Getting insight into how iron(III) oleate precursors affect the features of magnetite nanoparticles

Nader, Karam; Castellanos-Rubio, Idoia; Orúe, I.; Iglesias-Rojas, Daniela; Barón, Ander; Lezama, Luís; Insausti, Maite

doi:10.1016/j.jssc.2022.123619

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…The coercive field values at 5 K were obtained by normalising these hysteresis cycles to the magnetisation obtained at room temperature ( Figure 2 b, Table 2 ). The value of 40 mT for sample Fe 3 O 4 _B is typical of ferrimagnetic NPs of Fe 3 O 4 with diameters near 20 nm [ 42 ]. In this case, the reduced remanence value (M r /M s ) is close to 0.5, which is the value predicted using the model of Stoner–Wohlfarth for uniaxial single domains with no magnetic interactions between the particles [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

Preparation of Selenium-Based Drug-Modified Polymeric Ligand-Functionalised Fe3O4 Nanoparticles as Multimodal Drug Carrier and Magnetic Hyperthermia Inductor

Galarreta-Rodriguez

Etxebeste-Mitxeltorena

Moreno

et al. 2023

Pharmaceuticals

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In recent years, much effort has been invested into developing multifunctional drug delivery systems to overcome the drawbacks of conventional carriers. Magnetic nanoparticles are not generally used as carriers but can be functionalised with several different biomolecules and their size can be tailored to present a hyperthermia response, allowing for the design of multifunctional systems which can be active in therapies. In this work, we have designed a drug carrier nanosystem based on Fe3O4 nanoparticles with large heating power and 4-amino-2-pentylselenoquinazoline as an attached drug that exhibits oxidative properties and high selectivity against a variety of cancer malignant cells. For this propose, two samples composed of homogeneous Fe3O4 nanoparticles (NPs) with different sizes, shapes, and magnetic properties have been synthesised and characterised. The surface modification of the prepared Fe3O4 nanoparticles has been developed using copolymers composed of poly(ethylene-alt-maleic anhydride), dodecylamine, polyethylene glycol and the drug 4-amino-2-pentylselenoquinazoline. The obtained nanosystems were properly characterised. Their in vitro efficacy in colon cancer cells and as magnetic hyperthermia inductors was analysed, thereby leaving the door open for their potential application as multimodal agents.

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Section: Resultsmentioning

confidence: 99%

Preparation of Selenium-Based Drug-Modified Polymeric Ligand-Functionalised Fe3O4 Nanoparticles as Multimodal Drug Carrier and Magnetic Hyperthermia Inductor

Galarreta-Rodriguez

Etxebeste-Mitxeltorena

Moreno

et al. 2023

Pharmaceuticals

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“…The XRD spectra of the Fenton catalyst can be observed in Figure 9, where it is possible to observe a peak characteristic of the crystalline planes (220), (311), (400), (422), ( 511) and (440), typical of magnetite in the sample Fe3O4 [50,51], indicating that the synthesis was made successfully. Figure 7 shows the number of electrons transferred in the reaction obtained w RRDE.…”

Section: X-ray Diffractionmentioning

confidence: 94%

Facile Synthesis of Carbon-Based Inks to Develop Metal-Free ORR Electrocatalysts for Electro-Fenton Removal of Amoxicillin

Valencia-Valero,

Fajardo-Puerto,

Elmouwahidi

et al. 2024

Gels

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The electro-Fenton process is based on the generation of hydroxyl radicals (OH•) from hydroxide peroxide (H2O2) generated in situ by an oxygen reduction reaction (ORR). Catalysts based on carbon gels have aroused the interest of researchers as ORR catalysts due to their textural, chemical and even electrical properties. In this work, we synthesized metal-free electrocatalysts based on carbon gels doped with graphene oxide, which were conformed to a working electrode. The catalysts were prepared from organic-gel-based inks using painted (brush) and screen-printed methods free of binders. These new methods of electrode preparation were compared with the conventional pasted method on graphite supports using a binder. All these materials were tested for the electro-Fenton degradation of amoxicillin using a homemade magnetite coated with carbon (Fe3O4/C) as a Fenton catalyst. All catalysts showed very good behavior, but the one prepared by ink painting (brush) was the best one. The degradation of amoxicillin was close to 90% under optimal conditions ([Fe3O4/C] = 100 mg L−1, −0.55 V) with the catalyst prepared using the painted method with a brush, which had 14.59 mA cm−2 as JK and a H2O2 electrogeneration close to 100% at the optimal voltage. These results show that carbon-gel-based electrocatalysts are not only very good at this type of application but can be adhered to graphite free of binders, thus enhancing all their catalytic properties.

