Giant meningioma in a fourteen-month-old infant

Alp, Hızır; Çeviker, Necdet; Baykaner, Kemali; Orbay, Toygun

doi:10.1016/0090-3019(85)90069-2

Cited by 9 publications

(5 citation statements)

References 5 publications

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“…The large size of some CHMs has been mentioned in several series [2,7,48,56], and especially in those including NF pedigrees, implicates NF as a stigma sugges- tive of rapid tumor growth [37]. We found large tumors (>5 cm in diameter) in 50% of the cases in this series without any sign of NF and with good clinical outcome.…”

Section: Tumor Localization and Sizesupporting

confidence: 59%

Meningiomas of the central nervous system occurring below the age of 17: report of 24 cases not associated with neurofibromatosis and review of literature

Amirjamshidi

Mehrazin

Abbassioun

2000

Child's Nervous System

100

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The objective of this work was to gain more insight into the controversial characteristics of meningiomas occurring during childhood and adolescence. Management of meningiomas is an important field in pediatric neurosurgery. Every pediatric neurosurgeon has tried to resolve the problems relating to the clinical characteristics, biological behavior and outcome of this interesting and almost benign pathology, which rarely occurs in the first two decades of life. The records on central nervous system (CNS) tumors held by the two major neurosurgery centers of Tehran Medical University and Arad General Hospital were prospectively collected during last 15 years. Complete medical records are available for all 24 cases, and long-term follow-up was achieved 19 patients. All the cases were diagnosed and treated after the introduction of computed tomographic (CT) scanning. Angiography and magnetic resonance imaging (MRI) were performed as complementary studies in some cases. The sample consisted of 13 girls and 11 boys. The age range at the time of diagnosis varied between 2 and 17 years, with a mean of 9.47 and standard deviation of 3.43. Fifteen patients were below 10 years of age (62.5%), and 9 of them were between 10 and 17 years old (37.5%). The most common presenting symptoms, in declining order of frequency, were headache, epilepsy and focal neurological deficits. Similar cases associated with neurofibromatosis either at the time of presentation with meningioma or during the follow-up period were excluded (5 cases). The size of the presenting tumor was more than 5 cm in diameter in 17 cases. The locations of the lesions, taken as the site of the presumed widest dural base in each case were: spinal, orbital, ethmoidal and sphenoethmoidal in 1 case each, petroclival in 2, and tentorial or supratentorial in 18 patients. The only predisposing factor in this series of childhood meningiomas was whole-axis irradiation for previous malignancy in the case presenting with cervical intradural meningioma. There have been no surgical deaths, and gross total excision of the lesions was achieved in 21 cases. Tumor recurrence was observed during the follow-up period in 6 cases (25%). The follow-up period varied between 2 and 165 months, with a median interval of 130.2 months. This series of pediatric CNS meningiomas comprises almost 1.08% of all meningiomas operated on by the authors during the last 15 years and it also accounts for about 1.1% of all pediatric CNS tumors encountered. This series of patients has certain characteristics regarding sex distribution, unusual size, peculiar localizations, special histological features and benign clinical behavior distinguishing it from other series reported in the literature.

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Section: Tumor Localization and Sizesupporting

confidence: 59%

Meningiomas of the central nervous system occurring below the age of 17: report of 24 cases not associated with neurofibromatosis and review of literature

Amirjamshidi

Mehrazin

Abbassioun

2000

Child's Nervous System

100

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“…As a result, these tumors are relatively rare, and studies on large intracranial meningiomas are limited. The majority of these studies are limited to case reports 6,12,14,15 and small case series 4,5,16 . Prior to this study, only two large series (> 20 cases) evaluated the resectability of large intracranial meningiomas 7,17 .…”

Section: Discussionmentioning

confidence: 99%

Pre-Operative Factors Affecting Resectability of Giant Intracranial Meningiomas

Quiñones‐Hinojosa

Kaprealian

Chaichana

et al. 2009

Can. j. neurol. sci.

