Gingival crevicular fluid transforming growth factor-β1 in several forms of periodontal disease

Changes in Transforming Growth Factor- β 1 in Gingival Crevicular Fluid of Patients with Chronic Periodontitis Following Periodontal Flap Surgery

“…However, the increase in TGF-β1 levels at two weeks post-surgery interval in his study was not statistically significant. In view of the clinical outcomes of periodontal surgery observed by various authors [10][11][12], it is likely that the GCF samples collected from surgically treated sites represent wound fluid associated with periodontal repair and regeneration and this could explain the varying levels of GCF TGF-β1 in the course of this study.…”

“…The precise role of TGF-β1 in periodontal wound healing remains unclear and studies done by Skaleric et al, [10] Ko et al, [11] and Gürkan et al, [12] have shown that concentration of TGF-β1 of gingival tissue exhibits dynamic changes associated with the progression of experimental periodontal inflammation and the levels of TGF-β1 in gingival tissue may be valuable in detecting the inflammatory reaction of periodontal tissues.…”

Growth Factors and Connective Tissue Homeostasis in Periodontal Disease

“…Research in this area has reported the assessment of GCF and salivary levels of several growth factors for their potential to diagnose periodontal disease, including EGF, TGF-, PDGF, HGF, and VEGF (Buduneli et al, 2001b;Chang et al, 1996;Gurkan et al, 2006;Hormia et al, 1993;Kamimoto et al, 2002;Sakallioglu et al, 2007;Wilczynska-Borawska et al, 2006).…”

Serum leptin levels and their proportional relationship with pro- and antiinflammatory mediators in aggressive periodontitis: preliminary report

“…The functional properties of TGF-β were determined and reported as cell growth regulation, differentiation and matrix production, and remodeling in both soft and mineralized connective tissues (26,27).…”