Giant Cell Tumor of Bone Involving the Temporomandibular Joint and Temporal Bone

Abstract

Giant cell tumor is a primary bone tumor that usually originates from the epiphysis of the long bones and is rarely seen in the cranial region. Most frequently, the tumor develops in the sphenoid and temporal bones in the middle cranial fossa. Giant cell tumor generally shows diversity with respect to benignity, local invasiveness, and histology. Although surgical excision with negative surgical margin may lead to cure, adjuvant radiotherapy is still debated. The patient was admitted with a humming in the left ear and hearing loss. After radiologic examination, a mass with temporomandibular joint involvement as well as temporal and sphenoid bone localization was detected. The patient was diagnosed with giant cell tumor after a biopsy specimen was taken from the mass extending to the middle ear and destroying the temporomandibular joint. The current study reviewed the patient's clinical features, diagnosis, and treatment in light of the literature.

A rare tumor of clivus masquerading as pituitary adenoma

“…Magnetic resonance (MR) images generally demonstrate signal isointensity on T1-weighted images and signal hypointensity on both T2-and diffusion-weighted images. [5] In the present review of the literature, the tumors were either expansile or lytic lesions. MRI findings 1].…”

“…Few studies have implicated the role of radiation therapy in the sarcomatoid transformation of these tumors. [5] Among the cases reported in the literature, two patients succumbed to metastatic GCT of the clivus. [6,7] In the case reports by Scotto di Carlo et al, one patient had an aggressive tumor which recurred after 1 month of the first surgery.…”

A single-center experience with giant cell tumors of sphenoid bone and clivus

“…14 The differential diagnosis of GCT includes primary aneurysmal bone cyst, Langerhans cell histiocytosis, chondroblastoma, central giant cell reparative granuloma (GCG), brown tumor of hyperparathyroidism, fibrous dysplasia, and cherubism. 2,4,15,16 Brown tumor is excluded from diagnosis based on normal parathormone and calcium levels. The difference between GCTs and GCGs is in debate.…”

Cytology of a temporal swelling in a young adult with unilateral conductive hearing loss

“…Central giant‐cell granuloma/giant‐cell reparative granuloma is a non‐neoplastic lesion, mostly seen in females, involving mandible or maxilla. It arises as a result of trauma, which leads to intraosseous haemorrhage, as opposed to GCTs, which are believed to arise from the undifferentiated mesenchymal cells of bone marrow 4 . Giant‐cell reparative granuloma tends to recur less frequently than GCTs.…”