Giant cell tumour of bone around the knee: a systematic review of the functional and oncological outcomes

Brito, Joaquim Soares do; Spranger, André; Almeida, Paulo; Portela, José Luís Camaño; Barrientos-Ruiz, Irene

doi:10.1302/2058-5241.6.200154

Cited by 4 publications

(5 citation statements)

References 41 publications

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“…GCTB typically affects the meta-epiphysis of long bones, most commonly the distal femur and proximal tibia, but it can arise anywhere throughout the skeleton. The peak of incidence is between 20 and 40 years of age and no gender-based predilection has been observed [13]. The principal treatment approach of GCTB is surgery, which generally includes extensive curettage or en-bloc resection.…”

Section: Gctb: Natural History and Therapeutic Approachesmentioning

confidence: 99%

Malignant Transformation of Giant Cell Tumour of Bone: A Review of Literature and the Experience of a Referral Centre

Vari

Riva

Onesti

et al. 2022

IJMS

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Giant cell tumour of bone (GCTB) is a benign, locally aggressive primary bone neoplasm that represents 5% of all bone tumours. The principal treatment approach is surgery. Although generally GCTB is considered only a locally aggressive disease, it can metastasise, and lung metastases occur in 1–9% of patients. To date, only the use of denosumab has been approved as medical treatment for GCTB. Even more rarely, GCTB undergoes sarcomatous transformation into a malignant tumour (4% of all GCTB), but history of this malignant transformation is unclear and unpredictable. Considering the rarity of the event, the data in the literature are few. In this review, we summarise published data of GCTB malignant transformation and we analyse three cases of malignant transformation of GCTB, evaluating histopathology, genetics, and radiological aspects. Despite the rarity of this event, we conclude that a strict follow up is recommended to detect early malignant transformation.

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Section: Gctb: Natural History and Therapeutic Approachesmentioning

confidence: 99%

Malignant Transformation of Giant Cell Tumour of Bone: A Review of Literature and the Experience of a Referral Centre

Vari

Riva

Onesti

et al. 2022

IJMS

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“…GCT is a benign tumor that typically manifests in middle-aged or older individuals, with a slight predilection for females [3]. While the knee joint is the most common site for these tumors, accounting for over half of all cases, tumors affecting the chest wall are rare [4]. Specifically, GCTs occurring in the rib are even less common, with reported frequencies of less than 1% [5].…”

Section: Introductionmentioning

confidence: 99%

Giant Cell Tumor of the Anterior Arc of the Rib: A Case Report

Srinivas,

Nichkaode,

Sharma

et al. 2024

Cureus

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Tumors that develop on the chest wall are usually rare. This case report highlights a rare occurrence of a giant cell tumor originating from the anterior arch of the fourth rib. The patient, a 21-year-old male, presented with a bulging mass that had been gradually increasing in size over an eight-month period, reaching dimensions of 12 x 8 cm. Despite the noticeable swelling, the patient reported no associated pain or discomfort and denied any history of weight loss or trauma. The absence of chest pain or cardiovascular symptoms distinguished this case from other chest wall pathologies. This report underscores the importance of considering rare entities such as giant cell tumors in the differential diagnosis of chest wall masses, especially in cases where clinical presentation and patient history do not align with more common conditions.

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“…It is generally accepted that LR is precipitated by the postoperative residual tumor tissue, which might be present either in the remaining non-resected bone or surrounding soft tissues [ 12 ]. The EBR is associated with decreased relapse rate compared to IC due to the aggressive and extensive debridement of the pathological bone tissue [ 13 ]. However, the IC is preferable, as EBR has been associated with poor functional results [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Treatment of Recurrent Giant Cell Tumor of Bones: A Systematic Review

Pitsilos

Givissis

Papadopoulos

et al. 2023

Cancers

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The giant cell tumor of bones (GCTB) is a benign bone tumor with high postoperative recurrence potential. No specific treatment protocol has been developed to date in case of tumor recurrence, and the kind of re-operative surgery depends upon the surgeon’s preferences. The aim of this systematic review is to determine the second recurrence rate and the respective functional results of the available treatment options applied to recurrent GCTB. Medline/PubMed and Scopus were searched to identify articles published until March 2023. Twelve studies fulfilled the inclusion criteria, comprising 458 patients suffering from recurrent GCTB. The overall incidence of second recurrence was 20.5%, at a mean interval of 28.8 months after the first surgery, and it was more evident after intralesional curettage (IC) surgery than en-bloc resection (EBR) (p = 0.012). In the IC group of patients, the second recurrence rate was lower and the functional outcome was greater when polymethylmethacrylate cement (PMMAc) was used as an adjuvant instead of bone grafting (p < 0.001 for both parameters). Reconstruction of the created bone defect after EBR with a structural allograft provided a better outcome than prosthesis (p = 0.028). According to this systematic review, EBR (first choice) and IC with PMMAc (second choice) are the best treatment options for recurrent GCTB.

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Giant cell tumour of bone around the knee: a systematic review of the functional and oncological outcomes

Cited by 4 publications

References 41 publications

Malignant Transformation of Giant Cell Tumour of Bone: A Review of Literature and the Experience of a Referral Centre

Malignant Transformation of Giant Cell Tumour of Bone: A Review of Literature and the Experience of a Referral Centre

Giant Cell Tumor of the Anterior Arc of the Rib: A Case Report

Treatment of Recurrent Giant Cell Tumor of Bones: A Systematic Review

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