Giant Cell Tumor of the Skull: Case Report

Henderson, Bruce T. H.; Whitwell, Helen

doi:10.1227/00006123-198807000-00024

Cited by 17 publications

(18 citation statements)

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“…2,3,12,15 Lung, lymph node, mediastinal, skin, scalp, and pelvis metastasis are observed in 2% of the patients, and lung metastases are the most frequent. 11,17 The current study did not reveal metastasis in the lungs or other organs.…”

Section: Discussioncontrasting

confidence: 49%

“…6 Giant cell tumor is most commonly seen between 30 and 50 years of age, and its incidence is slightly higher in women. 2,11 In the current study, the researchers believe that GCT originated from the posterior of the temporomandibular joint and extended to the temporal and sphenoid bones. In addition, the researchers believe that this case is particularly interesting because of the large GCT diameter, symptoms being noticed at a later stage, and the emergence of the condition with otologic symptoms in particular.…”

Section: Discussionmentioning

confidence: 55%

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Giant Cell Tumor of Bone Involving the Temporomandibular Joint and Temporal Bone

Akyiğit¹,

Karlıdağ²,

Sakallıoğlu³

et al. 2014

Journal of Craniofacial Surgery

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Giant cell tumor is a primary bone tumor that usually originates from the epiphysis of the long bones and is rarely seen in the cranial region. Most frequently, the tumor develops in the sphenoid and temporal bones in the middle cranial fossa. Giant cell tumor generally shows diversity with respect to benignity, local invasiveness, and histology. Although surgical excision with negative surgical margin may lead to cure, adjuvant radiotherapy is still debated. The patient was admitted with a humming in the left ear and hearing loss. After radiologic examination, a mass with temporomandibular joint involvement as well as temporal and sphenoid bone localization was detected. The patient was diagnosed with giant cell tumor after a biopsy specimen was taken from the mass extending to the middle ear and destroying the temporomandibular joint. The current study reviewed the patient's clinical features, diagnosis, and treatment in light of the literature.

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Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 55%

Giant Cell Tumor of Bone Involving the Temporomandibular Joint and Temporal Bone

Akyiğit¹,

Karlıdağ²,

Sakallıoğlu³

et al. 2014

Journal of Craniofacial Surgery

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“…GCTs involving the cranial vault (18 cases) are much rarer, and sometimes occur in association with Paget's disease. 1,6,7,[9][10][11][25][26][27][28][29][30] The tumor occurs most frequently between the second and fourth decades of life, with a mild female preponderance (56% of reported cases). The age distribution, with a mean age of 32.6 years in our review, was generally older for GCTs compared with tumors at other sites.…”

Section: Discussionmentioning

confidence: 99%

“…37,45 GCTs are described in the literature as benign neoplasms with a hypervascularized blood supply. 27 All reports in the literature that present angiographic data for cases of GCT indicate that the tumors are richly vascularized via the internal or external carotid artery. 3,11,13,22,26,27,31,41,45,47,48 Aneurysmal bone cysts are considered to be the result of a trauma-or tumor-induced anomalous vascular process.…”

Section: Discussionmentioning

confidence: 99%

“…27 All reports in the literature that present angiographic data for cases of GCT indicate that the tumors are richly vascularized via the internal or external carotid artery. 3,11,13,22,26,27,31,41,45,47,48 Aneurysmal bone cysts are considered to be the result of a trauma-or tumor-induced anomalous vascular process. 33 However, the secondary features of the aneurysmal bone cyst change in our case may support a relationship with the prior hemorrhage and reparative reaction in the hypervascularized tumor.…”

Section: Discussionmentioning

confidence: 99%

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Giant cell tumor of the temporal bone with intratumoral hemorrhage

Matsushige

Nakaoka

Yahara

et al. 2008

Journal of Clinical Neuroscience

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Giant cell tumor of the skull

Bertoni

Unni

Beabout

et al. 1992

Cancer

118

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Background. Most giant cell tumors (GCT) occur at the ends of long bones. There is little information about GCT of the skull bones. Methods. The authors reviewed the Mayo Clinic files, which contained 546 cases of GCT, and their own consultation files, which contained approximately 1500 cases. Results. Eleven tumors occurred in the sphenoid bone with extension to the surrounding bones and structures in 8 patients. One tumor (in Pagets disease) occurred in the frontal bone, one tumor was in the occipital bone, and one tumor was in the temporal bone. There were 4 men and 11 women whose ages ranged from 8 to 78 years, with a mean of 36.5 years. Radiographic findings were not suggestive of a specific diagnosis, although the features were those of an aggressive lesion. Histologically, the tumors had features typical of GCT. However, a prominent spindle cell component was seen in five tumors. The initial treatment in all patients but one was intralesional excision that was as complete as possible. The last patient had a wide excision and had soft tissue recurrence at 1 year. This was excised and she was free of disease at 2.7 years. Three patients died, one in the immediate postoperative period and the other two at 1.6 and 4 years with progression of tumor. One patient had postoperative radiation therapy and was without evidence of disease for 2 years when he was lost to follow‐up. The remaining 10 patients all had postoperative radiation therapy; 6 patients were alive without disease from 4 to 34 years. However, one of these six patients had a recurrence that was treated surgically with additional radiation. Four patients were alive with tumor from 2.1 to 26 years at the time of this report. Conclusions. GCT of the skull bones is rare but should be distinguished from giant cell reparative granuloma because of the tendency for progression. Surgical ablation (as complete as possible) and postoperative radiation therapy seem to be the treatment of choice for GCT of the skull bones.

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Giant Cell Tumor of the Skull: Case Report

Abstract: The case of a 16-year-old girl with giant cell tumor involving the occipital bone is described. The radiological and pathological findings are detailed, followed by a discussion of the literature.

Cited by 17 publications

References 0 publications

Giant Cell Tumor of Bone Involving the Temporomandibular Joint and Temporal Bone

Giant Cell Tumor of Bone Involving the Temporomandibular Joint and Temporal Bone

Giant cell tumor of the temporal bone with intratumoral hemorrhage

Giant cell tumor of the skull

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