Giant Condylomata Acuminata of Buschke and Lowenstein

Dermatopathologic effects of taxane therapy

“…As a result, podophyllin-treated warts may be misdiagnosed as SCC. 17 It has long been taught that biopsy specimens of warts treated with podophyllin may simulate SCC; accordingly, dermatologists may avoid such procedures whenever possible or at least alert their pathologists to the hazard of this pharmacologic artifact. However, dermatologists, when performing biopsies, may not always be aware of a patient's recent treatment with taxane drugs, nor always be cognizant of these agents' pertinent cytotoxic effects.…”

Buschke-Lowenstein's tumour presenting with urinary fistula.

“…Indeed, deeper infiltration, destruction and fistula formation, but for the young age of the patient, prompts one to suspect a malignant process and that an urgent histopatho-N logical examination will be needed. The lesion is generally found to be benign, although malignant transformations are known to occur (Machacek and Weakley, 1960;Siegel, 1962). In elderly patients, a number of biopsies may have to be taken to determine the true nature of the lesion (Oranje et al, 1976).…”

“…In elderly patients, a number of biopsies may have to be taken to determine the true nature of the lesion (Oranje et al, 1976). Podophyllin, although a useful topical remedy for ordinarycondyloma acuminata, has repeatedlyproved valueless for treating Buschke-Lowenstein's tumour (Machacek and Weakley, 1960;Dawson et al, 1965;Knoblich and Failing, 1967;MacCarron and Carlton, 1970;Netto et al, 1976). Such lesions, instead, are often subjected to electrocoagulation or surgical excision.…”

Problematik der Diagnose papillomatöser Geschwülste an der Vulva

“…Über maligne Entartungen von jahrelang persistierenden und rezidivie renden Riesenkondylomen der Vulva liegen einige Berichte vor [1,5,7,10,11,15,16,18,20,22,[25][26][27]. Sie halten allerdings einer strengen Überprüfung nicht immer stand, weil es sich bei den beschriebenen Tumo ren zum Teil um kondylomartige Karzinome oder um Condylomata acuminata handelt, die neben einem Vulvakarzinom entstanden sind.…”

“…Im Gegensatz zu seinem klinisch-biologisch aggressiven Verhalten fehlen beim Buschke-Löwenstein-Tumor die histologischen Zeichen der epithe lialen Atypie. Allerdings kann dieser Tumor, der destruierend und pene trierend wächst, auch echte Plattenepithelkarzinome entwickeln [4,8,9,21,22].…”