Gilles de la Tourette syndrome and voluntary movement: A functional MRI study

Fattapposta, Francesco; Restuccia, Rita; Colonnese, Claudio; Labruna, Ludovica; Garreffa, Girolamo; Bianco, Federico

doi:10.1016/j.pscychresns.2005.02.001

Cited by 23 publications

(16 citation statements)

References 15 publications

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“…Accordingly, functional coupling between SMA and M1 increases immediately before the execution of voluntary movements [34], [35], [36]. In the literature increased SMA activation has been reported in GTS [16], [17] during the performance of voluntary movements, a result that was not confirmed by the present data. Increased SMA activation in GTS has further been related to sensory urges [37], [38], [39].…”

Section: Discussioncontrasting

confidence: 81%

“…These measures reveal precise information about the temporal distribution of cortical activation patterns. Using functional magnetic resonance imaging (fMRI) two studies reported increased activation of primary sensorimotor and secondary motor cortices (primarily SMA) during the execution of a finger-tapping task [16], [17]. However, these analyses did not reveal information about a direct functional interaction between brain areas.…”

Section: Introductionmentioning

confidence: 99%

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Motor-Cortical Interaction in Gilles de la Tourette Syndrome

et al. 2012

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BackgroundIn Gilles de la Tourette syndrome (GTS) increased activation of the primary motor cortex (M1) before and during movement execution followed by increased inhibition after movement termination was reported. The present study aimed at investigating, whether this activation pattern is due to altered functional interaction between motor cortical areas.Methodology/Principal Findings10 GTS-patients and 10 control subjects performed a self-paced finger movement task while neuromagnetic brain activity was recorded using Magnetoencephalography (MEG). Cerebro-cerebral coherence as a measure of functional interaction was calculated. During movement preparation and execution coherence between contralateral M1 and supplementary motor area (SMA) was significantly increased at beta-frequency in GTS-patients. After movement termination no significant differences between groups were evident.Conclusions/SignificanceThe present data suggest that increased M1 activation in GTS-patients might be due to increased functional interaction between SMA and M1 most likely reflecting a pathophysiological marker of GTS. The data extend previous findings of motor-cortical alterations in GTS by showing that local activation changes are associated with alterations of functional networks between premotor and primary motor areas. Interestingly enough, alterations were evident during preparation and execution of voluntary movements, which implies a general theme of increased motor-cortical interaction in GTS.

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Section: Discussioncontrasting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Motor-Cortical Interaction in Gilles de la Tourette Syndrome

et al. 2012

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“…For instance, earlier findings with small cohorts of TS adults showed problems in the finger tapping task and correlated with dysfunction of the supplementary motor area as documented by brain imaging (Biswal et al, 1998;Fattapposta et al, 2005). However, similar results from fine motor skills and dexterity obtained at the PPT in the current study are consistent with an earlier investigation with a comparable population (O'Connor, 2005a) and support the interpretation that the ability of the patient groups to reproduce a complex geometric figure, such as the ROCF, is probably not mediated by a fine motor dexterity problem.…”

Section: Discussionmentioning

confidence: 91%

Memory and executive functions in adults with Gilles de la Tourette syndrome and chronic tic disorder

Lavoie

Thibault

Stip

et al. 2007

Cognitive Neuropsychiatry

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Introduction-The main aim of the current study was to assess whether adults with either Tourette syndrome (TS) or chronic tic disorder (CTD) show a similar neuropsychological profile. Neuropsychological investigations of tic disorders have been mostly focused on children, mainly because symptoms peak during that period. Little has been carried out on adults, even if a significant proportion of the tic population experience moderate or marked levels of tic frequency throughout adulthood. Still, it is not clear whether neuropsychological performances are affected to the same degree in adults with TS and CTD.

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“…Despite the fact that there have been some reports on voluntary fine motor function in TS [Biswal et al, 1998;Bornstein, 1990;Bornstein et al, 1991;Fattapposta et al, 2005;Hagin et al, 1982;Schultz et al, 1998], our study has the advantage of fairly large sample of patients at an early disease stage without comorbid symptomatology. Although usual clusters of motor activation patterns reported in finger-tapping studies were similar in both groups [Witt et al, 2008], that is, contralateral primary sensorimotor cortex, supplementary motor areas, and ipsilateral cerebellum), this study also found BOLD signal differences between both groups.…”

Section: Discussionmentioning

confidence: 99%

Altered motor network recruitment during finger tapping in boys with tourette syndrome

Roessner

Wittfoth

Schmidt‐Samoa

et al. 2011

Human Brain Mapping

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In Tourette syndrome (TS), not only the tics but also the findings on deficits in motor performance indicate motor system alterations. But our knowledge about the pathophysiology of the motor system in TS is still limited. To better understand the neuronal correlates of motor performance in TS, 19 treatment-naïve boys [age 12.5 (SD 1.4) years] with TS without comorbid symptomatology were compared to an age-matched healthy control group [n = 16; age 12.9 (SD 1.6) years] in regard to brain activation during right-hand index finger tapping by means of functional magnetic resonance imaging. Group differences were found mainly in the left (contralateral) precentral gyrus, which was less activated in boys suffering from TS and in caudate nucleus as well as in medial prefrontal cortex, which was more activated compared to healthy boys. These results show that even in the first years after the onset of the disorder, an altered brain network of motor performance is recruited. These alterations in brain regions frequently associated with TS are probably based on functional changes, which are discussed in terms of early compensatory mechanisms of the motor execution network.

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Gilles de la Tourette syndrome and voluntary movement: A functional MRI study

Cited by 23 publications

References 15 publications

Motor-Cortical Interaction in Gilles de la Tourette Syndrome

Motor-Cortical Interaction in Gilles de la Tourette Syndrome

Memory and executive functions in adults with Gilles de la Tourette syndrome and chronic tic disorder

Altered motor network recruitment during finger tapping in boys with tourette syndrome

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