Giant Lambl Excrescences

Abstract

A relationship between giant LEs and stroke may be suggested. In patients who have transesophageal echocardiographic findings that are consistent with this diagnosis and recurrent stroke despite antithrombotic therapy and without an alternative explanation for the ischemic symptoms, surgery should be considered in view of these findings.

A Large Lambl’s Excrescence Causing Embolic Stroke in a Young Patient: A Case Report and Review of Literature

“…Histologically, LEs are composed of endocardial-type spindle cells lining a densely hyalinized central core 6 whereas other forms are composed of a single layer of endothelium surrounding copious collagen and elastic fibrils. 7,8,60 We reviewed the literature and found that most LEs exist on left-sided highpressure valves, the ventricular aspect of the aortic valves (Figure 3(B)) and the atrial aspect of the mitral valve, 61 and that most case reports of cerebral embolism had aortic valve LEs (Table 1), similar to our patient.…”

A Large Lambl’s Excrescence Causing Embolic Stroke in a Young Patient: A Case Report and Review of Literature

“…Histologically, LEs are composed of endocardial-type spindle cells lining a densely hyalinized central core 6 whereas other forms are composed of a single layer of endothelium surrounding copious collagen and elastic fibrils. 7,8,60 We reviewed the literature and found that most LEs exist on left-sided highpressure valves, the ventricular aspect of the aortic valves (Figure 3(B)) and the atrial aspect of the mitral valve, 61 and that most case reports of cerebral embolism had aortic valve LEs (Table 1), similar to our patient.…”

Cardiac Papillary Fibroelastoma:A Rare Cause of Isch emic Stroke in the Young

“…Their role in myocardial infarct and sudden death was then suspected and broadly reported in the cardiovascular literature [20]. We found 21 cases [3, 7, 8, 12, 13, 15, 17, 19, 21, 22, 23, 24, 25, 26], 10 males and 11 females, including ours, of patients clinically documented enough with a pathological demonstration of a papillary fibroelastoma discovered after a neurological event: transient ischemic attack (TIA), stroke or retinal ischemia (table 1). The patients were generally asymptomatic without any cardiac signs.…”

The serpentine mitral valve and cerebral embolism

“…The mechanism for embolic events is either that of thrombi forming on the strands which then embolize or it is possible that the valvular strand itself can embolize[2]. Direct visualization of thrombus on a valvular strand have indeed been described before[10]. …”

A Large Lambl’s Excrescence Causing Embolic Stroke in a Young Patient: A Case Report and Review of Literature

“…Histologically, LEs are composed of endocardial-type spindle cells lining a densely hyalinized central core 6 whereas other forms are composed of a single layer of endothelium surrounding copious collagen and elastic fibrils. 7,8,60 We reviewed the literature and found that most LEs exist on left-sided highpressure valves, the ventricular aspect of the aortic valves (Figure 3(B)) and the atrial aspect of the mitral valve, 61 and that most case reports of cerebral embolism had aortic valve LEs (Table 1), similar to our patient.…”

Cardiac Papillary Fibroelastoma:A Rare Cause of Isch emic Stroke in the Young

“…Their role in myocardial infarct and sudden death was then suspected and broadly reported in the cardiovascular literature [20]. We found 21 cases [3, 7, 8, 12, 13, 15, 17, 19, 21, 22, 23, 24, 25, 26], 10 males and 11 females, including ours, of patients clinically documented enough with a pathological demonstration of a papillary fibroelastoma discovered after a neurological event: transient ischemic attack (TIA), stroke or retinal ischemia (table 1). The patients were generally asymptomatic without any cardiac signs.…”

The serpentine mitral valve and cerebral embolism

“…The mechanism for embolic events is either that of thrombi forming on the strands which then embolize or it is possible that the valvular strand itself can embolize[2]. Direct visualization of thrombus on a valvular strand have indeed been described before[10]. …”

A Large Lambl’s Excrescence Causing Embolic Stroke in a Young Patient: A Case Report and Review of Literature

“…Histologically, LEs are composed of endocardial-type spindle cells lining a densely hyalinized central core 6 whereas other forms are composed of a single layer of endothelium surrounding copious collagen and elastic fibrils. 7,8,60 We reviewed the literature and found that most LEs exist on left-sided highpressure valves, the ventricular aspect of the aortic valves (Figure 3(B)) and the atrial aspect of the mitral valve, 61 and that most case reports of cerebral embolism had aortic valve LEs (Table 1), similar to our patient.…”

Cardiac Papillary Fibroelastoma:A Rare Cause of Isch emic Stroke in the Young

“…Their role in myocardial infarct and sudden death was then suspected and broadly reported in the cardiovascular literature [20]. We found 21 cases [3, 7, 8, 12, 13, 15, 17, 19, 21, 22, 23, 24, 25, 26], 10 males and 11 females, including ours, of patients clinically documented enough with a pathological demonstration of a papillary fibroelastoma discovered after a neurological event: transient ischemic attack (TIA), stroke or retinal ischemia (table 1). The patients were generally asymptomatic without any cardiac signs.…”

The serpentine mitral valve and cerebral embolism

“…The mechanism for embolic events is either that of thrombi forming on the strands which then embolize or it is possible that the valvular strand itself can embolize[2]. Direct visualization of thrombus on a valvular strand have indeed been described before[10]. …”