Ginger—Mechanism of action in chemotherapy-induced nausea and vomiting: A review

Marx, Wolfgang; Ried, Karin; McCarthy, Alexandra; Vitetta, Luis; Sali, Avni; McKavanagh, Daniel; Isenring, Elisabeth

doi:10.1080/10408398.2013.865590

Cited by 116 publications

(114 citation statements)

References 47 publications

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“…First, this study has demonstrated that both ginger extracts and the compounds, 6-gingerol and 6-shogaol, noncompetitively inhibited 5-HT 3 receptor activation. This provides both support for ginger interacting with the 5-HT 3 receptors in humans but also provides additional evidence that these compounds bind to a currently unknown binding site, distinct from other types of 5-HT 3 ] noted, this may allow for potentially synergistic inhibition of 5-HT 3 signalling when combined with standard 5-HT 3 antagonists (e.g. ondansetron, a common antiemetic during chemotherapy and surgery).…”

Section: Mechanisms Of Actionmentioning

confidence: 87%

“…Ginger contains a wide array of bioactive compounds, which have been investigated for their effects on nausea and vomiting. Multiple potential mechanisms of action have been identified including 5-HT 3 receptor antagonism, antiinflammatory properties, and the modulation of gastrointestinal motility [3]. Clinical studies have also reported promising results, and ginger has now been investigated as a treatment for a several types of nausea including motion sickness, postoperative nausea and vomiting, morning sickness, and chemotherapy-induced nausea and vomiting (CINV) [4].…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Is ginger beneficial for nausea and vomiting? An update of the literature

Marx

Kiss

Isenring

2015

Current Opinion in Supportive &Amp; Palliative Care

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Section: Mechanisms Of Actionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 98%

Is ginger beneficial for nausea and vomiting? An update of the literature

Marx

Kiss

Isenring

2015

Current Opinion in Supportive &Amp; Palliative Care

Self Cite

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“…These receptors are expressed in the central nervous system in regions involved in gag reflex and vomiting . Receptor antagonists, such as ondansetron, are used as a standard of care postoperatively and in controlling chemotherapy‐induced nausea and vomiting . Moreover, 5‐HT 3 receptors have been linked to peristaltic activity in the GI tract, as shown by antagonism altering GI motility in vitro .…”

Section: Methodsmentioning

confidence: 99%

Natural Bioactive Food Components for Improving Enteral Tube Feeding Tolerance in Adult Patient Populations

2017

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Tube feeding (TF) is the most common form of nutrition support. In recent years, TF administration has increased among patient populations within and outside hospital settings, in part due to greater insurance coverage, reduced use of parenteral nutrition, and improved formularies suitable for sole source nutrition. With increasing life expectancy and improved access to TFs, the number of adults dependent on enteral nutrition is expected to grow. However, enteral TF intolerance (ETFI) is the most common complication of TFs, typically presenting with at least 1 adverse gastrointestinal event, including nausea, diarrhea, and constipation. ETFI often leads to reductions in TF volume with associated energy and protein deficits. Potentially ensuing malnutrition is a major public health concern due its effects on increased risk of morbidity and mortality, infections, prolonged hospital length of stay, and higher healthcare costs. As such, there is a need for intervention strategies to prevent and reduce ETFI. Incorporating whole foods with bioactive properties is a promising strategy. Emerging research has elucidated bioactive properties of whole foods with specific benefits for the prevention and management of adverse gastrointestinal events commonly associated with TFs. However, lack of evidence-based recommendations and technological challenges have limited the use of such foods in commercial TF formulas. This review addresses research gaps by discussing 5 whole foods (rhubarb, banana, curcumin, peppermint oil, and ginger) with bioactive attributes identified through literature searches and clinical experience as having substantial scientific rationale to consider their application for ETFI in adult populations. (Nutr Clin Pract. 2018;33:107-120) Keywords enteral nutrition; enteral formulas; tube feeding; dietary supplements; digestive signs and symptoms SummaryTube feeding (TF) is the most common form of nutrition support. In recent years, TF administration has increased among patient populations within and outside hospital settings, in part due to greater insurance coverage, reduced use of parenteral nutrition (PN), and improved formularies suitable for sole source nutrition. With increasing life expectancy and improved access to TFs, the number of adults dependent on enteral nutrition (EN) is expected to grow. However, enteral TF intolerance (ETFI) is the most common complication of TFs, typically presenting with at least 1 adverse gastrointestinal (GI) event, including nausea, diarrhea, and constipation. ETFI often leads to reductions in TF volume with associated energy and protein deficits. Potentially ensuing malnutrition is a major public health concern due its effects on increased risk of morbidity and mortality, infections, prolonged hospital length of stay, and higher healthcare costs. As such, there is a need for intervention strategies to prevent and reduce ETFI. Incorporating whole foods with bioactive properties is a promising strategy. Emerging research has elucidated bioactive properties ...

