 5 patients who did not develop gingival overgrowth (nifedipine non-responders) in response to nifedipine. Epidermal growth factor was used as a positive control. The fibroblasts derived from nifedipine responders tended to have a numerically greater rate of cell proliferation and DNA synthesis ( 3 H-thymidine incorporation) than those from nifedipine nonresponders in the presence of nifedipine and IL-1α. Fibroblasts derived from nifedipine responders showed significantly higher cell proliferation rate in the presence of nifedipine and IL-1α, than nifedipine or IL-1α alone on both the second and the fourth day of incubation (P < 0.05). A combination of IL-1α and epidermal growth factor also showed significantly greater cell proliferation than IL-1α alone on the second day (P < 0.05). The DNA synthesis rate with a combination of nifedipine and IL-1α was higher than that for nifedipine alone on the second day (P < 0.01), and IL-1α alone on the fourth day (P < 0.05) in gingival fibroblasts originating from nifedipine responders. These results suggest that the interaction between nifedipine and gingival inflammation might play an important role in the pathogenesis of nifedipine-induced gingival overgrowth. (J. Oral Sci. 47, [105][106][107][108][109][110] 2005)

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effect of IL-l.ALPHA. and nifedipine of cell proliferation and DNA synthesis in cultured human gingival fibroblasts

et al. 2005

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“…[7,13] Ellis'in çal›flmas›nda gingival sekresyonda nifedipin konsantrasyonunun plazmadan 13-316 kez fazla oldu¤u ve gingival sekresyonda düflük düzeyde nifedipin konsantrasyonu olanlarda difleti büyümesinin olmad›¤› gösterilmifltir. [14] Olgumuzdaki hasta ilac› yüksek dozda, üç y›l gibi uzun bir süredir kullanmaktayd›. ‹laca ba¤l› difleti büyümelerinin tedavisinde; baz› hastalarda hasta veya difl hekimi taraf›ndan normal a¤›z hijeninin sa¤lanmas› yeterlidir; a¤›z hijyeni cerrahi (gingivektomi) giriflim ihtiyac›n› azalt›r.…”

Section: Tart›flmaunclassified

Nifedipine-induced gingival overgrowth: a case report

Yıldırım¹,

Tan²

2014

Turk Aile Hek Derg

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“…La ciclosporine et le tacrolimus potentialisent certains effets indésirables des anticalciques : la gynécomastie n'est pas rare chez le sujet greffé recevant l'association ciclosporine + anticalcique alors qu'elle est exceptionnelle sous anticalcique seul [30,31]. En revanche, le tacrolimus n'engendre pas de gynécomastie ; l'hyperplasie gingivale est banale sous ciclosporine, surtout en début de greffe lorsque les doses de ciclosporine sont élevées [32,33]. Elle est encore plus fréquente sous ciclosporine + anticalcique (figure 2).…”

Section: Interactions Anticalciques/ciclosporine Ou Tacrolimusunclassified

Le cardiologue et les immunosuppresseurs

Ambrosi

Lafforgue

2012

La Presse Médicale

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Gingival sequestration of nifedipine in nifedipine-induced gingival overgrowth

Cited by 49 publications

References 8 publications

The effect of IL-l.ALPHA. and nifedipine of cell proliferation and DNA synthesis in cultured human gingival fibroblasts

The effect of IL-l.ALPHA. and nifedipine of cell proliferation and DNA synthesis in cultured human gingival fibroblasts

Nifedipine-induced gingival overgrowth: a case report

Le cardiologue et les immunosuppresseurs

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