Giant Keratoacanthoma

KALLOS, ANDREW

doi:10.1001/archderm.1958.01560080067012

Cited by 10 publications

(3 citation statements)

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“…A multi‐nodular KA with central clearing was recently described in which the size of the lesion reached 20 × 14 cm and showed no evidence of arrest of growth 7 . Another variant is the giant KA, lesions over 2 to 3 cm in diameter 8 . The vast majority of patients with this type are healthy, and show no clinical evidence of immune system compromise.…”

Section: Introductionmentioning

confidence: 99%

Eruptive Keratoacanthoma en Plaque in an Immunosuppressed Patient

Washington

Mikhail²

1987

The Journal of Dermatologic Surgery and Oncology

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Immunosuppressive therapy predisposes to the development of a variety of neoplasms. A 63-year-old man developed multiple eruptive epithelial tumors 15 years after renal transplantation. The tumors included what had been diagnosed as squamous cell carcinomas, Bowen's disease, and solitary and eruptive keratoacanthomas. In addition, he developed a large plaque studded with small nodules that had the histologic features of keratoacanthoma. To our knowledge, this is the first example of acquired eruptive keratoacanthoma forming a large plaque.

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Section: Introductionmentioning

confidence: 99%

Eruptive Keratoacanthoma en Plaque in an Immunosuppressed Patient

Washington

Mikhail²

1987

The Journal of Dermatologic Surgery and Oncology

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“…A search in the Pubmed database revealed 47 cases since 1958, when the first case report on the head and neck giant KA was first published, presenting a 57-year-old male patient with a lesion in the eyebrow region. 9 KAs in the head and neck region presenting more than 2 cm in diameter are rare and denominated giant KA. 1,[10][11] In our study, we observed that the head and neck giant KA cur-rently presents a mean size of 3.93 cm in diameter.…”

Section: Discussionmentioning

confidence: 99%

Head and neck giant keratoacanthoma: a case report

Damasceno¹,

Neto²,

Vieira³

et al. 2018

j.rpemd

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Keratoacanthoma is a low-grade tumor originated from the pilosebaceous glands that nearly resembles squamous cell carcinoma under histopathological analysis. Giant keratoacanthoma is a rare subtype with a size exceeding 2 cm, with a high aggressiveness potential. Head and neck giant keratoacanthomas are uncommon and mainly affect male patients with a mean age of 59.1 years old, usually affecting the nose. Excision of the lesion is the preferred treatment for giant keratoacanthoma. The aim of this study is to analyze the clinicopathological characteristics of head and neck giant keratoacanthoma by reviewing the previously published English literature and reporting one new case of a rare lesion affecting the lower lip.

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“…KA usually attain their mature size within 6-8 weeks of clinical onset. Then, the most likely course is slow involution, although some KA can be locally aggressive (2,3).…”

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confidence: 99%

Quantitation of S100 protein‐positive cells in inflamed and non‐inflamed keratoacanthoma and squamous cell carcinoma

et al. 1988

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Langerhans cells (LC) were identified and quantitated in non-inflamed keratoacanthoma (KA), inflamed KA, non-inflamed squamous cell carcinoma (SCC), and inflamed SCC, by their content of S100 protein. The number of LCs per high-power field was markedly increased in inflamed KA when compared to the other groups. Using similar methods on frozen sections, the expression of HLA-DR was identified on keratinocytes in KA in areas of inflammation but not in other lesions under study. We hypothesize that increased numbers of LCs in inflamed KA are part of the process which results in tumor regression.

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Giant Keratoacanthoma

Cited by 10 publications

References 0 publications

Eruptive Keratoacanthoma en Plaque in an Immunosuppressed Patient

Eruptive Keratoacanthoma en Plaque in an Immunosuppressed Patient

Head and neck giant keratoacanthoma: a case report

Quantitation of S100 protein‐positive cells in inflamed and non‐inflamed keratoacanthoma and squamous cell carcinoma

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