Ghrelin Levels in Gastric Mucosa before and after Eradication of Helicobacter pylori

Choe, Yon Ho; Lee, Jee Hyun; Lee, Hae Jeong; Paik, Kyung Hoon; Jin, Dong Kyu; Song, Sang Yong; Lee, Jun Haeng

doi:10.5009/gnl.2007.1.2.132

Cited by 14 publications

(15 citation statements)

References 25 publications

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“…It has been demonstrated that central ghrelin administration inhibits gastric acid secretion, but that peripheral ghrelin administration does not modify gastric acid secretion in rats. Thus, the possibility exists that ghrelin and H. pylori infection may be associated (Choe et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Possible association of ghrelin/obestatin balance with cardiometabolic risk in obese subjects with Helicobacter pylori

Ibrahim

Eldeeb

Salama

et al. 2018

Endocrine Regulations

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Section: Discussionmentioning

confidence: 99%

Possible association of ghrelin/obestatin balance with cardiometabolic risk in obese subjects with Helicobacter pylori

Ibrahim

Eldeeb

Salama

et al. 2018

Endocrine Regulations

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“…Due to its intimate relationship with the gastric epithelium, H . pylori , the dominant member of the gastric microbiota, has the potential to affect the regulation of normal energy homeostasis of humans [ 8 – 10 , 42 – 45 ].…”

Section: Discussionmentioning

confidence: 99%

Changes in Metabolic Hormones in Malaysian Young Adults following Helicobacter pylori Eradication

et al. 2015

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BackgroundMore than half of the world’s adults carry Helicobacter pylori. The eradication of H. pylori may affect the regulation of human metabolic hormones. The aim of this study was to evaluate the effect of H. pylori eradication on meal-associated changes in appetite-controlled insulinotropic and digestive hormones, and to assess post-eradication changes in body mass index as part of a currently on-going multicentre ESSAY (Eradication Study in Stable Adults/Youths) study.MethodsWe enrolled 29 H. pylori-positive young adult (18–30 year-old) volunteer subjects to evaluate the effect of H. pylori eradication on meal-associated changes on eight gastrointestinal hormones, using a multiplex bead assay. Changes in body mass index and anthropometric measurements were recorded, pre- and post-eradication therapy.ResultsPre-prandial active amylin, total peptide YY (PYY) and pancreatic polypeptide (PP) levels were significantly elevated 12 months post-eradication compared with baseline (n = 18; Wilcoxon's signed rank test, p<0.05). Four of the post-prandial gut metabolic hormones levels (GLP-1, total PYY, active amylin, PP) were significantly higher 12 months post-eradication compared to baseline (n = 18; p<0.05). Following H. pylori eradication, the BMI and anthropometric values did not significantly change.ConclusionsOur study indicates that H. pylori eradication was associated with long-term disturbance in three hormones (active amylin, PP and total PYY) both pre- and post-prandially and one hormone (GLP-1) post-prandially. Longer post-eradication monitoring is needed to investigate the long-term impact of the observed hormonal changes on metabolic homeostasis.

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“…Increased plasma and gastric mucosal ghrelin levels after H. pylori eradication were also shown by Deng et al [103] in 50 children with H. pylori-associated functional dyspepsia. However, a study reported by Choe et al [109] failed to show a relationship between H. pylori infection and stomach mucosal ghrelin levels, with no effect of eradication therapy. It should be noted that a greater BMI and corpus predominant gastritis are recognized as independent risk factors for eradication failure [110] .…”

Section: Weight Controlmentioning

confidence: 95%

Brain-gut axis in the pathogenesis ofHelicobacter pyloriinfection

Budzyński¹

2014

WJG

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Helicobacter pylori (H. pylori) infection is the main pathogenic factor for upper digestive tract organic diseases. In addition to direct cytotoxic and proinflammatory effects, H. pylori infection may also induce abnormalities indirectly by affecting the brain-gut axis, similar to other microorganisms present in the alimentary tract. The brain-gut axis integrates the central, peripheral, enteric and autonomic nervous systems, as well as the endocrine and immunological systems, with gastrointestinal functions and environmental stimuli, including gastric and intestinal microbiota. The bidirectional relationship between H. pylori infection and the brain-gut axis influences both the contagion process and the host's neuroendocrine-immunological reaction to it, resulting in alterations in cognitive functions, food intake and appetite, immunological response, and modification of symptom sensitivity thresholds. Furthermore, disturbances in the upper and lower digestive tract permeability, motility and secretion can occur, mainly as a form of irritable bowel syndrome. Many of these abnormalities disappear following H. pylori eradication. H. pylori may have direct neurotoxic effects that lead to alteration of the brain-gut axis through the activation of neurogenic inflammatory processes, or by microelement deficiency secondary to functional and morphological changes in the digestive tract. In digestive tissue, H. pylori can alter signaling in the brain-gut axis by mast cells, the main brain-gut axis effector, as H. pylori infection is associated with decreased mast cell infiltration in the digestive tract. Nevertheless, unequivocal data concerning the direct and immediate effect of H. pylori infection on the brain-gut axis are still lacking. Therefore, further studies evaluating the clinical importance of these host-bacteria interactions will improve our understanding of H. pylori infection pathophysiology and suggest new therapeutic approaches.

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Ghrelin Levels in Gastric Mucosa before and after Eradication of Helicobacter pylori

Abstract: These results show that H. pylori infection has no effect on stomach ghrelin levels and that eradication therapy does not influence plasma or tissue ghrelin levels.

Cited by 14 publications

References 25 publications

Possible association of ghrelin/obestatin balance with cardiometabolic risk in obese subjects with Helicobacter pylori

Possible association of ghrelin/obestatin balance with cardiometabolic risk in obese subjects with Helicobacter pylori

Changes in Metabolic Hormones in Malaysian Young Adults following Helicobacter pylori Eradication

Brain-gut axis in the pathogenesis ofHelicobacter pyloriinfection

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