Ghrelin and Obestatin Levels in Severely Obese Women Before and After Weight Loss After Roux-en-Y Gastric Bypass Surgery

Roth, Christian; Reinehr, Thomas; Schernthaner, G.; Kopp, Hans Peter; Kriwanek, Stefan; Schernthaner, Guntram

doi:10.1007/s11695-008-9568-x

Cited by 62 publications

(42 citation statements)

References 40 publications

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“…Many studies have shown gastric bypass operations to be associated with significant reduction of ghrelin levels (Cummings et al, 2002a;Geloneze et al, 2003;Lin et al, 2004;Roth et al, 2009;Stylopoulos et al, 2005;Suzuki et al, 2005). In addition, the normal, meal-related fluctuation and the diurnal rhythm of ghrelin level was found to be absent after gastric bypass surgery (Cummings et al, 2002a).…”

Section: Ghrelin and Bariatric Surgerymentioning

confidence: 99%

Ghrelin in obesity and endocrine diseases

Scerif

Goldstone

Korbonits

2011

Molecular and Cellular Endocrinology

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Section: Ghrelin and Bariatric Surgerymentioning

confidence: 99%

Ghrelin in obesity and endocrine diseases

Scerif

Goldstone

Korbonits

2011

Molecular and Cellular Endocrinology

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“…Haider and colleagues 149 showed that obestatin is lower in obese patients compared with lean controls and is increased 6 months after AGB. In contrast, Roth and associates 126 found that obestatin levels did not change 2 years after RYGB in spite of the massive weight loss of 62.5% EWL.…”

Section: Other Hormonesmentioning

confidence: 86%

Mechanisms Responsible for Excess Weight Loss after Bariatric Surgery

Ionut

Bergman

2011

J Diabetes Sci Technol

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Obesity has increased alarmingly in the United States and is increasing in many countries of the world. Because obesity is an important risk factor for type 2 diabetes and other chronic diseases, it is important to develop approaches to counter the rapid increase in adiposity. One approach is bariatric surgery, the most successful clinical intervention known for treating obesity. Surgery can result in impressive weight loss and improvement of obesity-related comorbidities. Yet the mechanisms responsible for this remarkable effect of surgery remain controversial. It is now clear that caloric restriction, per se, does not explain all the reduction in stored fat mass after surgery. A number of gastrointestinal hormones, including glucagon-like peptide (GLP)-1, peptide YY, oxyntomodulin, GLP-2, glucose-dependent insulinotropic polypeptide, ghrelin, and others, can play roles in energy homeostasis and could be involved in bariatric-surgery-related weight loss and weight loss maintenance. Vagal innervation may play a role. In addition, there may be other yet-uncharacterized factors that could participate. This review discusses the possible roles of these hormonal mechanisms in various types of bariatric surgery to help elucidate some of the potential mechanisms at play in short-term and long-term post-bariatric surgery weight loss. Understanding such mechanisms could lead to new and efficacious means to control or even reduce the epidemic of obesity.

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“…In this situation, postsurgical weight loss caused different fluctuations in ghrelin levels: either an increase 65,66 or a decrease in plasma ghrelin 67,68 or, in some cases, no changes. 69 This variability in circulating ghrelin levels after metabolic surgery attracted the interest of numerous research teams in attempting to elucidate the mechanisms of postoperative weight loss.…”

Section: Ghrelin and Weight Statusmentioning

confidence: 99%

Effects of ghrelin in energy balance and body weight homeostasis

Mihalache¹,

Gherasim²,

Niţă³

et al. 2016

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ghrelin is a gut peptide composed of 28 amino acids mostly secreted in the gastric fundus mucosa. It was isolated and described in 1999 by Kojima et al. and only three years later its specific receptor, ghsR1a, was also identified. ghrelin, the endogenous ligand for the gh secretagogue receptor, is the only peripheral orexigenic hormone that activates the receptors to be found especially in the appetite center (hypothalamus and pituitary gland). ghrelin is present in human plasma in two forms: an inactive form known as deacylated ghrelin, and an active form called acylated ghrelin synthesized under the action of ghrelin O-acyltransferase enzyme (gOAT). The literature even mentions an extremely complex ghrelin/gOAT/ghsR system involved in the regulation of human energy, metabolism and adaptation of energy homeostasis to environmental changes. In humans, there is a preprandial rise and a postprandial fall in plasma ghrelin levels, which strongly suggest that the peptide plays a physiological role in meal initiation and may be employed in determining the amount and quality of ingested food. Besides the stimulation of food intake, ghrelin determines a decrease in energy expenditure and promotes the storage of fatty acids in adipocytes. Thus, in the human body ghrelin induces a positive energy balance, an increased adiposity gain, as well as an increase in caloric storage, seen as an adaptive mechanism to caloric restriction conditions. In the current world context, when we are witnessing an increasing availability of food and a reduction of energy expenditure to a minimum level, these mechanisms have become pathogenic. As a consequence, the hypothesis that ghrelin is involved in the current obesity epidemic has been embraced by many scholars and researchers

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Ghrelin and Obestatin Levels in Severely Obese Women Before and After Weight Loss After Roux-en-Y Gastric Bypass Surgery

Cited by 62 publications

References 40 publications

Ghrelin in obesity and endocrine diseases

Ghrelin in obesity and endocrine diseases

Mechanisms Responsible for Excess Weight Loss after Bariatric Surgery

Effects of ghrelin in energy balance and body weight homeostasis

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