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“…Ginger, Zingiber officinale roscoe rhizomes ( Zingiberaceae ), is one of the most commonly consumed spices worldwide. Ginger has been used as an herbal medicine to relieve nausea/vomiting and gastrointestinal discomforts (bloating and pain), but the cellular and molecular mechanisms of its neuronal actions are still unclear . It is known that the pharmacological effect of ginger is mainly produced by its bioactive phytochemicals, including the pungent principle gingerols (including 4‐, 6‐, 8, 10‐, and 12‐gingerols) and their more bioactive dehydrated products, the shogaols (including 6‐, 8‐, and 10‐shogaols) …”

Section: Introductionmentioning

confidence: 99%

“…Secondly, as herbal medicine, ginger is known for its anti‐emesis effect. Vagal afferents in the GI tract play an important role in mediating emetic sensation and reflex . Thus, ginger might display its anti‐emesis effect through its interaction with vagal afferents in the GI tract.…”

Section: Introductionmentioning

confidence: 99%

Effects of ginger constituent 6‐shogaol on gastroesophageal vagal afferent C‐fibers

Huang

Patil

et al. 2019

Neurogastroenterology Motil

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Background Ginger has been used as an herbal medicine worldwide to relieve nausea/vomiting and gastrointestinal discomfort, but the cellular and molecular mechanisms of its neuronal action remain unclear. The present study aimed to determine the effects of ginger constituent 6‐shogaol on gastroesophageal vagal nodose C‐fibers. Methods Extracellular single‐unit recording and two‐photon nodose neuron imaging were performed, respectively, in ex vivo gastroesophageal‐vagal preparations from wild type and Pirt‐GCaMP6 transgenic mice. The action potential discharge or calcium influx evoked by mechanical distension and chemical perfusions applied to the gastroesophageal vagal afferent nerve endings were recorded, respectively, at their intact neuronal cell soma in vagal nodose ganglia. The effects of 6‐shogaol on nodose C‐fiber neurons were then compared and determined. Key Results Gastroesophageal application of 6‐shogaol‐elicited intensive calcium influxes in nodose neurons and evoked robust action potential discharges in most studied nodose C‐fibers. Such activation effects were followed by a desensitized response to the second application of 6‐shogaol. However, action potential discharges evoked by esophageal mechanical distension, after 6‐shogaol perfusion, did not significantly change. Pretreatment with TRPA1 selective blocker HC‐030031 inhibited 6‐shogaol‐induced action potential discharges in gastric and esophageal nodose C‐fiber neurons, suggesting that TRPA1 played a role in mediating 6‐shogaol‐induced activation response. Conclusion and Inferences This study provides evidence that ginger constituent 6‐shogaol directly activates vagal afferent C‐fiber peripheral gastrointestinal endings. This activation leads to desensitization to subsequent application of 6‐shogaol but not subsequent esophageal mechanical distension. Further investigation is required to establish a possible contribution in its anti‐emetic effects.

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Ginger—Mechanism of action in chemotherapy-induced nausea and vomiting: A review

Cited by 116 publications

References 47 publications

Is ginger beneficial for nausea and vomiting? An update of the literature

Is ginger beneficial for nausea and vomiting? An update of the literature

Natural Bioactive Food Components for Improving Enteral Tube Feeding Tolerance in Adult Patient Populations

Effects of ginger constituent 6‐shogaol on gastroesophageal vagal afferent C‐fibers

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