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ABSTRACT:Objective: Larger intracranial tumors require extended operating times and may be associated with increased perioperative complications. There are few reports describing the experience of resecting large meningiomas ≥5cm in a variety of locations. As a group, it remains largely unknown whether these relatively rare lesions are amenable to radical resection, and what factors influence their resectability. Methods: Sixty-seven patients undergoing surgery for a large intracranial meningioma (≥5cm in the longest dimension) between 1998 and 2004 were retrospectively reviewed. The surgeries were performed at a single institution University of California at San Francisco. Predictors of resectability were assessed via multivariate logistical regression analysis. Results: Thirty-nine (58%) patients underwent gross total resection (GTR) (Simpson grades I/II). There were no cases of perioperative mortality. At last follow-up, symptoms improved in 39 (58%) patients, remained unchanged in 20 (30%), and were aggravated in 8 (12%). In the multivariate model for all large meningiomas, age>45 years [OR (95%CI) The results indicate that GTR can be achieved in the majority of cases with limited morbidity and mortality, where symptoms will likely improve and recurrences seldom occur. This study may provide useful insights for patients undergoing surgery for large intracranial meningiomas.RÉSUMÉ: Facteurs préopératoires affectant la résécabilité des méningiomes intracrâniens géants. Objectif : La résection des grosses tumeurs intracrâniennes nécessite un temps opératoire prolongé et peut être associée à une augmentation des complications périopératoires. Il existe peu d'articles décrivant l'expérience acquise dans la résection de gros méningiomes de 5 cm ou plus situés dans différents endroits. On ne sait pas encore vraiment si ce type de lésion relativement rare est traitable par résection radicale et quels sont les facteurs qui influencent leur résécabilité. Méthodes : Nous avons révisé les dossiers de 67 patients qui ont subi la résection d'un gros méningiome intracrânien (≥ 5 cm dans sa plus grande dimension) entre 1998 et 2004. La chirurgie a été effectuée dans une seule institution (UCSF). Les éléments qui prédisaient la résécabilité ont été évalués par analyse de régression logistique multivariée. Résultats : Trente-neuf (58%) des patients ont subi une résection totale fruste (RTF) (Simpson grades I/II), sans mortalité périopératoire. Au dernier suivi, les symptômes s'étaient améliorés chez 39 patients (58%) ; ils étaient inchangés chez 20 (30%) et s'étaient aggravés chez 8 (12%). À l'analyse multivariée incluant tous les gros méningiomes, l'âge inférieur à 45 ans (RC 0,127 et IC à 95% de 0,026 à 0,616 ; p = 0,01) et l'atteinte du sinus sagittal supérieur (RC 0,160 et IC à 95% de 0,026 à 0,976 ; p = 0,05) prédisaient négativement une RTF alors qu'il existait une association positive entre l'embolisation préopératoire et la RTF (RC 8,087 et IC à 95% de 1,719 à 38,044 ; p = 0,008). Quant aux méningiomes supratentoriels...

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“…There has been little deviation from these original estimates, with pediatric meningiomas commonly quoted as constituting <2% of all meningiomas and <3% of all childhood brain tumors. Congenital or infantile examples are even rarer, having typically been published as individual case reports (6,7,21,27,29,47,49,59,67,90,96,104,109,112,124,128,141,142,153,171,175,179,190,194,198). Unique aspects within this youngest age group include large tumor size, cyst formation, intraparenchymal origin, high-grade histology, aggressive behavior, and aggressive variants, particularly the clear cell and papillary meningiomas.…”

Section: Meningiomasmentioning

confidence: 99%

Meningeal Tumors of Childhood and Infancy. An Update and Literature Review.

Perry

Dehner

2003

Brain Pathology

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Meningeal derived tumors of the first 2 decades of life are often diagnostically challenging due to the wide morphologic spectrum encountered and the rarity of most individual entities. The 2 most common patterns include the dural/leptomeningeal‐based mass and neoplastic meningitis. Both primary and secondary meningeal presentations may occur, either early or late in the course of various meningothelial, mesenchymal, embryonal, glial, hematopoietic, histiocytic, melanocytic, and inflammatory tumors. As in other areas of pediatric pathology, there are significant differences between this patient cohort and adults, differences which will be emphasized in this review.

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Giant meningioma in a fourteen-month-old infant

Cited by 9 publications

References 5 publications

Meningiomas of the central nervous system occurring below the age of 17: report of 24 cases not associated with neurofibromatosis and review of literature

Meningiomas of the central nervous system occurring below the age of 17: report of 24 cases not associated with neurofibromatosis and review of literature

Pre-Operative Factors Affecting Resectability of Giant Intracranial Meningiomas

Meningeal Tumors of Childhood and Infancy. An Update and Literature Review.

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