Giant pilar tumor of the scalp

Casas, J. G.

doi:10.1001/archderm.116.12.1395

Cited by 10 publications

(6 citation statements)

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“…Lesion size is usually <2 cm, but sizes of ≤25 cm have been reported and 90% of the patients are Caucasian (10,11). The current study focused on the clinicopathological features and management of head and neck tricholemmal carcinoma in China.…”

Section: Discussionmentioning

confidence: 99%

Tricholemmal carcinoma of the head and neck region: A report of 15 cases

et al. 2013

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Tricholemmal carcinoma is an extremely rare malignancy of the skin, and its biological behavior and management is controversial. The objective of the present study was to investigate the clinicopathological characteristics and management of tricholemmal carcinoma of the head and neck region. The study analyzed 15 patients with tricholemmal carcinoma. Demographic and clinical data were collected, and features associated with the management and prognosis of tricholemmal carcinoma were analyzed. Two of the 15 patients were lost to follow-up. The results showed that, during the follow-up period, 5 of the 13 available patients succumbed to the causes of recurrence (n=3), neck lymph node metastasis (n=1) and Parkinson’s disease (n=1). No patients developed distant metastasis. The disease-free survival (DFS) and overall survival (OS) were 31.1±7.8 and 32.9±7.4 months (mean ± SE), respectively, and the DFS and OS rates were 69.2 and 61.5%, respectively. In conclusion, the biological behavior of tricholemmal carcinoma is locoregionally aggressive. The recommended management for head and neck tricholemmal carcinoma is radical resection and neck dissection, and post-operative radiotherapy may be considered for high-risk patients.

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Section: Discussionmentioning

confidence: 99%

Tricholemmal carcinoma of the head and neck region: A report of 15 cases

et al. 2013

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“…It usually consists of a solitary lesion and the usual clinical presentation is a subcutaneous cystic nodule that has been present for years and slowly progresses to a large, nodular mass, as a consequence of a history of trauma or chronic inflammation. Proliferating trichilemmal tumors can become large if neglected; a lesion as large as 25cm has been reported 7 ) .…”

Section: Discussionmentioning

confidence: 99%

A Case of Malignant Proliferating Trichilemmoma of the Scalp with Multiple Metastases

Bae

Lee

Kim

et al. 2001

Korean J Intern Med

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We report a case of malignant proliferating trichilemmal tumor showing multiple distant metastases. The patient demonstrated a round mass in the right occipital area for 12 months and the lesion grew rapidly to assume 8×6.5×4cm in diameter, with areas of superficial erosion and crusting within the recent 3 months. The entire lesion was removed with a wide surgical excision. It recurred on the neck area 4 months after excision and the lesion was removed with surgical resection again. There was evidence of multiple metastases on CNS and mediastinal lymph nodes after 6 months. The patient was treated with cisplatin and etoposide combination chemotherapy and a partial response was achieved.

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“…[56] Alternatively, some authors have recently suggested that PTC is a squamous cell carcinoma. [78910] Nevertheless the malignant potential of these tumors is still debated[11] and new strategies for the evaluation of tumor grade are needed. On the other hand, major association between the presence of ki67 and the grade of malignancy has been observed in all tumors which have been studied by ki67 immunostaining.…”

Section: Introductionmentioning

confidence: 99%

Proliferating trichilemmal cyst: The value of ki67 immunostaining

Rangel-Gamboa¹,

Reyes-Castro²,

Domínguez‐Cherit³

et al. 2013

Int J Trichol

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Background:A proliferating trichilemmal cyst (PTC) is an uncommon, rapidly-reproducing cutaneous epithelial cyst, differentiating from the isthmic portion of the outer hair root sheath. It is usually described as a benign tumor, but malignant transformation has been reported and is then denominated as a malignant proliferating trichilemmal tumor. Ki67 immunostaining has been used as a methodology for the evaluation of tumor grade in other tumors, due to its distinctive reaction patterns which exclusively involve proliferating cells.Objectives:(1) To report the incidence of cases of PTCs in a General Hospital during a 12 years period. (2) To determine the expression of ki67 using immunohistochemical staining. (3) To correlate ki67 reaction patterns with clinical prognosis.Materials and Methods:The dermatology department's files during a period of 12 years were reviewed; cases with a diagnosis of PTC were selected, and ki67 immunostaining was done when enough biological material was available.Results:A total of 15 cases with a diagnosis of PTC were identified. In 12 cases, ki67 immunostaining was carried out. In 9 of the 12 cases, ki67 was observed in the basal cells of the cystic epithelium, one case was moderately positive in palisading epithelial cells; in the other two cases ki67 immunostaining was negative. Clinical follow-up was done and revealed that no patient had local recurrence in 5 years after surgical removal of PTC. We therefore consider this immunostaining technique is probably correlated with low recurrence potential.

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Giant pilar tumor of the scalp

Cited by 10 publications

References 0 publications

Tricholemmal carcinoma of the head and neck region: A report of 15 cases

Tricholemmal carcinoma of the head and neck region: A report of 15 cases

A Case of Malignant Proliferating Trichilemmoma of the Scalp with Multiple Metastases

Proliferating trichilemmal cyst: The value of ki67 immunostaining

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