Giant Intrathoracic Mass in a Young Woman With Acute Kidney Injury

Matyjek, Anna; Stanowska, Olga; Talarek, Lukasz; Wągrodzki, Michał; Olszewska, Katarzyna; Castaneda-Wysocka, Patrycja; Owczarek, Joanna; Szołkowska, Małgorzata; Prochorec‐Sobieszek, Monika; Rymarz, Aleksandra; Niemczyk, Stanisław

doi:10.1016/j.chest.2021.03.050

Cited by 3 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…92 In contrast, lipofibroadenoma can cause autoimmune disorders while few immature T cells accompany the cord-like thymic epithelium. 93 This supports the idea that the presence of immature T cells alone is insufficient for developing TAMG, but rather the nature of neoplastic epithelial cells and/or tumor microenvironment is involved in the pathogenesis.…”

Section: Disease-relevant Phenotypes In Tetssupporting

confidence: 75%

Histogenetic and disease‐relevant phenotypes in thymic epithelial tumors (TETs): The potential significance for future TET classification

Yamada

2023

Pathology International

View full text Add to dashboard Cite

Thymic epithelial tumors (TETs) encompass morphologically various subtypes. Thus, it would be meaningful to explore the expression phenotypes that delineate each TET subtype or overarching multiple subtypes. If these profiles are related to thymic physiology, they will improve our biological understanding of TETs and may contribute to the establishment of a more rational TET classification. Against this background, pathologists have attempted to identify histogenetic features in TETs for a long time. As part of this work, our group has reported several TET expression profiles that are histotype‐dependent and related to the nature of thymic epithelial cells (TECs). For example, we found that beta5t, a constituent of thymoproteasome unique to cortical TECs, is expressed mainly in type B thymomas, for which the nomenclature of cortical thymoma was once considered. Another example is the discovery that most thymic carcinomas, especially thymic squamous cell carcinomas, exhibit expression profiles similar to tuft cells, a recently discovered special type of medullary TEC. This review outlines the currently reported histogenetic phenotypes of TETs, including those related to thymoma‐associated myasthenia gravis, summarizes their genetic signatures, and provides a perspective for the future direction of TET classification.

show abstract

Section: Disease-relevant Phenotypes In Tetssupporting

confidence: 75%

Histogenetic and disease‐relevant phenotypes in thymic epithelial tumors (TETs): The potential significance for future TET classification

Yamada

2023

Pathology International

View full text Add to dashboard Cite

show abstract

“…In the case presented here we did not identify genetic aberrations, specifically no HMGA -2 mutation was found, as described recently in thymolipoma, nor were CNVs documented. In a single recently described LFA case no fusion transcripts were detected ( 13 ), taken together with our case, there are currently no features which support a neoplastic process.…”

Section: Discussionsupporting

confidence: 40%

“…The follow-up of all reported cases after surgical removal of the LFA is favorable, no recurrences have been reported and patients made a good recovery. While the patient described in the report by Matyjek and co-workers made an initial good recovery from the operative procedure to remove a large LFA, she did suffer progressive anti neutrophil cytoplasmic antibody (ANCA)-vasculitis associated renal failure ( 13 ). Although it was suggested that the vasculitis may have been associated with the LFA given the co-occurrence of two rare diseases, this may be contested as the ANCA-associated vasculitis progressed after removal of the LFA.…”

Section: Discussionmentioning

confidence: 99%

Asymptomatic lipofibroadenoma in a 17-year-old male: a case report and literature review of a rare entity

Bakker¹,

Vermeulen²,

Ven³

et al. 2023

Mediastinum

View full text Add to dashboard Cite

Background The most common thymic tumours, thymomas, are derived from thymic epithelium and are generally low-grade neoplasm. Frankly malignant tumours, thymic carcinomas are rarer still. Exceedingly rare thymic tumours contain a mesenchymal tissue component such as fibrous connective tissue and/or mature fat. Lipofibroadenoma (LFA) is a very rare mixed epithelial-mesenchymal thymic tumour, included in the category of thymic epithelial tumors. LFA in addition to a mature adipocytic component, contains variable epithelial and mesenchymal tissue components. Owing to the presence of an epithelial component in LFA, this entity, in contrast to thymolipoma, is included in the World Health Organization (WHO) category of thymic epithelial neoplasm. Currently only 12 LFA cases have been described. The 12 previously reported cases all behaved in a benign fashion, although four cases were associated with a conventional type of thymoma. We here present a new, 13th, case of LFA. Case Description The LFA was discovered incidentally in a previously healthy 17-year-old male after investigations for suspected pneumonia. On imaging a mass was discovered in the anterior mediastinum which was subsequently surgically removed. The resected tumour was extensively investigated, including the first instance of full molecular analysis of this rare entity and all available literature on LFA was sourced to provide a comprehensive overview. The histology of this LFA was similar to previously described cases. No gene mutations or rearrangements were identified. The patient made an uneventful recovery and after 13 months of follow-up remained well. Conclusions An additional, 13th case of LFA is presented. Based on the available literature it appears that LFA may be considered a benign composite thymic tumour, although the combination of an additional conventional thymoma component may warrant closer follow-up.

show abstract

Unusual thymoma subtypes

Bakker¹

2023

Diagnostic Histopathology

View full text Add to dashboard Cite

Giant Intrathoracic Mass in a Young Woman With Acute Kidney Injury

Cited by 3 publications

References 9 publications

Histogenetic and disease‐relevant phenotypes in thymic epithelial tumors (TETs): The potential significance for future TET classification

Histogenetic and disease‐relevant phenotypes in thymic epithelial tumors (TETs): The potential significance for future TET classification

Asymptomatic lipofibroadenoma in a 17-year-old male: a case report and literature review of a rare entity

Unusual thymoma subtypes

Contact Info

Product

Resources

About