Giant retrosternal goitre causing lung atelectasis

Figueiredo, Ana; Simões‐Pereira, Joana

doi:10.5603/ep.a2022.0043

Cited by 2 publications

(2 citation statements)

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“…A choking sensation exacerbated by the supine position, globus, wheezing, and exercise-induced dyspnea (both mistaken for asthma), or dysphagia are the symptoms most commonly reported by patients, that on the other hand are asymptomatic at presentation in over one-third of cases 5 . Mechanisms of dyspnea are believed to be direct extrinsic tracheal compression, dysfunction of the recurrent laryngeal nerve, and lung atelectasis 24 . Instead, in less than 5 % of cases the clinical presentation of RG may be acute: spontaneous hemorrhagic enlargement of RG may occur during pregnancy 25,26 or for unclear reasons 27,28 , acute asphyxia and cardiac arrest have been described 29,30 , and some authors have hypothesized a direct phrenic nerve compression by the RG as the main cause of these dramatic scenarios 31 .…”

Section: Clinical Presentationmentioning

confidence: 99%

A critical update on the management of retrosternal goiter

Miani,

Locatello,

Bergamin-Bracale

et al. 2023

Preprint

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Background: Retrosternal goiters (RGs) pose several challenges to head and neck surgeons because of the intricate anatomical relationships with major vessels and other mediastinal structures. Methods: A scoping review of the last five years in the PubMed database was conducted and a total of 105 articles were discussed, along with methodological issues and future directions in the research on RGs. Results: The surgical excision of RGs may be accomplished by standard transcervical approach in the vast majority of cases, yet the potential need for a transthoracic approach must be always kept in mind. Great expertise in referral centers is required to maintain an acceptable rate of postoperative complications, and a thorough diagnostic work-up is mandatory. Several non-surgical treatments in addition to mini-invasive approaches have been proposed for RGs. Conclusions: RGs require a multidisciplinary thyroid team in order to eventually minimize the risk of complications and avoid extracervical approaches.

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Section: Clinical Presentationmentioning

confidence: 99%

A critical update on the management of retrosternal goiter

Miani,

Locatello,

Bergamin-Bracale

et al. 2023

Preprint

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“…Its rarity lies in the fact that it typically afflicts elderly patients, with a relatively low incidence rate. Due to its often nonspecific symptoms such as difficulty breathing, swallowing, and the presence of a neck mass, it can easily be misdiagnosed as other conditions like cardiovascular diseases or esophageal cancer, posing significant clinical challenges[ 2 - 4 ]. The significance of this case report lies in providing the medical community with a detailed clinical case and pathological analysis of elderly giant retrosternal thyroid goiter, along with immunohistochemical research data[ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Pathological diagnosis and immunohistochemical analysis of giant retrosternal goiter in the elderly: A case report

Meng,

Wu,

et al. 2024

World J Clin Cases

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BACKGROUND Elderly giant retrosternal thyroid goiter is a rare yet significant medical condition, often presenting clinical symptoms that can be confused with other diseases, posing diagnostic and therapeutic challenges. This study aims to delve into the characteristics and potential mechanisms of this ailment through pathological diagnosis and immunohistochemical analysis, providing clinicians with more precise diagnostic and treatment strategies. CASE SUMMARY A 77-year-old male, was admitted to hospital with the chief complaint of finding a goiter in the semilunar month during physical examination, accompanied by dyspnea. Locally protruding into the superior mediastinum, the adjacent structure was compressed, the trachea was compressed to the right, and the local lumen was slightly narrowed. The patient was diagnosed with giant retrosternal goiter. Considering dyspnea caused by trachea compression, our department planned to perform giant retrosternal thyroidectomy. Immunohistochemical results: Tg (+), TTF-1 (+), Calcitonin (CT) (I), Ki-67 (+, about 20%), CD34 (-). Retrosternal goiter means that more than 50% of the volume of the thyroid gland is below the upper margin of the sternum. As retrosternal goiter disease is a relatively rare disease, once the disease is diagnosed, it should be timely surgical treatment, and the treatment is more difficult, the need for professional medical team for comprehensive treatment. CONCLUSION The imaging manifestations of giant retrosternal goiter are atypical, histomorphology and immunohistochemistry can assist in its diagnosis. This article reviews the relevant literature of giant retrosternal goiter immunohistochemistry and shows that giant retrosternal goiter is positive for Tg, TTF-1, and Ki-67.

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Giant retrosternal goitre causing lung atelectasis

Cited by 2 publications

References 0 publications

A critical update on the management of retrosternal goiter

A critical update on the management of retrosternal goiter

Pathological diagnosis and immunohistochemical analysis of giant retrosternal goiter in the elderly: A case report

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