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“…Two different Fe3O4 nanoparticles (NPs) were synthesized by thermal decomposition of an iron(III) oleate (FeOl) precursor which was previously prepared from iron(III) chloride and sodium oleate mixed in a mixture of solvents (hexane, ethanol and distilled water). The synthesis process of both the FeOl precursor and the Fe3O4 NPs was formerly analyzed and optimized throughout different works [34][35][36]. For this work two different samples composed of NPs of similar average dimension (≈ 20 nm) but different morphology (cuboctahedral and octahedral) have been prepared (samples Fe3O4_A and Fe3O4_B).…”

Section: Methodsmentioning

confidence: 99%

NANO.PTML Model for read-across prediction of nanosystems in neurosciences. Computational model and experimental case of study

He,

Nader,

Abarrategi

et al. 2024

Preprint

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Neurodegenerative diseases involve progressive neuronal death. Traditional treatments often struggle due to solubility, bioavailability, and crossing the Blood-Brain Barrier (BBB). Nanoparticles (NPs) in biomedical field are garnering growing attention as neurodegenerative disease drugs (NDDs) carrier to the central nervous system. Here, a specific IFPTML technique was used, which combined Information Fusion (IF) + Perturbation Theory (PT) + Machine Learning (ML) to select the most promising NDDS and NP candidates and to address the few data in the literature. IF-process was carried out between 4403 NDDS assays and 260 cytotoxicity NP assays conducting a dataset of 500000 cases. The optimal IFPTML identified was the DT algorithm, demonstrating satisfactory performance with specificity values of 96.4% and 96.2%, and sensitivity values of 79.3% and 75.7% in the training (375k/75%) and validation (125k/25%) set. Moreover, the DT model obtained AUROC scores of 0.97 and 0.96 in the training and validation series, highlighting its effectiveness in classification tasks. On the other hand, two samples of NPs (Fe3O4_A and Fe3O4_B) were synthesized and structurally characterized by different methods. Additionally, in order to make the as-synthesized hydrophobic NPs (Fe3O4_A and Fe3O4_B) soluble in water the amphiphilic CTAB (hexadecyltrimethylammonium bromide) molecule was employed. Therefore, to conduct a study with a wider range of NP system variants, an experimental illustrative simulation experiment was performed using the IFPTML-DT model. For this, a set of 500000 prediction dataset was created involving n(NP cores)=5 vs. n(cell lines) =53 vs. n(NP shapes) =5 vs. n(NP coats) =16 vs. n(drugs) =123. The outcome of this experiment highlighted certain NANO.PTML systems as promising candidates for further investigation. Specifically, the experiment revealed that the cell line Lycopersicon esculentum showed promise for ecotoxicity studies across various coating systems. In contrast, Danio rerio cell lines (embryos, juveniles, and adults) showed lower predictive values, suggesting less favorable candidates. MacGowan volume was notably relevant for CTAB, PS, and PEG as coating agents, excluding PVA. The NANO.PTML approach holds potential to accelerate experimental investigations and offer initial insights into various NP and NDDS compounds, serving as an efficient alternative to time-consuming trial-and-error procedures.

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Getting insight into how iron(III) oleate precursors affect the features of magnetite nanoparticles

Cited by 6 publications

References 33 publications

Preparation of Selenium-Based Drug-Modified Polymeric Ligand-Functionalised Fe3O4 Nanoparticles as Multimodal Drug Carrier and Magnetic Hyperthermia Inductor

Preparation of Selenium-Based Drug-Modified Polymeric Ligand-Functionalised Fe3O4 Nanoparticles as Multimodal Drug Carrier and Magnetic Hyperthermia Inductor

Facile Synthesis of Carbon-Based Inks to Develop Metal-Free ORR Electrocatalysts for Electro-Fenton Removal of Amoxicillin

NANO.PTML Model for read-across prediction of nanosystems in neurosciences. Computational model and experimental case of study

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